INT39902

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Context Info
Confidence 0.46
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.54
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Anatomy Link Frequency
hepatocytes 2
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 6 99.98 Very High Very High Very High
Hippocampus 11 74.16 Quite High
ischemia 20 50.00 Quite Low
alcohol 2 46.60 Quite Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 28 98.36 Very High Very High Very High
Urological Neuroanatomy 11 75.68 Quite High
Brain Hemorrhage 6 50.00 Quite Low
Cv General 4 Under Development 10 40.00 Quite Low
Injury 10 36.40 Quite Low
Poisoning 3 13.04 Low Low
Body Weight 14 5.00 Very Low Very Low Very Low
Reperfusion Injury 10 5.00 Very Low Very Low Very Low
Hepatotoxicity 9 5.00 Very Low Very Low Very Low
Stroke 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The acetaminophen-induced GSH depletion and ensuing lactate dehydrogenase (LDH) leakage were quite modest and delayed in onset, in contrast to that caused by iodoacetamide (IAA) and by diethylmaleate (DEM), 2 well-known depletors of GSH.
Positive_regulation (induced) of Negative_regulation (depletion) of lactate dehydrogenase associated with paracetamol
1) Confidence 0.46 Published 1985 Journal Toxicology Section Abstract Doc Link 4060164 Disease Relevance 0 Pain Relevance 0.42
A significant (P < 0.01) increase in the activity of LDH in serum was observed in the ischemic (MCAO) group rats, as compared to the sham group; whereas, aqueous extract of Embelia ribes treatment significantly (P < 0.01) resulted in decreased serum LDH levels when compared with the ischemic (MCAO) group rats.
Positive_regulation (resulted) of Negative_regulation (decreased) of LDH associated with middle cerebral artery infarction
2) Confidence 0.34 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792627 Disease Relevance 0.54 Pain Relevance 0.04
A significant increase in the levels of ASAT, ALAT, ALP, total bilirubin, LDH (P < 0.001) and a significant reduction in the levels of TGL, total proteins, and albumin (P < 0.001) were observed in hepatocytes exposed to CCl4 when compared to normal rats.
Positive_regulation (increase) of Negative_regulation (reduction) of LDH in hepatocytes
3) Confidence 0.12 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2907024 Disease Relevance 0 Pain Relevance 0

General Comments

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