INT3959

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Context Info
Confidence 0.27
First Reported 1976
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.48
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lipg) extracellular space (Lipg) extracellular region (Lipg)
lipid metabolic process (Lipg)
Anatomy Link Frequency
soleus 1
gut 1
Lipg (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 1 100.00 Very High Very High Very High
Inflammation 6 88.64 High High
imagery 17 78.88 Quite High
fibrosis 14 68.72 Quite High
Chronic pancreatitis 96 5.36 Low Low
Bile 7 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 47 100.00 Very High Very High Very High
INFLAMMATION 6 100.00 Very High Very High Very High
Hyperlipidemia 10 96.78 Very High Very High Very High
Pancreatitis 123 93.60 High High
Targeted Disruption 21 91.44 High High
Death 2 85.52 High High
Hypertrophy 18 85.04 High High
Hyperplasia 9 80.72 Quite High
Fatty Liver 2 69.36 Quite High
Fibrosis 4 68.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of anti-inflammatory drugs on lipase in vitro.
Regulation (Effect) of lipase associated with inflammation and cinod
1) Confidence 0.27 Published 1976 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Title Doc Link 935643 Disease Relevance 0.10 Pain Relevance 0.10
Consistent with the Kit-induced hepatic phenotype, interference with lipase function induces type I hyperlipoproteinemia in human (OMIN238600) and more severe hyperchylomicronemia affecting post-natal viability in Lpl mutant mice [37] or in Combined Lipase deficiency (Cld), which alters both Lpl and Hepatic lipase (Lipc) activities [38-40].
Regulation (alters) of lipase associated with hyperlipidemia
2) Confidence 0.15 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.22 Pain Relevance 0
Effects of total chikusetsusaponins and various purified chikusetsusaponins on pancreatic lipase activity in vitro
Regulation (Effects) of lipase
3) Confidence 0.14 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1097713 Disease Relevance 0.18 Pain Relevance 0
However when anti-myostatin antibodies were administered to two month old severe combined immunodeficient mice or myostatin was postnatally inactivated using a Cre-LoxP system in four month old mice there was no change in MHC profile of the soleus and EDL [29], [32].
Neg (no) Regulation (change) of EDL in soleus
4) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.79 Pain Relevance 0
Angiopoietin-like 4 (ANGPTL4) is a circulating lipoprotein lipase (LPL) inhibitor that controls triglyceride deposition into adipocytes and has been reported to be regulated by gut microbes.


Regulation (regulated) of lipase in gut associated with obesity
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948012 Disease Relevance 0.18 Pain Relevance 0.04
The animals showed slightly elevated serum levels of lipase without any significant histological alteration, suggesting a subtle acinar damage.
Neg (without) Regulation (alteration) of lipase
6) Confidence 0.02 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 1.00 Pain Relevance 0.15

General Comments

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