INT38963

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Context Info
Confidence 0.41
First Reported 1981
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 1.91
Pain Relevance 4.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bar 2
brain 1
ergot 1
Lsd (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 51 99.98 Very High Very High Very High
Opioid 9 99.76 Very High Very High Very High
MU agonist 3 99.66 Very High Very High Very High
Nicotine 13 99.46 Very High Very High Very High
Pyramidal cell 8 98.90 Very High Very High Very High
fluoxetine 2 97.76 Very High Very High Very High
headache 2 97.64 Very High Very High Very High
Migraine 6 96.32 Very High Very High Very High
agonist 69 95.96 Very High Very High Very High
anesthesia 1 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cortical Blindness 2 100.00 Very High Very High Very High
Headache 6 97.64 Very High Very High Very High
Migraine Without Aura 1 94.60 High High
Disease 2 93.88 High High
Vomiting 1 92.68 High High
Psychosis 1 91.48 High High
Galactorrhea 2 91.28 High High
Acromegaly 2 90.36 High High
Blindness 3 89.72 High High
Cluster Headache 2 88.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This review will discuss the various chemicals and receptors that are important with pyramidal neurons including opioids, nicotine, scopolamine, psilocybin, LSD, mescaline, ergot alkaloids, salvinorin A, ergine and other compounds that interact with opioid, nicotinic, muscarinic and serotonergic receptors.
LSD Binding (interact) of in ergot associated with nicotine, pyramidal cell and opioid
1) Confidence 0.41 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19799545 Disease Relevance 0.31 Pain Relevance 1.28
[Recurrent cortical blindness after LSD-intake].
LSD Binding (blindness) of associated with cortical blindness
2) Confidence 0.32 Published 2009 Journal Fortschr Neurol Psychiatr Section Title Doc Link 19221973 Disease Relevance 1.01 Pain Relevance 0.44
Behavioral effects of xylamine-induced depletions of brain norepinephrine: interaction with LSD.
LSD Binding (interaction) of in brain
3) Confidence 0.31 Published 1985 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 3877938 Disease Relevance 0 Pain Relevance 0.39
LSD binds to D1, D2, D3, D4, and D5 receptors (Nichols et al. 2002) and has been reported to act as a partial agonist at D1 receptors (Watts et al. 1995).
LSD Binding (binds) of associated with agonist
4) Confidence 0.15 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2797624 Disease Relevance 0 Pain Relevance 0.51
Lisuride and LSD bind non-selectively to a variety of serotonergic, dopaminergic, and adrenergic receptors (Leysen 1989; Piercey et al. 1996; Egan et al. 1998; Marona-Lewicka et al. 2002; Millan et al. 2002; Nichols et al. 2002).
LSD Binding (bind) of
5) Confidence 0.15 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2797624 Disease Relevance 0.59 Pain Relevance 0.27
For example, LSD, which is widely abused, does not appear to be addictive.
LSD Binding (example) of
6) Confidence 0.07 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1635740 Disease Relevance 0 Pain Relevance 0.48
The selected opioid metenkephalin synthetic peptide analogs Lilly (LY) 127623 and FK 33-824 were tested for behavioral dose effects and potential interaction with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) in adult male Holtzman rats trained on a positive reinforcement fixed-ratio 4 (FR-4) behavioral bar pressing schedule, i.e., a reward of 0.01 ml sugar-sweetened evaporated milk was earned on every fourth bar press.
LSD Binding (interaction) of in bar associated with opioid
7) Confidence 0.04 Published 1983 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6413999 Disease Relevance 0 Pain Relevance 0.17
Several opioid agonists and antagonists interact with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) in adult male Holtzman rats trained on a positive reinforcement, fixed ratio 4 (FR4) behavioral schedule, i.e., a reward of 0.01 ml sugar-sweetened milk was earned on every fourth bar press.
LSD Binding (interact) of in bar associated with mu agonist and antagonist
8) Confidence 0.03 Published 1981 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6798611 Disease Relevance 0 Pain Relevance 0.58

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