INT39367

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Context Info
Confidence 0.42
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.53
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna2) plasma membrane (Chrna2)
Anatomy Link Frequency
neuronal 1
myotube 1
Chrna2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 3 100.00 Very High Very High Very High
Nicotine 8 97.80 Very High Very High Very High
narcan 16 97.32 Very High Very High Very High
Clonidine 4 97.00 Very High Very High Very High
Morphine 8 96.76 Very High Very High Very High
addiction 6 88.28 High High
withdrawal 2 87.00 High High
antagonist 3 78.32 Quite High
lidocaine 1 76.56 Quite High
Rostral ventrolateral medulla 1 72.92 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 2 87.36 High High
Pheochromocytoma 1 81.20 Quite High
Pressure Volume 2 Under Development 1 73.84 Quite High
Disorders Of The Lacrimal System 1 72.24 Quite High
Overactive Bladder 1 70.96 Quite High
Cancer 2 62.68 Quite High
Paralysis 1 33.04 Quite Low
Unconsciousness 1 28.16 Quite Low
Pain 1 26.08 Quite Low
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged exposure to carbachol disrupts the acetylcholine receptor (AChR) clusters of cultured rat myotubes without causing myotube loss.
Negative_regulation (disrupts) of AChR in myotube
1) Confidence 0.42 Published 1986 Journal J. Neurosci. Section Abstract Doc Link 3958790 Disease Relevance 0 Pain Relevance 0.19
Methyllycaconitine (1, 2 and 5 mg/kg), an alpha7 nicotinic acetylcholine receptor subtype inhibitor, significantly and dose dependently inhibited the attenuating effect of nicotine on naloxone-induced place aversion.
Negative_regulation (inhibitor) of nicotinic acetylcholine receptor associated with nicotine and narcan
2) Confidence 0.38 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16098507 Disease Relevance 0.09 Pain Relevance 0.90
In contrast, dihydroxy-beta-erithroidine (1, 2 and 5 mg/kg), an alpha4beta2 nicotinic acetylcholine receptor subtype inhibitor, did not have any effect on the attenuating effect of nicotine on naloxone-induced place aversion.
Negative_regulation (inhibitor) of nicotinic acetylcholine receptor associated with nicotine and narcan
3) Confidence 0.38 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16098507 Disease Relevance 0.08 Pain Relevance 0.93
Clonidine and cirazoline displaced the ion channel ligand [3H]-phencyclidine from nicotinic acetylcholine receptors, suggesting that these drugs act by direct blockade of the intrinsic ion channel of the nicotinic acetylcholine receptor. 6.
Negative_regulation (blockade) of nicotinic acetylcholine receptor associated with clonidine
4) Confidence 0.35 Published 1996 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 8911748 Disease Relevance 0.16 Pain Relevance 0.44
When the cells were treated with the 1 mM choline and 15 nM nanoparticle complex, we confirmed that the CA secretion evoked by ACh and stimulation of the selective neuronal-type AChR agonist, DMPP, were reduced by about 75% after 60 min.8 When ACh was readministered after about 1.5 hr, we confirmed that reversal was achieved (Figure 3).
Negative_regulation (reduced) of AChR in neuronal associated with agonist
5) Confidence 0.27 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2875724 Disease Relevance 0.21 Pain Relevance 0.11

General Comments

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