INT4057

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Context Info
Confidence 0.32
First Reported 1976
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.28
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptgfr) plasma membrane (Ptgfr) signal transducer activity (Ptgfr)
Anatomy Link Frequency
blood 2
Plasma 1
outflow 1
uterine 1
PGE2 1
Ptgfr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 51 100.00 Very High Very High Very High
Dismenorea 16 99.54 Very High Very High Very High
Serotonin 6 98.40 Very High Very High Very High
aspirin 23 97.88 Very High Very High Very High
diclofenac 2 93.64 High High
Pain 6 86.44 High High
cINOD 2 75.44 Quite High
Analgesic 4 73.60 Quite High
anesthesia 2 57.76 Quite High
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 7 99.80 Very High Very High Very High
Arrhythmogenic Right Ventricular Dysplasia 4 99.78 Very High Very High Very High
Dysmenorrhea 3 99.54 Very High Very High Very High
Heart Rate Under Development 4 95.80 Very High Very High Very High
Body Weight 1 91.92 High High
Arrhythmia Under Development 4 91.08 High High
Natriuresis 2 90.80 High High
Pressure Volume 2 Under Development 2 87.04 High High
Pain 6 86.44 High High
Reprotox - General 1 9 86.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the critical time, at around parturition, when the myometrium is converted from a suppressed and refractory muscle into a spontaneously active and reactive organ (quantitated by recording the IUP), the uterine PGE and PGF levels decreased rather than increased (quantitated by RIA).
Negative_regulation (decreased) of PGF in uterine associated with dismenorea
1) Confidence 0.32 Published 1976 Journal Prostaglandins Section Abstract Doc Link 959574 Disease Relevance 0.25 Pain Relevance 0.25
The PGF-M decrease during the naproxen sodium treatment was significantly more prominent than that during both aspirin and placebo treatments (p = 0.0001).
Negative_regulation (decrease) of PGF-M associated with aspirin
2) Confidence 0.09 Published 1981 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 7246695 Disease Relevance 0.29 Pain Relevance 0.84
During naproxen sodium treatment, the mean blood PGF-M levels decreased by 73.5%, from a mean of 50.5 to 13.4 pg/ml; during aspirin treatment they decreased by 31.2%, from a mean of 44.2 to 30.4 pg/ml; during placebo treatment, an increase of 13.6% was observed, from a mean of 46.3 to 52.6 pg/ml.
Negative_regulation (decreased) of PGF-M in blood associated with aspirin
3) Confidence 0.09 Published 1981 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 7246695 Disease Relevance 0.31 Pain Relevance 0.76
On Mg-therapy conditions we achieved a reduction of PGF2 alpha in menstrual blood to 45% of value before treatment started.
Negative_regulation (reduction) of PGF2 in blood
4) Confidence 0.07 Published 1989 Journal Zentralbl Gynakol Section Abstract Doc Link 2675496 Disease Relevance 0.16 Pain Relevance 0.23
The ventricular arrhythmogenic effect of PGF2 alpha was prevented by propranolol (1 mg/kg i.v.).
Negative_regulation (prevented) of PGF2 associated with arrhythmogenic right ventricular dysplasia
5) Confidence 0.05 Published 1989 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2636814 Disease Relevance 0.98 Pain Relevance 0
(Fig. 6C) -induced activation of CRE Luciferase was significantly inhibited by co-treatment of cells with the FP receptor antagonist (AL8810) or chemical inhibitors of PLC (U73122), PKA (4C3MQ), EGFR kinase (AG1478) and ERK1/2 kinase (PD98059), but not the EP2 receptor antagonist (AH6809), EP4 receptor antagonist (ONOAE2227) or PKC inhibitor (GF109203x; Fig. 6C; P < 0.05).


Negative_regulation (inhibitors) of FP receptor associated with antagonist
6) Confidence 0.03 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.22 Pain Relevance 0.29
The mean urinary PGE2 and PGF2 excretion was reduced by 35-63% and 63-85%, respectively.
Negative_regulation (reduced) of PGF2 in PGE2
7) Confidence 0.02 Published 1980 Journal Acta Pharmacol Toxicol (Copenh) Section Abstract Doc Link 7361561 Disease Relevance 0.24 Pain Relevance 0.28
Plasma levels of 6-keto-PGF1 alpha and serotonin increased only to 131 and 149% of control at 50 min of infusion, and levels of PGF2 alpha and TxB2 decreased to 50 and 80% of control at 100 and 150 min of infusion, respectively.
Negative_regulation (decreased) of PGF2 in Plasma associated with serotonin
8) Confidence 0.01 Published 1985 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 3867760 Disease Relevance 0.15 Pain Relevance 0.30
The results of the present investigation suggest that PGF2 alpha decreases the intraocular pressure by increasing the uveoscleral outflow.
Negative_regulation (decreases) of PGF2 in outflow associated with ocular hypertension
9) Confidence 0.00 Published 1989 Journal Exp. Eye Res. Section Abstract Doc Link 2737263 Disease Relevance 0.70 Pain Relevance 0.06

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