INT39788

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Context Info
Confidence 0.17
First Reported 1985
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.01
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
body 1
Scort1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 13 99.38 Very High Very High Very High
Nicotine 13 99.12 Very High Very High Very High
electroacupuncture 91 98.76 Very High Very High Very High
tolerance 10 98.70 Very High Very High Very High
narcan 3 98.60 Very High Very High Very High
Hyperalgesia 14 94.88 High High
analgesia 9 94.12 High High
Analgesic 1 89.52 High High
antagonist 4 88.64 High High
withdrawal 3 88.56 High High
Disease Link Frequency Relevance Heat
Weight Loss 1 99.90 Very High Very High Very High
Body Weight 1 99.80 Very High Very High Very High
Pressure And Volume Under Development 18 96.72 Very High Very High Very High
Hyperalgesia 16 94.88 High High
INFLAMMATION 26 87.76 High High
Stress 8 75.00 Quite High
Disease 4 51.08 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of naloxone after 1-6 days treatment with morphine elicited body weight loss and increase in plasma corticosterone (Pcs), degrees of which were dependent on the dose of naloxone or the period of morphine treatment.
Positive_regulation (increase) of plasma corticosterone in body associated with weight loss, body weight, narcan and morphine
1) Confidence 0.17 Published 1985 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 4040881 Disease Relevance 0.20 Pain Relevance 1.96
EA significantly increased plasma corticosterone levels 2 h (5 folds) and 5 h (10 folds) after CFA administration compared to sham EA control, but EA alone in naive rats and CFA alone did not induce significant increases in corticosterone.
Positive_regulation (increases) of corticosterone in plasma associated with electroacupuncture
2) Confidence 0.02 Published 2007 Journal BMC Complement Altern Med Section Abstract Doc Link PMC1976320 Disease Relevance 0.74 Pain Relevance 0.89
Other investigators have suggested that tolerance to multiple nicotine injections in mice may be due, in part, to elevated plasma corticosterone (CORT) levels, since repeated nicotine injections are associated with elevated CORT, chronically elevated CORT reduces nicotine responsiveness and adrenalectomy disrupts nicotine tolerance.
Positive_regulation (elevated) of corticosterone in plasma associated with nicotine and tolerance
3) Confidence 0.02 Published 1993 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7870994 Disease Relevance 0.07 Pain Relevance 0.62

General Comments

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