INT39711

From wiki-pain
Revision as of 13:24, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 1981
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 4.29
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (FOXC1) nucleus (FOXC1) DNA binding (FOXC1)
transcription factor binding (FOXC1) cytoplasm (FOXC1)
Anatomy Link Frequency
colon 2
FOXC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 15 97.20 Very High Very High Very High
Inflammation 238 90.40 High High
Pain 2 89.12 High High
Angina 1 87.04 High High
cytokine 280 85.08 High High
cerebral cortex 10 75.72 Quite High
midbrain 3 65.16 Quite High
Thalamus 7 64.64 Quite High
headache 1 63.24 Quite High
Crohn's disease 49 53.44 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 224 100.00 Very High Very High Very High
Precursor Cell Lymphoblastic Leukemia-lymphoma 1 99.12 Very High Very High Very High
Hodgkin's Disease 1 98.32 Very High Very High Very High
Recurrence 14 95.48 Very High Very High Very High
Syndrome 5 93.20 High High
Fever 1 90.80 High High
INFLAMMATION 245 90.40 High High
Myalgia 1 90.24 High High
Pain 1 89.12 High High
Angina 1 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Responders in contrast to most nonresponders were characterized by a higher intracellular level of ara-C and its metabolites following the first 24-h infusion of the drug.
Negative_regulation (level) of ara
1) Confidence 0.41 Published 1985 Journal Cancer Res. Section Abstract Doc Link 4027995 Disease Relevance 0.37 Pain Relevance 0.06
Four patients with non-Hodgkin lymphoma and two with acute lymphocytic leukemia (ages 4 and 4 months to 16 years 6 months) exhibited a unique reaction to intravenously administered cytosine arabinoside (Ara-C) given alone as a part of the previously reported LSA2-L2 treatment protocol.
Negative_regulation (exhibited) of Ara associated with precursor cell lymphoblastic leukemia-lymphoma and hodgkin's disease
2) Confidence 0.41 Published 1981 Journal Med. Pediatr. Oncol. Section Abstract Doc Link 6941069 Disease Relevance 1.03 Pain Relevance 0.18
These results will be useful as a guide to future investigations of CNS function in the absence of dietary DHA and ARA.



Negative_regulation (absence) of ARA
3) Confidence 0.25 Published 2005 Journal BMC Med Section Abstract Doc Link PMC1184078 Disease Relevance 0 Pain Relevance 0.10
Thus, decreasing cellular ARA levels seems to be a crucial step.
Negative_regulation (decreasing) of ARA
4) Confidence 0.08 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.61 Pain Relevance 0.12
Since OA is already the most abundant fatty acid present in our diet [9] and in the colon mucosa [4], decreasing mucosal ARA levels may be easier by increasing fish oil intake than by increasing OA intake.
Negative_regulation (decreasing) of ARA in colon
5) Confidence 0.08 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.55 Pain Relevance 0.14
The results of this latter condition showed that decreasing ARA levels in the mucosa seems to be more important than increasing EPA levels.
Negative_regulation (decreasing) of ARA
6) Confidence 0.06 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.20 Pain Relevance 0.07
Our data showed that replacing ARA for EPA or OA decreased ICAM-1 expression and NF-?
Negative_regulation (replacing) of ARA
7) Confidence 0.06 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.25 Pain Relevance 0.13
Cells cultured with ARA showed in particular an increase in the proportion of long chain n-6 PUFAs (mainly ARA) and a decrease in n-9 MUFAs (mainly OA) as compared with cells cultured with only OA.
Negative_regulation (decrease) of ARA
8) Confidence 0.06 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.06 Pain Relevance 0.09
Indeed, by increasing their intake of fish oil, ARA in the colon mucosa of IBD patients was replaced by EPA and DHA [12], which was associated with significantly reduced corticosteroid requirements [12] and lower relapse rates [13].
Negative_regulation (replaced) of ARA in colon associated with inflammatory bowel disease, corticosteroid and recurrence
9) Confidence 0.06 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.90 Pain Relevance 0.14
However, this array was intended to generate hypotheses about differences in immune modulating effect of ARA versus EPA based on the protein expression profiles.
Negative_regulation (effect) of ARA
10) Confidence 0.06 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.32 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox