INT39873

Context Info Confidence 0.59 First Reported 1985 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 4 Disease Relevance 1.56 Pain Relevance 0.43

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache) cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)

Anatomy Link Frequency hippocampus 3 muscle 2 cortex 1 Ache (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 18 100.00 sodium channel 2 98.68 tetrodotoxin 1 97.76 Inflammation 3 5.00 headache 3 5.00

Disease Link Frequency Relevance Heat Cognitive Disorder 66 94.84 Vomiting 6 77.68 Toxicity 3 76.96 Disease 51 62.08 Targeted Disruption 3 61.84 Dementia 9 5.00 Anxiety Disorder 9 5.00 Hepatotoxicity 6 5.00 Neurosis 6 5.00 Stroke 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This synthesis is modulated by a process associated with spontaneous muscle contractile activity since both total enzyme levels and the proportion of A12 AChE expressed on the cell surface are decreased when the cells are grown in the sodium channel blocker tetrodotoxin, which blocks muscle contraction.

Negative_regulation (decreased) of Gene_expression (expressed) of A12 AChE in muscle associated with tetrodotoxin and sodium channel

1) Confidence 0.59 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 4056799 Disease Relevance 0 Pain Relevance 0.19

We observed that the elevated expression of AChE by scopolamine in both the cortex and hippocampus was decreased by the treatment with 4-O-methylhonokiol (data not shown).

Negative_regulation (decreased) of Gene_expression (expression) of AChE in hippocampus associated with hippocampus

2) Confidence 0.58 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0.53 Pain Relevance 0.08

The inhibitory effect on the AChE activity may be related to the inhibitory effect of 4-O-methylhonokiol on the expression of AChE.

Negative_regulation (effect) of Gene_expression (expression) of AChE

3) Confidence 0.58 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0.51 Pain Relevance 0.08

We observed that the elevated expression of AChE by scopolamine in both the cortex and hippocampus was decreased by the treatment with 4-O-methylhonokiol (data not shown).

Negative_regulation (decreased) of in cortex Gene_expression (expression) of AChE in hippocampus associated with hippocampus

4) Confidence 0.20 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0.53 Pain Relevance 0.08

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