INT4036

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Context Info
Confidence 0.45
First Reported 1976
Last Reported 1990
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.92
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gip) extracellular region (Gip) cytoplasm (Gip)
Anatomy Link Frequency
fat 2
duodenum 2
Gip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 7 99.44 Very High Very High Very High
Chronic pancreatitis 8 97.84 Very High Very High Very High
Paracetamol 2 59.32 Quite High
Disease Link Frequency Relevance Heat
Hyperinsulinism 1 99.52 Very High Very High Very High
Impaired Glucose Tolerance 9 99.44 Very High Very High Very High
Pancreatitis 8 97.84 Very High Very High Very High
Steatorrhea 3 91.92 High High
Disease 4 83.08 Quite High
Celiac Disease 4 82.76 Quite High
Obesity 1 38.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In chronic pancreatitis endocrine insufficiency may induce an exaggerated GIP response and severe exocrine insufficiency may prevent fat induced GIP release.
Positive_regulation (induced) of Localization (release) of GIP in fat associated with chronic pancreatitis
1) Confidence 0.45 Published 1976 Journal Diabetologia Section Abstract Doc Link 1001849 Disease Relevance 0.33 Pain Relevance 0.34
The failure of sugar-beet fibre to reduce post-prandial insulin secretion despite improved glucose tolerance may be due to the observed increased secretion of GIP.
Spec (observed) Positive_regulation (increased) of Spec (observed) Localization (secretion) of GIP associated with tolerance and impaired glucose tolerance
2) Confidence 0.37 Published 1990 Journal Br. J. Nutr. Section Abstract Doc Link 2169302 Disease Relevance 0.43 Pain Relevance 0.27
The influence of impaired digestion on nutrient induced release of gastric inhibitory polypeptide (GIP) and insulin have been investigated in patients with chronic pancreatitis.
Positive_regulation (induced) of Localization (release) of GIP associated with chronic pancreatitis
3) Confidence 0.37 Published 1980 Journal Diabetologia Section Abstract Doc Link 6997121 Disease Relevance 0.41 Pain Relevance 0.13
This demonstrates that the duodenum is not necessary for GIP release and that pancreatic and jejunal gastrin are without clinical significance.
Neg (not) Positive_regulation (necessary) of Localization (release) of GIP in duodenum
4) Confidence 0.36 Published 1976 Journal Diabetologia Section Abstract Doc Link 955338 Disease Relevance 0.74 Pain Relevance 0.16

General Comments

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