INT3969

From wiki-pain
Revision as of 22:10, 23 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1976
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 27
Total Number 36
Disease Relevance 7.52
Pain Relevance 12.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sds) lyase activity (Sds) cellular_component (Sds)
cellular amino acid metabolic process (Sds) cytoplasm (Sds)
Anatomy Link Frequency
gastrocnemius 3
SDH 2
visceral 1
ciliary 1
central canal 1
Sds (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 225 100.00 Very High Very High Very High
spinal dorsal horn 24 100.00 Very High Very High Very High
substance P 24 100.00 Very High Very High Very High
Spinal cord 62 99.84 Very High Very High Very High
Morphine 4 99.84 Very High Very High Very High
Paracetamol 64 99.82 Very High Very High Very High
ASIC 5 99.74 Very High Very High Very High
IPN 1 99.68 Very High Very High Very High
nud 20 99.44 Very High Very High Very High
cerebral cortex 1 99.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
Autoimmune Disease 14 99.76 Very High Very High Very High
Neuropathic Pain 50 99.72 Very High Very High Very High
Inflammatory Pain 2 99.68 Very High Very High Very High
Dyspepsia 21 99.44 Very High Very High Very High
Pain 23 98.98 Very High Very High Very High
Stress 28 98.86 Very High Very High Very High
Hepatotoxicity 19 98.72 Very High Very High Very High
Nervous System Injury 184 98.44 Very High Very High Very High
Recurrence 6 97.28 Very High Very High Very High
Paralysis 7 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although exercise-trained medial gastrocnemius showed significant adaptations (increased mean SDH activity of type I and increased proportion and total SDH activity of type I and combined I + IIa fibers), SDH activity of innervating motoneurons (identified by retrograde tracing using fast blue) was unchanged.
Positive_regulation (increased) of SDH in gastrocnemius
1) Confidence 0.69 Published 1994 Journal J. Appl. Physiol. Section Abstract Doc Link 7868444 Disease Relevance 0.17 Pain Relevance 0.22
However, extract-pretreated rats attenuated in a dose-dependent manner, CCl(4) and acetaminophen-induced increases in the activities of ALT, AST, ALP, LDH and SDH in the blood serum.
Positive_regulation (increases) of SDH in blood associated with paracetamol
2) Confidence 0.67 Published 2006 Journal Phytother Res Section Abstract Doc Link 16941609 Disease Relevance 0.07 Pain Relevance 0.40
Some neurons in the parietal area of the cerebral cortex and endotheliocytes in blood vessels showed increases in NO synthesis and in the activity of energy metabolism enzymes (SDH, LDH).
Positive_regulation (increases) of SDH in cerebral cortex associated with cerebral cortex
3) Confidence 0.67 Published 2004 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 15526421 Disease Relevance 0.17 Pain Relevance 0.23
The contents of SP in SDH was elevated dramatically at the peak of immune responses.
Positive_regulation (elevated) of SDH in SDH associated with spinal dorsal horn and substance p
4) Confidence 0.67 Published 1996 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Abstract Doc Link 9388989 Disease Relevance 0.81 Pain Relevance 1.30
Isolated mitochondria of the 6-week ethanol group were approximately 50% more susceptible to NAPQI (25-165 micromol/L) induced SDH inactivation.
Positive_regulation (induced) of SDH
5) Confidence 0.67 Published 2002 Journal Hepatology Section Abstract Doc Link 12143040 Disease Relevance 0.45 Pain Relevance 0.55
We also studied whether ciliary neurotrophic factor (CNTF) is involved in regulating the postsynaptic accumulation of SDH.
Spec (whether) Positive_regulation (accumulation) of SDH in ciliary
6) Confidence 0.64 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8769787 Disease Relevance 0 Pain Relevance 0.28
Although exercise-trained medial gastrocnemius showed significant adaptations (increased mean SDH activity of type I and increased proportion and total SDH activity of type I and combined I + IIa fibers), SDH activity of innervating motoneurons (identified by retrograde tracing using fast blue) was unchanged.
Positive_regulation (increased) of SDH in gastrocnemius
7) Confidence 0.50 Published 1994 Journal J. Appl. Physiol. Section Abstract Doc Link 7868444 Disease Relevance 0.17 Pain Relevance 0.22
Although exercise-trained medial gastrocnemius showed significant adaptations (increased mean SDH activity of type I and increased proportion and total SDH activity of type I and combined I + IIa fibers), SDH activity of innervating motoneurons (identified by retrograde tracing using fast blue) was unchanged.
Positive_regulation (increased) of SDH in gastrocnemius
8) Confidence 0.47 Published 1994 Journal J. Appl. Physiol. Section Abstract Doc Link 7868444 Disease Relevance 0.17 Pain Relevance 0.22
The increase of SP contents in SDH may inhibit the immune system via unknown pathway and ease clinical severity of the autoimmune disease, where SP might act as neurotransmitter in the immunoregulation of the negative feedback.
Positive_regulation (increase) of SDH in immune system associated with neurotransmitter, autoimmune disease, spinal dorsal horn and substance p
9) Confidence 0.45 Published 1996 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Abstract Doc Link 9388989 Disease Relevance 0.79 Pain Relevance 1.28
We investigated the regulatory effects of neural activation and trophic factors on the selective accumulation of succinate dehydrogenase (SDH; EC 1.3.99.1) activity at the endplate, as well as within subsarcolemmal and intermyofibrillar regions of rat soleus muscle fibers.
Spec (investigated) Positive_regulation (accumulation) of SDH in neural
10) Confidence 0.43 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8769787 Disease Relevance 0 Pain Relevance 0.23
Previous pharmacological and behavioral studies suggest that peripheral acid-sensing ion channels (ASICs) contribute to pain sensation, and the expression of ASIC subunits is elevated in the rat spinal dorsal horn (SDH) in an inflammatory pain model.
Positive_regulation (elevated) of SDH in SDH associated with pain, ipn, spinal dorsal horn and asic
11) Confidence 0.38 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17928456 Disease Relevance 0.50 Pain Relevance 0.88
Both doses of acetaminophen produced significant elevations of serum alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH) activities in 4-month-old rats.
Positive_regulation (elevations) of SDH associated with paracetamol
12) Confidence 0.34 Published 1988 Journal Drug Chem Toxicol Section Abstract Doc Link 3181038 Disease Relevance 0.24 Pain Relevance 0.42
Testicular SDH activity was increased by morphine at 1 hr followed by a decrease at 4 hr.
Positive_regulation (increased) of SDH associated with morphine
13) Confidence 0.34 Published 1996 Journal Indian J. Exp. Biol. Section Abstract Doc Link 8698427 Disease Relevance 0 Pain Relevance 0.62
Clear elevation of ALT/SDH activities was detected in the co-treated group.
Positive_regulation (elevation) of SDH
14) Confidence 0.33 Published 2000 Journal Xenobiotica Section Abstract Doc Link 11055270 Disease Relevance 0.23 Pain Relevance 0.83
Our results showed that the activity of SDH was significantly increased by taurine administration in adult rats, and the activities of SDH and LDH were obviously elevated in aged rats.
Positive_regulation (increased) of SDH
15) Confidence 0.32 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0.06 Pain Relevance 0
On the other hand, dose-dependent elevations in serum enzyme glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT) and sorbitol dehydrogenase (SDH) activities and hepatic triglyceride (TG) levels were observed following the administration of single doses of 0.5 and lg/kg acetaminophen.
Positive_regulation (elevations) of SDH associated with paracetamol
16) Confidence 0.24 Published 1976 Journal Toxicology Section Abstract Doc Link 941168 Disease Relevance 0.15 Pain Relevance 0.53
Our results showed an increase in SDH activity by 48?
Positive_regulation (increase) of SDH
17) Confidence 0.23 Published 2010 Journal International Journal of Biomaterials Section Body Doc Link PMC2927743 Disease Relevance 0.16 Pain Relevance 0
hrs, CPC-2 suppressed SDH activity by >55% relative to the Teflon Control, and then showed some tendency toward an increase in SDH activity with time (48?
Positive_regulation (increase) of SDH
18) Confidence 0.23 Published 2010 Journal International Journal of Biomaterials Section Body Doc Link PMC2927743 Disease Relevance 0.21 Pain Relevance 0.03
Although oral administration of 400 mg/kg acetaminophen (APAP) or 1.8-3.4 g/kg sucrose had no effect on serum levels of alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH), their co-administration resulted in 20-fold increases in ALT/SDH activities.
Positive_regulation (increases) of SDH associated with paracetamol
19) Confidence 0.22 Published 2000 Journal Xenobiotica Section Abstract Doc Link 11055270 Disease Relevance 0.17 Pain Relevance 0.59
Sucrose-associated increase in serum ALT/SDH activities was selective with APAP and not detected with carbon tetrachloride (160 mg/kg, i.p.), D-galactosamine (400 mg/kg, i.p.) or alpha-naphthyl isothiocyanate (100 mg/kg, p.o.). 3.
Positive_regulation (increase) of SDH associated with paracetamol
20) Confidence 0.22 Published 2000 Journal Xenobiotica Section Abstract Doc Link 11055270 Disease Relevance 0.17 Pain Relevance 0.66

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox