INT38738

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Context Info
Confidence 0.68
First Reported 1986
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.45

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cytosol (RIPK2) signal transduction (RIPK2) intracellular (RIPK2)
cytoplasm (RIPK2) signal transducer activity (RIPK2)
RIPK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 4 100.00 Very High Very High Very High
substance P 1 96.64 Very High Very High Very High
cINOD 1 73.12 Quite High
Disease Link Frequency Relevance Heat
Injury 1 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Higher doses of indomethacin (10(-5)-10(-6) M) potentiated histamine (10(-4) M) and db-cAMP (10(-4) M)-stimulated pepsinogen secretion without affecting acetylcholine (10(-6) M) and CCK-8-stimulated pepsinogen secretion or cell vitality.
Localization (secretion) of CCK
1) Confidence 0.68 Published 1996 Journal Rev Esp Enferm Dig Section Abstract Doc Link 9004795 Disease Relevance 0.07 Pain Relevance 0.07
Among the various biologically active peptides tested, the purified enzyme releases efficiently the N-terminal dipeptide moiety from enkephalins, Trp-Met-Asp-Phe-NH2 (CCK4), and Gly-Trp-Met-Asp-Phe-NH2 (CCK5).
Localization (releases) of CCK5 associated with enkephalin
2) Confidence 0.00 Published 1986 Journal Biochemistry Section Abstract Doc Link 3814577 Disease Relevance 0 Pain Relevance 0.38

General Comments

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