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Context Info
Confidence 0.32
First Reported 1985
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.90
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CELA3B) extracellular region (CELA3B)
Anatomy Link Frequency
pancreas 1
CELA3B (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 7 77.28 Quite High
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 16 100.00 Very High Very High Very High
Pancreatitis 17 99.00 Very High Very High Very High
Exocrine Pancreatic Insufficiency 2 98.20 Very High Very High Very High
Cancer 35 97.24 Very High Very High Very High
Steatorrhea 1 68.72 Quite High
Metastasis 1 67.68 Quite High
Diarrhoea 2 67.52 Quite High
Adenocarcinoma 51 61.80 Quite High
Disorder Of Lipid Metabolism 1 54.56 Quite High
Malignant Neoplastic Disease 3 23.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fecal elastase-1 estimation is an alternative fecal enzyme test for the detection of exocrine pancreatic insufficiency, which, in contrast to chymotrypsin estimation, uses monoclonal antibodies against human pancreatic elastase and is thus unaffected by simultaneous pancreatic enzyme replacement therapy.
Neg (unaffected) Regulation (unaffected) of pancreatic elastase associated with exocrine pancreatic insufficiency
1) Confidence 0.32 Published 2004 Journal Curr Gastroenterol Rep Section Abstract Doc Link 15191690 Disease Relevance 0.44 Pain Relevance 0.07
Changes in serum levels of pancreatic isoamylase, lipase, trypsin, and elastase 1 after endoscopic retrograde pancreatography.
Regulation (Changes) of elastase 1
2) Confidence 0.26 Published 1985 Journal Hepatogastroenterology Section Title Doc Link 3847383 Disease Relevance 0.08 Pain Relevance 0.08
In addition, five down-regulated proteins identified in pancreatic cancer juice (carboxypeptidase A2, chymotrypsinogen B, elastase-3A, elastase-3B and trypsin-1) was also down-regulated in pancreatic cancer tissues compared with pancreatitis and normal pancreas tissues as described by Shen et al. [9].
Regulation (regulated) of elastase-3B in pancreas associated with pancreatitis and pancreatic cancer
3) Confidence 0.11 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.38 Pain Relevance 0

General Comments

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