INT39837

Context Info Confidence 0.69 First Reported 1985 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 6 Total Number 8 Disease Relevance 6.20 Pain Relevance 2.06

peptidase activity (Cpn1) extracellular space (Cpn1) extracellular region (Cpn1)

Anatomy Link Frequency vein 3 spines 1 caudate-putamen 1 body 1 Cpn1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Delta opioid receptors 9 100.00 Inflammation 63 99.12 cINOD 3 96.24 Opioid 2 96.16 opioid receptor 4 95.20 mu opioid receptor 4 75.00 Endogenous opioid 1 50.96 ischemia 3 42.08 Neurotransmitter 1 25.00 Percutaneous transluminal coronary angioplasty 3 7.40

Disease Link Frequency Relevance Heat Pneumonia 153 100.00 INFLAMMATION 60 99.12 Infection 30 91.20 Atherosclerosis 15 86.64 Increased Venous Pressure Under Development 6 84.84 Hyperplasia 51 83.12 Chlamydia Infection 21 81.44 Thrombosis 9 75.80 Acute Coronary Syndrome 3 73.80 Body Weight 6 67.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Significant increase of serum CPN levels was observed in all experimental animal models with induced inflammatory conditions.

Positive_regulation (increase) of CPN associated with inflammation

1) Confidence 0.69 Published 1985 Journal Pharmacol Res Commun Section Abstract Doc Link 4048245 Disease Relevance 0.59 Pain Relevance 0.41

m in grafted vein of the control group) and showed neointimal thickening, which is principally absent in non-grafted control veins.Cpn administration immediately after vein grafting resulted in a significant increase in the medial thickness (Cpn-group: 50 ± 3 ?

Positive_regulation (increase) of Cpn in vein associated with pneumonia

2) Confidence 0.67 Published 2007 Journal BMC Microbiol Section Body Doc Link PMC2222630 Disease Relevance 0.98 Pain Relevance 0

The concurrent increase of serum CPN level during induced inflammatory conditions suggest the involvement of serum CPN as one of the body's inbuilt defensive mechanism against noxious responses or inflammation.

Positive_regulation (increase) of CPN in body associated with inflammation

3) Confidence 0.46 Published 1985 Journal Pharmacol Res Commun Section Abstract Doc Link 4048245 Disease Relevance 0.68 Pain Relevance 0.42

It is suggested that the increased serum CPN levels may be a complimentary factor associated with inflammatory conditions.

Positive_regulation (increased) of CPN associated with inflammation

4) Confidence 0.46 Published 1985 Journal Pharmacol Res Commun Section Abstract Doc Link 4048245 Disease Relevance 0.66 Pain Relevance 0.42

This is supported by the work of Bartels et al., who observed a strong correlation between elevated Cpn IgG titers and the detection of Cpn in occluded vein grafts [11].

Positive_regulation (elevated) of Cpn in vein associated with pneumonia

5) Confidence 0.45 Published 2007 Journal BMC Microbiol Section Body Doc Link PMC2222630 Disease Relevance 1.84 Pain Relevance 0.13

Cpn DNA could be detected by PCR in 25% of the cases, while viable Cpn was recovered from 16% of occluded vein grafts.

Positive_regulation (recovered) of Cpn in vein associated with pneumonia

6) Confidence 0.39 Published 2007 Journal BMC Microbiol Section Body Doc Link PMC2222630 Disease Relevance 1.45 Pain Relevance 0.03

From P15, a few immunogold particles were seen in contact with postsynaptic densities in spines, and the proportion of these particles significantly increased in P30 and adult CPN.

Positive_regulation (increased) of CPN in spines

7) Confidence 0.24 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 14608598 Disease Relevance 0 Pain Relevance 0.28

The activation of delta-opioid receptors (DORs) in the caudate-putamen nucleus (CPN) produces regionally distinct changes in motor functions, many of which are also influenced by opioids active at micro-opioid receptors (MORs).

Positive_regulation (activation) of CPN in caudate-putamen associated with opioid receptor, delta opioid receptors and opioid

8) Confidence 0.23 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11312309 Disease Relevance 0 Pain Relevance 0.37

General Comments

This test has worked.