INT39873

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Context Info
Confidence 0.59
First Reported 1985
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.56
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache)
cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)
Anatomy Link Frequency
hippocampus 3
muscle 2
cortex 1
Ache (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 18 100.00 Very High Very High Very High
sodium channel 2 98.68 Very High Very High Very High
tetrodotoxin 1 97.76 Very High Very High Very High
Inflammation 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 66 94.84 High High
Vomiting 6 77.68 Quite High
Toxicity 3 76.96 Quite High
Disease 51 62.08 Quite High
Targeted Disruption 3 61.84 Quite High
Dementia 9 5.00 Very Low Very Low Very Low
Anxiety Disorder 9 5.00 Very Low Very Low Very Low
Hepatotoxicity 6 5.00 Very Low Very Low Very Low
Neurosis 6 5.00 Very Low Very Low Very Low
Stroke 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This synthesis is modulated by a process associated with spontaneous muscle contractile activity since both total enzyme levels and the proportion of A12 AChE expressed on the cell surface are decreased when the cells are grown in the sodium channel blocker tetrodotoxin, which blocks muscle contraction.
Negative_regulation (decreased) of Gene_expression (expressed) of A12 AChE in muscle associated with tetrodotoxin and sodium channel
1) Confidence 0.59 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 4056799 Disease Relevance 0 Pain Relevance 0.19
We observed that the elevated expression of AChE by scopolamine in both the cortex and hippocampus was decreased by the treatment with 4-O-methylhonokiol (data not shown).
Negative_regulation (decreased) of Gene_expression (expression) of AChE in hippocampus associated with hippocampus
2) Confidence 0.58 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0.53 Pain Relevance 0.08
The inhibitory effect on the AChE activity may be related to the inhibitory effect of 4-O-methylhonokiol on the expression of AChE.
Negative_regulation (effect) of Gene_expression (expression) of AChE
3) Confidence 0.58 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0.51 Pain Relevance 0.08
We observed that the elevated expression of AChE by scopolamine in both the cortex and hippocampus was decreased by the treatment with 4-O-methylhonokiol (data not shown).
Negative_regulation (decreased) of in cortex Gene_expression (expression) of AChE in hippocampus associated with hippocampus
4) Confidence 0.20 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0.53 Pain Relevance 0.08

General Comments

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