INT39271

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Context Info
Confidence 0.48
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.97
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
leg 2
Hdlcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 8 99.72 Very High Very High Very High
Restless leg syndrome 2 81.20 Quite High
behavioral therapy 7 10.68 Low Low
Analgesic 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 208 100.00 Very High Very High Very High
Hyperlipidemia 8 100.00 Very High Very High Very High
Pain 7 99.72 Very High Very High Very High
Congenital Anomalies 4 97.48 Very High Very High Very High
Increased Venous Pressure Under Development 47 94.16 High High
Cardiovascular Disease 5 88.64 High High
Metabolic Syndrome 28 81.56 Quite High
Peripheral Arterial Disease 2 75.00 Quite High
Hyperphagia 4 64.16 Quite High
Diabetes Mellitus 49 62.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mean HDL-cholesterol levels were lower for those with GXT-induced leg pain in all three sex-hormone usage groups (42.0 vs 46.9, p less than .001; 53.9 vs 59.4, p less than .001; 65.3 vs 67.2, p = NS) and mean low-density lipoprotein cholesterol levels were higher in those with leg pain on GXT in two of three groups (146.4 vs 146.2, p = NS; 155.7 vs 144.6, p less than .01; 144.4 vs 133.5, p less than .05).
Positive_regulation (lower) of Gene_expression (levels) of HDL-cholesterol in leg associated with pain and disorder of lipid metabolism
1) Confidence 0.48 Published 1986 Journal Circulation Section Abstract Doc Link 3940676 Disease Relevance 1.12 Pain Relevance 0.55
Since HDL-cholesterol is an important cardiovascular risk factor, addressing both hypercholesterolemia and low HDL-cholesterol is a rational clinical strategy for patients with these lipid abnormalities.
Positive_regulation (Since) of Gene_expression (addressing) of HDL-cholesterol associated with congenital anomalies, hyperlipidemia and disorder of lipid metabolism
2) Confidence 0.31 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.15 Pain Relevance 0
Since HDL-cholesterol is an important cardiovascular risk factor, addressing both hypercholesterolemia and low HDL-cholesterol is a rational clinical strategy for patients with these lipid abnormalities.
Positive_regulation (Since) of Gene_expression (addressing) of HDL-cholesterol associated with congenital anomalies, hyperlipidemia and disorder of lipid metabolism
3) Confidence 0.31 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.16 Pain Relevance 0
Serum low-density lipoprotein (LDL)-cholesterol level was calculated from serum TC, HDL-cholesterol and TG levels (Friedewald et al., 1972).


Positive_regulation (calculated) of Gene_expression (levels) of HDL-cholesterol associated with disorder of lipid metabolism
4) Confidence 0.13 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2809238 Disease Relevance 0.54 Pain Relevance 0

General Comments

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