INT39047

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Context Info
Confidence 0.78
First Reported 1981
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 34
Total Number 35
Disease Relevance 17.48
Pain Relevance 6.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PGF) signal transduction (PGF) extracellular region (PGF)
cell-cell signaling (PGF)
Anatomy Link Frequency
placenta 3
endometrium 2
joint 2
blood 2
macrophages 1
PGF (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 8 99.44 Very High Very High Very High
Inflammation 102 99.08 Very High Very High Very High
Pain 13 98.60 Very High Very High Very High
COX2 175 98.58 Very High Very High Very High
Dismenorea 6 98.48 Very High Very High Very High
Paracetamol 4 96.72 Very High Very High Very High
diclofenac 102 90.08 High High
cINOD 21 89.32 High High
cytokine 132 86.88 High High
aspirin 21 85.72 High High
Disease Link Frequency Relevance Heat
Cancer 479 100.00 Very High Very High Very High
Breast Cancer 43 99.98 Very High Very High Very High
Pre-eclampsia 450 99.52 Very High Very High Very High
INFLAMMATION 111 99.08 Very High Very High Very High
Gallbladder Disease 2 98.84 Very High Very High Very High
Pain 11 98.60 Very High Very High Very High
Dysmenorrhea 4 98.48 Very High Very High Very High
Cholecystitis 10 98.28 Very High Very High Very High
Infection 16 97.04 Very High Very High Very High
Malignant Neoplastic Disease 18 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that the human endometrium is a rich source of PGF and PGE and that the production of PGF is regulated by gonadal steroids.
Gene_expression (production) of PGF in endometrium
1) Confidence 0.78 Published 1982 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 7065034 Disease Relevance 0 Pain Relevance 0.09
However, strong evidence suggests that promotion of VSM growth is mediated by local production of platelet growth factor (PGF) and ANG-II (Williams 1998).
Gene_expression (production) of PGF in platelet
2) Confidence 0.75 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 0.80 Pain Relevance 0.21
In animal models, expression of both PGD and PGF synthases declines during acute inflammation, only to rise again during the resolution phase, suggesting their possible role in resolving inflammation.
Gene_expression (expression) of PGF associated with inflammation
3) Confidence 0.75 Published 2009 Journal J. Investig. Med. Section Abstract Doc Link 19240648 Disease Relevance 0.87 Pain Relevance 0.43
NS-398 dose-dependently decreased the levels of COX-2 mRNA, COX-2 protein, nuclear NF-kappaB protein and production of PGF(1alpha) and increased the cytoplasmic IkappaB protein.
Gene_expression (levels) of PGF
4) Confidence 0.75 Published 2009 Journal Cancer Invest. Section Abstract Doc Link 19160097 Disease Relevance 0.82 Pain Relevance 0.13
The inconsistent and low levels of expression of the intron 1-retaining COX-1 variants suggest that these variants are not likely responsible for the inhibition of PGF(2alpha) production and skeletal muscle protein synthesis after resistance exercise by ibuprofen and acetaminophen.
Gene_expression (production) of PGF in skeletal muscle associated with paracetamol
5) Confidence 0.75 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17322116 Disease Relevance 0 Pain Relevance 0.22
We also examined pepsinogen C (PgC) and F (PgF) mRNA expression by RT-PCR.
Spec (examined) Gene_expression (expression) of PgF
6) Confidence 0.65 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 12843612 Disease Relevance 0.08 Pain Relevance 0.12
In animal models, expression of both PGD and PGF synthases declines during acute inflammation, only to rise again during the resolution phase, suggesting their possible role in resolving inflammation.
Gene_expression (synthases) of PGF associated with inflammation
7) Confidence 0.65 Published 2009 Journal J. Investig. Med. Section Abstract Doc Link 19240648 Disease Relevance 0.92 Pain Relevance 0.45
NS-398 dose-dependently decreased the levels of COX-2 mRNA, COX-2 protein, nuclear NF-kappaB protein and production of PGF(1alpha) and increased the cytoplasmic IkappaB protein.
Gene_expression (production) of PGF
8) Confidence 0.58 Published 2009 Journal Cancer Invest. Section Abstract Doc Link 19160097 Disease Relevance 0.80 Pain Relevance 0.12
In rationally designed cell systems ideal for determining direct effects of the inhibitors on mPGES-1 function, but not its expression, PF-9184 inhibited PGE(2) synthesis (IC(50) in the range of 0.5-5 microM in serum-free cell and human whole blood cultures, respectively) while sparing the synthesis of 6-keto-PGF(1alpha) (PGF(1alpha)) and PGF(2alpha).
Gene_expression (synthesis) of PGF in blood
9) Confidence 0.58 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20067770 Disease Relevance 0.45 Pain Relevance 0.33
In contrast, as expected, the selective COX-2 inhibitor, SC-236, inhibited PGE(2), PGF(1alpha) and PGF(2alpha) synthesis.
Gene_expression (synthesis) of PGF associated with cox-2 inhibitor
10) Confidence 0.58 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20067770 Disease Relevance 0.37 Pain Relevance 0.28
In 60 patients (median age 61 [33-72] years, male/female: 50/10) plasma levels of endotoxin, endotoxin neutralizing capacity (ENC), leukotriene-C4 (LTC4), 6-ketoprostaglandin-F-1alpha (PGF), thromboxane-B2 (TxB2), interleukin-6 (IL-6), and C-reactive protein (CRP) were measured before, during, and after cardiac surgery.
Gene_expression (levels) of PGF in plasma
11) Confidence 0.58 Published 2001 Journal Angiology Section Abstract Doc Link 11515987 Disease Relevance 0.34 Pain Relevance 0.13
In rationally designed cell systems ideal for determining direct effects of the inhibitors on mPGES-1 function, but not its expression, PF-9184 inhibited PGE(2) synthesis (IC(50) in the range of 0.5-5 microM in serum-free cell and human whole blood cultures, respectively) while sparing the synthesis of 6-keto-PGF(1alpha) (PGF(1alpha)) and PGF(2alpha).
Gene_expression (synthesis) of PGF in blood
12) Confidence 0.58 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20067770 Disease Relevance 0.45 Pain Relevance 0.33
In contrast, as expected, the selective COX-2 inhibitor, SC-236, inhibited PGE(2), PGF(1alpha) and PGF(2alpha) synthesis.
Gene_expression (synthesis) of PGF associated with cox-2 inhibitor
13) Confidence 0.58 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20067770 Disease Relevance 0.36 Pain Relevance 0.28
We further suggest that the stimulation of PGF production by oxytocin is mediated by oxytocin receptors, probably in the decidua.
Gene_expression (production) of PGF in decidua
14) Confidence 0.54 Published 1981 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 6274193 Disease Relevance 0.17 Pain Relevance 0.17
These findings indicate that the human endometrium is a rich source of PGF and PGE and that the production of PGF is regulated by gonadal steroids.
Gene_expression (source) of PGF in endometrium
15) Confidence 0.53 Published 1982 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 7065034 Disease Relevance 0 Pain Relevance 0.09
In a randomized double-blind trial, the effect of ibuprofen on the pain produced by gallbladder disease and on gallbladder mucosa and muscle wall tissue PGE and PGF production was evaluated to determine if the pain of cholecystitis and prostaglandin formation were altered by administration of a prostaglandin synthetase inhibitor.
Gene_expression (production) of PGF in muscle associated with pain, gallbladder disease and cholecystitis
16) Confidence 0.49 Published 1985 Journal Dig. Dis. Sci. Section Abstract Doc Link 3896701 Disease Relevance 0.39 Pain Relevance 0.20
Gallbladder mucosa and muscle tissue produced nanogram per milligram protein amounts of PGE and PGF.
Gene_expression (produced) of PGF in muscle tissue
17) Confidence 0.49 Published 1985 Journal Dig. Dis. Sci. Section Abstract Doc Link 3896701 Disease Relevance 0.76 Pain Relevance 0.38
We suggest that oxytocin stimulates PGF production in the pregnant uterus when it is appropriately sensitized to oxytocin, causing a potentiation of the oxytocin-induced contractions which is necessary for the contractions to become efficient in dilating the cervix.
Gene_expression (production) of PGF in cervix
18) Confidence 0.48 Published 1981 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 6274193 Disease Relevance 0.19 Pain Relevance 0.19
In a multivariable model, elevated levels of TnT (HR, 1.83; 95% CI, 1.05-3.86; P =.03), sCD40L (HR, 2.65; 95% CI, 1.41-4.99; P =.002), and PlGF (HR, 3.03; 95% CI, 1.54-5.95; P<.001) were independent predictors, while elevated hsCRP level was not (HR, 0.98; 95% CI, 0.53-1.98; P =.94).
Gene_expression (levels) of PlGF
19) Confidence 0.39 Published 2004 Journal JAMA Section Body Doc Link 14747500 Disease Relevance 0.06 Pain Relevance 0
Flt-1 can be activated by VEGF and placental growth factor (PlGF), which are highly expressed in the placenta.
Gene_expression (expressed) of PlGF in placenta
20) Confidence 0.39 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2496902 Disease Relevance 0.51 Pain Relevance 0.04

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