INT39997

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Context Info
Confidence 0.59
First Reported 1985
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 6.38
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Gla) extracellular region (Gla) Golgi apparatus (Gla)
lysosome (Gla) cytoplasm (Gla)
Anatomy Link Frequency
AGS 5
plasma 1
endothelial cells 1
peripheral nervous system 1
Gla (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 5 98.96 Very High Very High Very High
Peripheral nervous system 4 98.36 Very High Very High Very High
Neuropathic pain 2 97.16 Very High Very High Very High
Pain 3 95.68 Very High Very High Very High
Eae 2 85.44 High High
hypoalgesia 4 83.20 Quite High
Serotonin 10 82.44 Quite High
monoamine 5 81.16 Quite High
palliative 1 74.16 Quite High
Sciatic nerve 2 68.72 Quite High
Disease Link Frequency Relevance Heat
Alagille Syndrome 40 100.00 Very High Very High Very High
Syndrome 10 99.78 Very High Very High Very High
Metabolic Disorder 1 99.74 Very High Very High Very High
Fabry Disease 18 99.06 Very High Very High Very High
Neuropathic Pain 2 97.16 Very High Very High Very High
Renal Failure 2 96.28 Very High Very High Very High
Pain 1 95.68 Very High Very High Very High
Angiokeratoma 3 93.48 High High
Disease 2 91.80 High High
Death 1 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Demonstration of alpha-galactosidase A deficiency in leukocytes or plasma is the definitive method for the diagnosis of affected hemizygous males.
Negative_regulation (deficiency) of alpha-galactosidase in plasma
1) Confidence 0.59 Published 2000 Journal Rev Med Interne Section Abstract Doc Link 11191676 Disease Relevance 0.74 Pain Relevance 0.10
Loss of alpha-galactosidase (alpha-Gal) activity leads to the abnormal accumulation of glycosphingolipids in lysosomes predominantly of vascular endothelial cells.
Negative_regulation (Loss) of alpha-galactosidase in endothelial cells
2) Confidence 0.58 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 18848893 Disease Relevance 0.46 Pain Relevance 0.13
In this study, we investigated the implications of loss of alpha-galactosidase A activity on sensorimotor function and peripheral nervous system.
Spec (investigated) Negative_regulation (loss) of alpha-galactosidase in peripheral nervous system associated with peripheral nervous system
3) Confidence 0.58 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 18848893 Disease Relevance 0.64 Pain Relevance 0.31
Fabry disease is an X-linked metabolic disorder caused by a deficiency of alpha-galactosidase A (alpha-Gal A).
Negative_regulation (deficiency) of alpha-galactosidase A associated with metabolic disorder and fabry disease
4) Confidence 0.57 Published 2001 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 11758676 Disease Relevance 0.43 Pain Relevance 0.07
Combined administration of clorgyline plus deprenyl also suppressed AGS.
Negative_regulation (suppressed) of AGS in AGS associated with alagille syndrome
5) Confidence 0.46 Published 1985 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 4080761 Disease Relevance 0.80 Pain Relevance 0.20
These results suggest, first of all, that the inhibition of AGS produced by 6-MeO-THBC is a consequence of its combined MAO-A and 5-HT uptake inhibition properties.
Negative_regulation (inhibition) of AGS in AGS associated with alagille syndrome
6) Confidence 0.34 Published 1985 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 4080761 Disease Relevance 0.91 Pain Relevance 0.17
Combination of a specific 5-HT uptake inhibitor (fluoxetine or citalopram) with the MAO-A inhibitor clorgyline inhibited AGS more effectively than the individual drugs but combination with the MAO-B inhibitor deprenyl did not.
Negative_regulation (inhibited) of AGS in AGS associated with alagille syndrome and fluoxetine
7) Confidence 0.34 Published 1985 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 4080761 Disease Relevance 0.74 Pain Relevance 0.22
Secondly, the similarity of results of pharmacological manipulations of the 5-HT system which produce the rat motor syndrome and which inhibit AGS in the mouse suggests that AGS in 21-day-old DBA/2J mice may be a useful system for assessing functional consequences of these serotonergic manipulations.
Negative_regulation (inhibit) of AGS in AGS associated with alagille syndrome and syndrome
8) Confidence 0.34 Published 1985 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 4080761 Disease Relevance 0.80 Pain Relevance 0.10
Inhibition of AGS by tryptophan was potentiated by combination with either of the mixed MAO inhibitors nialamide or tranylcypromine.
Negative_regulation (Inhibition) of AGS in AGS associated with alagille syndrome
9) Confidence 0.34 Published 1985 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 4080761 Disease Relevance 0.85 Pain Relevance 0.20

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