INT39777

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Context Info
Confidence 0.62
First Reported 1985
Last Reported 2010
Negated 20
Speculated 13
Reported most in Abstract
Documents 90
Total Number 103
Disease Relevance 31.52
Pain Relevance 68.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
spinal cord 6
spinal 5
neurons 4
plasma 2
nucleus 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 1856 100.00 Very High Very High Very High
agonist 192 100.00 Very High Very High Very High
nMDA receptor 175 100.00 Very High Very High Very High
antagonist 156 100.00 Very High Very High Very High
tolerance 39 100.00 Very High Very High Very High
adenocard 11 100.00 Very High Very High Very High
Clonidine 4 100.00 Very High Very High Very High
amygdala 378 99.98 Very High Very High Very High
Spinal cord 349 99.98 Very High Very High Very High
addiction 24 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 175 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 99.98 Very High Very High Very High
Diabetic Neuropathy 102 99.88 Very High Very High Very High
Diabetes Mellitus 291 99.84 Very High Very High Very High
INFLAMMATION 81 99.76 Very High Very High Very High
Nervous System Injury 41 99.64 Very High Very High Very High
Cv Unclassified Under Development 6 99.64 Very High Very High Very High
Ganglion Cysts 179 99.60 Very High Very High Very High
Hyperalgesia 168 99.44 Very High Very High Very High
Nociception 228 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic administration of morphine and butorphanol produced no change in the membrane PKC activity.
Neg (no) Regulation (change) of PKC associated with kinase c, butorphanol and morphine
1) Confidence 0.62 Published 1994 Journal Brain Res. Section Abstract Doc Link 7953672 Disease Relevance 0 Pain Relevance 2.04
The aim of this study was to determine whether chronic opioid treatment could influence the protein kinase C (PKC) activity in the rat brain.
Regulation (influence) of PKC in brain associated with kinase c and opioid
2) Confidence 0.62 Published 1994 Journal Brain Res. Section Abstract Doc Link 7953672 Disease Relevance 0 Pain Relevance 1.54
On the other hand, repeated U-50,488 treatment had no effect on PKC activity in cytosol and membrane fractions under the calcium-chelating conditions.
Neg (no) Regulation (effect) of PKC associated with kinase c
3) Confidence 0.60 Published 1994 Journal Brain Res. Section Abstract Doc Link 7895076 Disease Relevance 0 Pain Relevance 0.79
To determine whether protein kinase C (PKC) mediates release of peptides from sensory neurons, we examined the effects of altering PKC activity on resting and evoked release of substance P (SP) and calcitonin gene-related peptide (CGRP).
Spec (examined) Regulation (effects) of PKC in sensory neurons associated with kinase c, calcitonin gene-related peptide and substance p
4) Confidence 0.60 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8667028 Disease Relevance 0 Pain Relevance 0.56
Controlling NMDA receptor function and, thus, excitatory transmitter release via modulation of PKC suggests a novel potential target to contrast glutamate excitotoxicity in this motor nucleus.
Regulation (modulation) of PKC in nucleus associated with glutamate, kinase c and nmda receptor
5) Confidence 0.60 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18445055 Disease Relevance 0 Pain Relevance 0.81
The time-course effectiveness of the siRNA treatment in down-regulating PKC?
Regulation (regulating) of PKC associated with kinase c
6) Confidence 0.60 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.13
The significance of these results is that in the amygdala PKA and ERK, but not PKC, modulate information processing and behavior through separate (not serially arranged) signaling pathways.
Neg (not) Regulation (modulate) of PKC in amygdala associated with amygdala
7) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.55 Pain Relevance 0.85
Consistent with behavioral changes, CCI rats examined 3 or 10 days after sciatic nerve ligation displayed a three-dimensional pattern of increased membrane-bound PKC in the lumbar spinal cord (L1-L5) strikingly different from that of sham-operated rats: in the dorsoventral dimension, reliable increases in membrane-bound PKC occurred mainly within spinal cord laminae I-IV and V-VI in CCI rats; in the ipsilateral-contralateral dimension, changes in membrane-bound PKC were seen on both sides of the spinal cord in CCI rats with reliably higher levels of membrane-bound PKC on the side ipsilateral than on the side contralateral to sciatic nerve ligation; in the rostrocaudal dimension, increases in membrane-bound PKC in the spinal cord dorsal horns of CCI rats extended from spinal segments L2-L5. 4.
Regulation (changes) of PKC in spinal cord associated with kinase c, nervous system injury, sciatic nerve and spinal cord
8) Confidence 0.45 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8410149 Disease Relevance 1.16 Pain Relevance 1.41
In the present experiments, we examined (1) the cellular distribution of a PKC isoform (PKC gamma) in the spinal cord dorsal horn of rats associated with morphine tolerance by utilizing an immunocytochemical method and (2) the effects of the N-methyl-D-aspartate receptor antagonist MK-801 on tolerance-associated PKC gamma changes.
Regulation (effects) of PKC gamma in spinal cord dorsal horn associated with kinase c, antagonist, nmda receptor, tolerance, dorsal horn, morphine and spinal cord
9) Confidence 0.45 Published 1995 Journal Brain Res. Section Abstract Doc Link 7552251 Disease Relevance 0 Pain Relevance 1.94
PKC activity and protein expression did not change when assessed 1 h after bolus i.t. morphine in naive rats.
Neg (not) Regulation (change) of PKC associated with kinase c and morphine
10) Confidence 0.45 Published 2000 Journal Pain Section Abstract Doc Link 10781912 Disease Relevance 0 Pain Relevance 1.84
These data suggest that in acutely dissociated rat dorsal root ganglion neurons, endogenous PKC is required for maintenance of calcium current, may play a role in regulation of neuronal calcium channels, and could be involved in tolerance and/or cross-talk inhibition of opioid responsiveness.
Regulation (regulation) of PKC in neuronal associated with ganglion cysts, calcium channel, tolerance, root ganglion neuron and opioid
11) Confidence 0.45 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087019 Disease Relevance 0.17 Pain Relevance 0.81
These results, showing that D-fenfluramine altered PKC activity similar to D-amphetamine, suggest that the topographic homology between DAT and SERT may extend to their effects on PKC activity.
Regulation (effects) of PKC associated with kinase c
12) Confidence 0.45 Published 2003 Journal Synapse Section Abstract Doc Link 14515339 Disease Relevance 0 Pain Relevance 0.68
Similar effects on PKC activity have been observed with DAT inhibitors.
Regulation (effects) of PKC associated with kinase c
13) Confidence 0.45 Published 2003 Journal Synapse Section Abstract Doc Link 14515339 Disease Relevance 0 Pain Relevance 0.79
These results indicate a role for G(alphas), the PLC-PKC pathway, and L-type calcium channels in intrathecal morphine-induced hyperalgesia in rats.
Regulation (role) of PLC-PKC associated with hyperalgesia, kinase c, calcium channel, morphine and intrathecal
14) Confidence 0.45 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 17893922 Disease Relevance 0.85 Pain Relevance 2.23
These results indicate a limited role for intracellular calcium stores and phorbol ester/DAG-sensitive PKC isoforms in NA-induced contraction of epididymal rat vas deferens in calcium-free medium.
Regulation (role) of PKC in vas deferens associated with kinase c and noradrenaline
15) Confidence 0.45 Published 1999 Journal Life Sci. Section Abstract Doc Link 10416820 Disease Relevance 0 Pain Relevance 0.78
Its dependence on NMDA receptor activation implicates isoforms of PKC that are sensitive to intracellular calcium, such as PKC gamma.
Regulation (sensitive) of PKC associated with addiction, kinase c and nmda receptor
16) Confidence 0.45 Published 1997 Journal Brain Res. Section Abstract Doc Link 9098555 Disease Relevance 0.43 Pain Relevance 0.87
Relaxation responses to the alpha 2-adrenoceptor agonist clonidine, the endothelium-dependent vasodilator adenosine 5'-diphosphate, and the PKC inhibitor staurosporine were reduced, but the relaxation to the endothelium-independent cyclic GMP-mediated vasodilator sodium nitroprusside was preserved.
Regulation (responses) of PKC in endothelium associated with kinase c, adenocard, agonist and clonidine
17) Confidence 0.44 Published 1997 Journal J. Surg. Res. Section Abstract Doc Link 9202648 Disease Relevance 0.40 Pain Relevance 0.51
In this study, we examined the roles of spinal protein kinase C (PKC) and protein kinase A (PKA) in the BV-induced different types of pain and hypersensitivity in conscious rats.
Spec (examined) Regulation (roles) of PKC in spinal associated with pain, kinase c and hypersensitivity
18) Confidence 0.44 Published 2003 Journal Neurosignals Section Abstract Doc Link 14739559 Disease Relevance 1.22 Pain Relevance 0.56
Effects of down-regulating PKC?
Regulation (regulating) of PKC associated with kinase c
19) Confidence 0.44 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.15
(C-1) Disappearance of inhibitory response of duodenal motilities, (C-2): no effect on excitatory response.
Neg (no) Regulation (effect) of C-1
20) Confidence 0.44 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529392 Disease Relevance 0.36 Pain Relevance 0.32

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