INT39417

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Context Info
Confidence 0.76
First Reported 1985
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 65
Total Number 70
Disease Relevance 32.10
Pain Relevance 7.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 5
mast cell 3
Th1 cells 2
B cells 2
marginal zone 1
Fcer2a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 584 100.00 Very High Very High Very High
Inflammation 731 99.64 Very High Very High Very High
Thermal hyperalgesia 2 99.04 Very High Very High Very High
anesthesia 43 98.00 Very High Very High Very High
Inflammatory response 110 97.08 Very High Very High Very High
Glutamate receptor 2 95.56 Very High Very High Very High
endometriosis 15 95.40 Very High Very High Very High
diclofenac 12 94.36 High High
pain pelvic 4 93.60 High High
Freund adjuvant 60 93.12 High High
Disease Link Frequency Relevance Heat
Immunization 262 99.88 Very High Very High Very High
Rhinitis 70 99.88 Very High Very High Very High
Hyperplasia 40 99.70 Very High Very High Very High
INFLAMMATION 834 99.64 Very High Very High Very High
Sprains And Strains 261 99.64 Very High Very High Very High
Hypersensitivity 1224 99.48 Very High Very High Very High
Eczema 359 99.48 Very High Very High Very High
Mantle-cell Lymphoma 116 99.48 Very High Very High Very High
Asthma 461 99.44 Very High Very High Very High
Pressure And Volume Under Development 7 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activated B cells have recently been shown to produce soluble CD23 from their membranes.
Gene_expression (produce) of CD23 in B cells
1) Confidence 0.76 Published 1995 Journal Hum. Reprod. Section Abstract Doc Link 7650148 Disease Relevance 0.47 Pain Relevance 0.33
Furthermore, our data showed that neonatal capsaicin treatment did not interfere with either IgG1 or IgE production.
Gene_expression (production) of IgE
2) Confidence 0.56 Published 2001 Journal Neuroimmunomodulation Section Body Doc Link 11549890 Disease Relevance 0 Pain Relevance 0
As we have previously noted [19], the pattern of CD21 and CD23 surface expression on MHV68 infected cells is somewhat distinct from that observed in naïve mice.
Gene_expression (expression) of CD23
3) Confidence 0.31 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.24 Pain Relevance 0
Indeed, it has been shown that both CD21 and CD23 expression can be modulated by EBV, KSHV and MHV68 [26],[27] (C.M.
Gene_expression (expression) of CD23 associated with epstein-barr virus
4) Confidence 0.31 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.24 Pain Relevance 0
, which is responsible for regulating tryptophan metabolism, FCER2 (Fc fragment of IgE receptor), MAST2 (member of IL-4 signalling, a microtubule associated serine/threonine kinase), GRIA4 (glutamate receptor), and LTA (member of TNF super family).
Gene_expression (fragment) of FCER2 associated with glutamate receptor
5) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.13 Pain Relevance 0.05
Genes correlated with NF-kappaB include INDO (a indoleamine-pyrrole 2,3 dioxygenase that represents a target for IFN-?)
Gene_expression (include) of FCER2
6) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.14 Pain Relevance 0.05
A murine model of immediate allergic reaction was used to evaluate warifteine treatment in the IgE production, leukocyte activation, thermal hyperalgesia, mast cell degranulation and scratching behavior.
Gene_expression (production) of IgE in mast cell associated with thermal hyperalgesia and hypersensitivity
7) Confidence 0.22 Published 2008 Journal Int. Immunopharmacol. Section Abstract Doc Link 18328442 Disease Relevance 0.67 Pain Relevance 0.10
An alternative hypothesis is that the route of administration, dose of allergen inhaled (or ingested), and genetic predisposition are the principal factors that affect allergen recognition and development of allergen-specific TH2 responses that ultimately lead to IgE production.
Gene_expression (production) of IgE associated with genetic predisposition to disease
8) Confidence 0.19 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 0.41 Pain Relevance 0.04
Exposure of adult mice to LPS suppressed IgE production, airway inflammation, and development of bronchial hyperresponsiveness (Gerhold et al. 2003).
Gene_expression (production) of IgE associated with inflammation
9) Confidence 0.19 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 0.40 Pain Relevance 0.05
Briefly, 96-well plates (Nunc Maxisorp, Denmark) were coated overnight at 4° C with anti-mouse IgE (R35-72; BD PharMingen, San Diego, USA).
Gene_expression (coated) of IgE
10) Confidence 0.19 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0 Pain Relevance 0.06
In contrast, serum IgE levels at day 14, after a single injection, were not significantly elevated (p = 0.438) compared to naïve mice.
Gene_expression (levels) of IgE
11) Confidence 0.19 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0 Pain Relevance 0
The immunophenotype of marginal lymphomas is distinct from other small lymphocytic lymphomas: the antigen profile for the marginal zone lymphomas include CD19, CD20, CD22 positive and CD5, CD10, CD23, and CD11C negative.
Neg (negative) Gene_expression (negative) of CD23 in marginal zone associated with b-cell chronic lymphocytic leukemia and lymphatic system cancer
12) Confidence 0.18 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 1.14 Pain Relevance 0
Why do allergens induce IgE responses?
Gene_expression (responses) of IgE
13) Confidence 0.17 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 0.29 Pain Relevance 0.03
The group 2 mite allergens elicit IgE responses in 90% of mite allergic patients (Smith et al. 2001).
Gene_expression (responses) of IgE associated with hypersensitivity
14) Confidence 0.17 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 0.47 Pain Relevance 0.04
The most important allergen associated with IgE responses, Bla g 2, belongs to a subgroup of the aspartic proteinase family of enzymes that is enzymatically inactive (Arruda et al. 2001; Pomes et al. 2002).
Gene_expression (responses) of IgE
15) Confidence 0.17 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 0.29 Pain Relevance 0.03
Flow cytometric analysis of CD23 expression in CD5-positive B cells is a widely applied method in the differential diagnosis of CLL and MCL.
Gene_expression (expression) of CD23 in B cells associated with mantle-cell lymphoma
16) Confidence 0.16 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.87 Pain Relevance 0.07
The respiratory allergen trimellitic anhydride (TMA) has been shown to induce IgE production and immediate ear swelling in mice sensitized to it.
Gene_expression (production) of IgE in respiratory associated with pressure and volume under development
17) Confidence 0.14 Published 1997 Journal J Appl Toxicol Section Abstract Doc Link 9418942 Disease Relevance 0.33 Pain Relevance 0.17
Serum antibodies of the IgG and IgE and some of the IgA isotype were found, particularly in SC-sensitized animals.
Gene_expression (found) of IgE
18) Confidence 0.14 Published 1985 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 3968326 Disease Relevance 0.19 Pain Relevance 0.04
According to the most accepted criteria, the leukemic cell population is CD19/CD5/CD23 triple positive in CLL but CD23-negative in MCL.
Gene_expression (positive) of CD23 associated with mantle-cell lymphoma
19) Confidence 0.14 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.93 Pain Relevance 0.06
According to the most accepted criteria, the leukemic cell population is CD19/CD5/CD23 triple positive in CLL but CD23-negative in MCL.
Gene_expression (positive) of CD23 associated with mantle-cell lymphoma
20) Confidence 0.14 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.93 Pain Relevance 0.07

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