INT4015

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Context Info
Confidence 0.37
First Reported 1975
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 6.45
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCTR) signal transducer activity (SCTR)
Anatomy Link Frequency
Heart 2
SCTR (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 6 100.00 Very High Very High Very High
Chronic pancreatitis 5 98.36 Very High Very High Very High
tolerance 5 92.16 High High
alcohol 3 87.00 High High
abdominal pain 2 80.52 Quite High
fibrosis 19 77.00 Quite High
Cholecystokinin 1 75.00 Quite High
beta blocker 3 54.08 Quite High
sodium channel 3 48.08 Quite Low
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Pancreatitis 18 99.68 Very High Very High Very High
Arrhythmias 2 Under Development 333 98.88 Very High Very High Very High
Heart Rate Under Development 75 97.04 Very High Very High Very High
Alcohol Addiction 2 96.84 Very High Very High Very High
Gallstones 1 95.68 Very High Very High Very High
Disease 10 95.08 Very High Very High Very High
Ulcers 1 94.36 High High
Impaired Glucose Tolerance 2 92.80 High High
Myocardial Infarction 12 91.86 High High
Arrhythmia Under Development 48 89.30 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to study whether or not mucosubstance increases occur in the pancreatic juice of patients with chronic pancreatitis, hexosamine was measured in duodenal aspirates during the secretin phase (S-40) following pancreozymin-secretin stimulation in 16 normal subjects, 37 patients with chronic pancreatitis, 6 patients with alcoholism, 13 patients with gallstones, and 11 patients with peptic ulcer.
Positive_regulation (stimulation) of pancreozymin-secretin associated with alcohol addiction, bile, ulcers, gallstones and chronic pancreatitis
1) Confidence 0.37 Published 1976 Journal Am J Dig Dis Section Abstract Doc Link 952274 Disease Relevance 0.82 Pain Relevance 0.42
The Cardiac Arrhythmia Suppression Trial (CAST) results, published in 1991, showed increased mortality in patients surviving myocardial infarction (MI),18 and caused sales of class IC antiarrhythmic drugs (AADs) to fall dramatically (by 75%) and there has been a considerable decrease since 1995 in the prescribing of class I AADs in favour of class III AADs.19,20 However, the use of flecainide is supported by results from many randomized clinical trials, and the drug is recommended as a first-line treatment option for pharmacological cardioversion and maintenance of SR in the American College of Cardiology/American Heart Association/European Society of Cardiology (ACC/AHA/ESC) 2006 guidelines as well as in the 2010 update of the ESC's European guidelines.3,4 This review aims to examine the 27 years of accumulated data on flecainide's safety and efficacy, and place the drug in its therapeutic context.
Positive_regulation (maintenance) of SR in Heart associated with arrhythmia under development and myocardial infarction
2) Confidence 0.03 Published 2011 Journal Europace Section Body Doc Link PMC3024037 Disease Relevance 0.83 Pain Relevance 0
The availability of new data from recent clinical trials prompted an update of the ESC European guidelines4 to include dronedarone as a recommended first-line treatment option for maintenance of SR in patients with paroxysmal and persistent AF, except those patents with congestive heart failure New York Heart Association (NYHA) class III/IV or unstable congestive heart failure NYHA class II.
Positive_regulation (maintenance) of SR in heart associated with heart rate under development and arrhythmias 2 under development
3) Confidence 0.03 Published 2011 Journal Europace Section Body Doc Link PMC3024037 Disease Relevance 1.77 Pain Relevance 0
In haemodynamically stable patients with acute-onset AF (<48 h duration) and preserved LV function, flecainide restores SR in up to 95% of patients within 1h from the start of the infusion.
Positive_regulation (restores) of SR associated with arrhythmias 2 under development
4) Confidence 0.03 Published 2011 Journal Europace Section Body Doc Link PMC3024037 Disease Relevance 0.30 Pain Relevance 0.03
A mild attack of pancreatitis occurred after secretin-pancreozymin stimulation.
Positive_regulation (stimulation) of secretin-pancreozymin associated with bile and pancreatitis
5) Confidence 0.01 Published 1975 Journal Pediatrics Section Abstract Doc Link 1110867 Disease Relevance 1.23 Pain Relevance 0.49
A mild attack of pancreatitis occurred after secretin-pancreozymin stimulation.
Positive_regulation (stimulation) of secretin-pancreozymin associated with bile and pancreatitis
6) Confidence 0.01 Published 1975 Journal Pediatrics Section Abstract Doc Link 1110867 Disease Relevance 1.23 Pain Relevance 0.49
Nineteen patients of group CP underwent pancreozymin-secretin and NBT-PABA tests.
Positive_regulation (underwent) of pancreozymin-secretin associated with bile
7) Confidence 0.00 Published 1984 Journal Am. J. Gastroenterol. Section Abstract Doc Link 6332529 Disease Relevance 0.27 Pain Relevance 0.19

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