INT39249

Context Info Confidence 0.41 First Reported 1985 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 5 Total Number 6 Disease Relevance 2.72 Pain Relevance 3.18

lyase activity (NPL) carbohydrate metabolic process (NPL) cytoplasm (NPL)

Anatomy Link Frequency plasma 1 NPL (Homo sapiens)

Pain Link Frequency Relevance Heat Nerve growth factor 98 100.00 narcan 47 100.00 qutenza 94 99.72 Inflammation 4 89.48 antagonist 6 89.12 Opioid 18 88.64 amygdala 55 82.08 opiate 1 69.40 medulla 2 63.76 Endogenous opioid 1 57.96

Disease Link Frequency Relevance Heat Rhinitis 4 99.62 Frailty 10 99.24 Cough 48 98.42 Asthma 14 94.88 Hypersensitivity 16 94.44 INFLAMMATION 2 89.48 Congenital Anomalies 2 87.40 Muscle Weakness 1 86.24 Hypopituitarism 1 85.08 Mucositis 2 81.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The plasma glucagon response to exercise at 70% VO2max was not altered by NAL administration but was significantly elevated in the 90%-NAL vs. the 90%-SAL trial.

Positive_regulation (elevated) of NAL in plasma

1) Confidence 0.41 Published 1994 Journal J. Appl. Physiol. Section Abstract Doc Link 7928870 Disease Relevance 0 Pain Relevance 0.27

Alprazolam (APZ) attenuates the ACTH release in response to Nal in normal individuals, probably by inhibiting CRH release.

Spec (probably) Positive_regulation (attenuates) of Nal associated with narcan

2) Confidence 0.31 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9663654 Disease Relevance 1.10 Pain Relevance 0.37

After TP, however, despite unchanged basal LH levels (mean +/- S.E.M.: 27.0 +/- 3.4 vs 21.2 +/- 3.21 microU/ml), LH significantly increased in response to NAL.

Positive_regulation (increased) of NAL associated with narcan

3) Confidence 0.24 Published 1985 Journal Psychoneuroendocrinology Section Abstract Doc Link 3933025 Disease Relevance 0.15 Pain Relevance 0.51

The main finding of this study is that patients with SHR do have enhanced cough sensitivity to inhaled capsaicin, which correlates to a small but significant increase in NGF in NAL after capsaicin provocation.

Positive_regulation (increase) of NAL associated with nerve growth factor, qutenza and cough

4) Confidence 0.06 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257644 Disease Relevance 0.37 Pain Relevance 0.89

In patients with allergic rhinitis, levels of NGF in NAL were increased after allergen provocation compared with control subjects (Sanico et al. 2000).

Positive_regulation (increased) of NAL associated with rhinitis and nerve growth factor

5) Confidence 0.06 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257644 Disease Relevance 0.83 Pain Relevance 0.74

These observations rule out the possibility that the effects of NAL on ERK activity and extinction were the result of an acute effect on freezing.

Positive_regulation (effects) of NAL associated with narcan

6) Confidence 0.03 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.27 Pain Relevance 0.41

General Comments

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