INT38872

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Context Info
Confidence 0.42
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.51
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Dsp) protein binding, bridging (Dsp)
Anatomy Link Frequency
heart 2
cortex 1
hippocampus 1
Dsp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 12 99.08 Very High Very High Very High
antagonist 2 98.94 Very High Very High Very High
Pain 6 98.42 Very High Very High Very High
cocaine 9 97.92 Very High Very High Very High
Desipramine 1 97.48 Very High Very High Very High
Morphine 4 97.16 Very High Very High Very High
fluoxetine 2 97.08 Very High Very High Very High
depression 2 86.52 High High
tail-flick 1 86.40 High High
Potency 1 85.44 High High
Disease Link Frequency Relevance Heat
Neuropathy 13 100.00 Very High Very High Very High
Infarction 8 99.20 Very High Very High Very High
Stress 4 98.96 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 96.92 Very High Very High Very High
Mycobacterial Infection 4 95.88 Very High Very High Very High
Infection 1 95.76 Very High Very High Very High
Dysesthesia 1 90.20 High High
Hypoxia 2 90.12 High High
Pain 2 89.56 High High
Depression 2 86.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since infarction-associated disorders of myocardial structure and function in non-ischemic regions of the heart are due to the emotional-painful stress that accompanies the infarction, it can be assumed that the protective effect of DSP and cDSP consists in limiting the stress-induced response.
Negative_regulation (effect) of DSP in heart associated with stress, pain and infarction
1) Confidence 0.42 Published 1985 Journal Kardiologiia Section Abstract Doc Link 3839544 Disease Relevance 0.73 Pain Relevance 0.14
Since infarction-associated disorders of myocardial structure and function in non-ischemic regions of the heart are due to the emotional-painful stress that accompanies the infarction, it can be assumed that the protective effect of DSP and cDSP consists in limiting the stress-induced response.
Negative_regulation (effect) of cDSP in heart associated with stress, pain and infarction
2) Confidence 0.42 Published 1985 Journal Kardiologiia Section Abstract Doc Link 3839544 Disease Relevance 0.73 Pain Relevance 0.14
In cortex and hippocampus 5-HT levels were slightly, but significantly decreased after DSP-4.
Negative_regulation (decreased) of DSP-4 in cortex associated with hippocampus
3) Confidence 0.37 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 7505893 Disease Relevance 0 Pain Relevance 0.58
Further research on the optimal care of these patients and multi-disciplinary approaches to DSP prevention are needed.


Negative_regulation (prevention) of DSP
4) Confidence 0.37 Published 2005 Journal Eur. J. Intern. Med. Section Body Doc Link 16314241 Disease Relevance 0 Pain Relevance 0
However, there was a non-significant reduction in DSP calls with paracetamol in the first recall period alone (P = 0.057).
Negative_regulation (reduction) of DSP
5) Confidence 0.37 Published 2002 Journal Med. J. Aust. Section Body Doc Link 11913916 Disease Relevance 0.07 Pain Relevance 0
Our findings raise the possibility that the incidence of DSP may be reduced with avoidance of stavudine-containing regimens in older subjects, especially with a history of prior TB infection.
Negative_regulation (reduced) of DSP associated with mycobacterial infection, neuropathy and infection
6) Confidence 0.32 Published 2010 Journal Muscle Nerve Section Abstract Doc Link 20229576 Disease Relevance 1.78 Pain Relevance 0.13
The effect of DSP4 was prevented by pretreatment with the selective inhibitor of uptake of NA, desipramine.
Negative_regulation (prevented) of DSP4 associated with desipramine
7) Confidence 0.25 Published 1984 Journal Neuropharmacology Section Abstract Doc Link 6521853 Disease Relevance 0.08 Pain Relevance 0.61
Bilateral microinjection of the selective noradrenergic neurotoxin, DSP4 (50 micrograms), or equimolar concentration (500 pmol) of the alpha 1-adrenoceptor antagonist, prazosin, or alpha 2-adrenoceptor antagonist, yohimbine, into the mPFC significantly blunted the decrease in delta component (prazosin) or both delta and theta components (DSP4 or yohimbine) of EEG activity by the lower dose of cocaine.
Negative_regulation (decrease) of DSP4 associated with antagonist and cocaine
8) Confidence 0.17 Published 1995 Journal Synapse Section Abstract Doc Link 8584976 Disease Relevance 0 Pain Relevance 0.55
In cortex and hippocampus 5-HT levels were slightly, but significantly decreased after DSP-4.
Negative_regulation (decreased) of DSP-4 in hippocampus associated with hippocampus
9) Confidence 0.13 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 7505893 Disease Relevance 0 Pain Relevance 0.58
CONCLUSION: Parity, spastic floor syndrome and psychoneurosis seem to be the risk factors predisposing to failure of DSP, which may be followed by severe complications and early recurrence of symptoms requiring reoperation.


Negative_regulation (failure) of DSP
10) Confidence 0.10 Published 2003 Journal Tech Coloproctol Section Body Doc Link 14628157 Disease Relevance 0.12 Pain Relevance 0

General Comments

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