INT39469

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Context Info
Confidence 0.41
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 13.33
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Alb) enzyme binding (Alb) DNA binding (Alb)
protein complex (Alb) response to stress (Alb) cytoplasm (Alb)
Anatomy Link Frequency
plasma 2
sputum 1
liver 1
brain 1
pericytes 1
Alb (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 21 99.12 Very High Very High Very High
anesthesia 7 98.92 Very High Very High Very High
Paracetamol 17 96.96 Very High Very High Very High
carbamazepine 16 92.88 High High
ischemia 4 86.80 High High
Kinase C 37 86.44 High High
Bioavailability 11 84.84 Quite High
isoflurane 5 84.76 Quite High
Inflammation 200 75.88 Quite High
Bile 8 75.00 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Disease 216 99.52 Very High Very High Very High
Overdose 4 99.44 Very High Very High Very High
Targeted Disruption 23 99.08 Very High Very High Very High
Weight Loss 14 98.98 Very High Very High Very High
Asthma 96 98.80 Very High Very High Very High
Proteinuria 24 98.70 Very High Very High Very High
Diarrhoea 10 98.18 Very High Very High Very High
Cirrhosis 69 98.08 Very High Very High Very High
Infection 53 97.96 Very High Very High Very High
Hepatotoxicity 11 97.94 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Second, impaired circulation within the congested liver, as manifested by reduced 125I-albumin entry into the liver when 125I-albumin was injected after congestion had developed, probably aggravates the initial injury.
Negative_regulation (reduced) of albumin in liver associated with injury
1) Confidence 0.41 Published 1985 Journal Hepatology Section Abstract Doc Link 3979955 Disease Relevance 0.50 Pain Relevance 0.46
To display total protein content in the CSF, high-abundance proteins, such as IgG and albumin, were not depleted.
Neg (not) Negative_regulation (depleted) of albumin
2) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2730746 Disease Relevance 0.61 Pain Relevance 0.26
In a multicenter randomized study, it was also reported that long-term oral supplementation with a BCAA mixture improved the serum albumin level as well as cellular energy metabolism in cirrhotic patients [102].
Negative_regulation (improved) of serum albumin associated with cirrhosis
3) Confidence 0.27 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3017957 Disease Relevance 0.87 Pain Relevance 0
Albumin clearance rates were decreased significantly (2 weeks postinjection) only in the RA patients.
Negative_regulation (decreased) of Albumin
4) Confidence 0.26 Published 1994 Journal Arthritis Rheum. Section Body Doc Link 8024612 Disease Relevance 0.29 Pain Relevance 0
The intensity of in vivo staining for formaldehyde-treated serum albumin, which is a specific ligand for SECs, was reduced from 2 to 12 hours.
Negative_regulation (reduced) of albumin in SECs
5) Confidence 0.24 Published 2003 Journal Microcirculation Section Body Doc Link 14557822 Disease Relevance 0 Pain Relevance 0
In mice treated 9x with the PCN, the protection against a subsequent primary influenza virus infection was characterized by a significantly greater reduction in viral burdens by day 7 post-infection (Figure 3A), and by the absence of any weight loss (Figure 3B), and lung damage, as indicated by the decreased levels of albumin (Figure 3C) and lactate dehydrogenase (LDH) (Figure 3D) recovered from the broncho-alveolar lavage fluid (BALF) [11], [12].
Negative_regulation (decreased) of albumin in lung associated with weight loss, influenza virus infection and infection
6) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.52 Pain Relevance 0
NIRF imaging was performed 2 h after injection of Cy5.5-albumin and the brain was then removed from the skull under deep anesthesia and used for ex vivo NIRF imaging [Fig. 4
Negative_regulation (removed) of albumin in brain associated with anesthesia and imagery
7) Confidence 0.18 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3005168 Disease Relevance 0.34 Pain Relevance 0.40
Blood levels of albumin and triglyceride were also decreased indicating that c-Met knockout mice could not regenerate liver mass and function efficiently (Figure S2C and D).


Negative_regulation (decreased) of albumin in Blood associated with targeted disruption
8) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.42 Pain Relevance 0.17
Study-related toxicities were hypotension (6 patients); greater than 10% weight gain (6 patients); peripheral edema (9 patients); fever (4 patients); confusion (3 patients); diarrhea (3 patients); proteinuria, as identified by dipstick (3 patients), greater than 0.6 mg/dl decrease in serum albumin (11 patients); greater than 25% decrease in oncotic pressure (10 patients), and a decrease in ionized calcium (8 patients).
Negative_regulation (decrease) of albumin associated with pressure and volume under development, diarrhoea, pressure volume 2 under development, proteinuria, fever, weight gain and confusion
9) Confidence 0.15 Published 1995 Journal Am. J. Clin. Oncol. Section Abstract Doc Link 7625372 Disease Relevance 1.47 Pain Relevance 0.07
Three months of treatment with the combination of aliskiren/losartan (150/100 mg/d), reduced the urinary albumin creatinine ratio by 11% compared with losartan alone.
Negative_regulation (reduced) of albumin
10) Confidence 0.13 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.62 Pain Relevance 0.04
Free binding sites were blocked in 2% and 5% (w/v) bovine serum albumin (for nitrated proteins and LO, resp.) in 20?
Negative_regulation (blocked) of serum albumin
11) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2852597 Disease Relevance 0 Pain Relevance 0.07
The total protein was decreased at 58g/l (60-80g/l) and the albumin markedly decreased at 14g/l (29-42g/l).
Negative_regulation (decreased) of albumin
12) Confidence 0.07 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.88 Pain Relevance 0.07
In 1996, Kozyr modified the previous procedure by using saturated ammonium sulfate for total IgG precipitation and Cibracon Blue 3GA for fast albumin removal, followed by ion exchange chromatography on DEAE-Sepharose FF, protein G-affinity chromatography for specific binding of the total IgG fraction, and selection of DNA–binding fraction on Sephacryl.
Negative_regulation (removal) of albumin
13) Confidence 0.06 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0 Pain Relevance 0
DR complications result from functional and morphological alterations of retinal capillaries, increased permeability to albumin and macromolecules, vascular dysfunction, loss of pericytes and basement membrane thickening.
Negative_regulation (loss) of albumin in pericytes associated with diabetic retinopathy
14) Confidence 0.04 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.61 Pain Relevance 0.13
Coadministration of 5beta-scymnol (70 mg/kg) and NAC (250 mg/kg) also reduced serum enzyme levels and histopathological effects; however, a similar level of hepatoprotection was conferred by 5beta-scymnol treatment alone.
Negative_regulation (reduced) of serum enzyme
15) Confidence 0.03 Published 1996 Journal Fundam Appl Toxicol Section Abstract Doc Link 8812214 Disease Relevance 0.42 Pain Relevance 0.29
N-Acetylcysteine (NAC) is protective against APAP-induced hepatotoxicity at 250 and 500 mg/kg (ip) when administered up to 3 hr after APAP overdose, as shown by a significant reduction in serum enzyme activity.
Negative_regulation (reduction) of serum enzyme associated with hepatotoxicity and overdose
16) Confidence 0.03 Published 1996 Journal Fundam Appl Toxicol Section Abstract Doc Link 8812214 Disease Relevance 0.44 Pain Relevance 0.31
However, such treatment did reduce levels of albumin and eosinophil cationic protein in sputum samples obtained from patients with COPD (Grootendorst, Gauw, Benschop et al 2003).


Negative_regulation (reduce) of albumin in sputum associated with pulmonary disease
17) Confidence 0.02 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 1.20 Pain Relevance 0.09
In patients with COPD, small but significant reductions in sputum levels of albumin and eosinophil cationic protein were observed.
Negative_regulation (reductions) of albumin in eosinophil associated with pulmonary disease
18) Confidence 0.02 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 1.17 Pain Relevance 0.07
While plasma albumin levels decline with age, alpha 1 glycoprotein either remains unchanged or may increase.
Negative_regulation (decline) of albumin in plasma
19) Confidence 0.02 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2861844 Disease Relevance 0.35 Pain Relevance 0.09
Competition for protein binding may result in fewer available binding sites for albumin, and transient increases in free drug concentrations may occur, influencing the concentration and clearance of concomitantly administered medications.34,35 TPM binds to AAG, globulins, lipoproteins, and erythrocytes, only binding to plasma proteins to a small degree (13%–17%).36,37 As a result of these binding and distribution properties, TPM free (unbound) serum concentrations may not be as affected as other medications by age-related reductions of plasma albumin levels, or by significant protein binding displacement interactions when used in combination with lipophilic and protein-bound AEDs.38

Metabolism

Negative_regulation (reductions) of albumin in plasma
20) Confidence 0.02 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2861844 Disease Relevance 0 Pain Relevance 0.06

General Comments

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