INT4074

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Context Info
Confidence 0.59
First Reported 1976
Last Reported 1982
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.61
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Dbh) cytoplasm (Dbh)
Anatomy Link Frequency
neurons 6
nerve 2
Dbh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 7 100.00 Very High Very High Very High
Enkephalin 8 99.82 Very High Very High Very High
Hippocampus 3 98.52 Very High Very High Very High
Morphine 3 94.64 High High
anesthesia 3 80.16 Quite High
narcan 3 72.16 Quite High
antagonist 1 69.20 Quite High
opiate 2 46.16 Quite Low
Disease Link Frequency Relevance Heat
Stress 9 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since noradrenergic neurons in the brain appear to inhibit ACTH secretion and dopamine-beta-hydroxylase (DBH) is found in noradrenergic neurons, the effect of variations in pituitary-adrenal activity on the activity of DBH in the brain stem, hypothalamus and hippocampus was determined.
Negative_regulation (inhibit) of Localization (secretion) of dopamine-beta-hydroxylase in neurons associated with dopamine and hippocampus
1) Confidence 0.59 Published 1976 Journal Neuroendocrinology Section Abstract Doc Link 967301 Disease Relevance 0.19 Pain Relevance 0.21
Since noradrenergic neurons in the brain appear to inhibit ACTH secretion and dopamine-beta-hydroxylase (DBH) is found in noradrenergic neurons, the effect of variations in pituitary-adrenal activity on the activity of DBH in the brain stem, hypothalamus and hippocampus was determined.
Negative_regulation (inhibit) of Localization (secretion) of DBH in neurons associated with dopamine and hippocampus
2) Confidence 0.43 Published 1976 Journal Neuroendocrinology Section Abstract Doc Link 967301 Disease Relevance 0.20 Pain Relevance 0.21
Since noradrenergic neurons in the brain appear to inhibit ACTH secretion and dopamine-beta-hydroxylase (DBH) is found in noradrenergic neurons, the effect of variations in pituitary-adrenal activity on the activity of DBH in the brain stem, hypothalamus and hippocampus was determined.
Negative_regulation (inhibit) of Localization (secretion) of DBH in neurons associated with dopamine and hippocampus
3) Confidence 0.43 Published 1976 Journal Neuroendocrinology Section Abstract Doc Link 967301 Disease Relevance 0.22 Pain Relevance 0.22
These changes were paralleled by significant dose-dependent Met-enkephalin-induced decreases in the nerve stimulation-mediated release of total 3H, DBH and in the perfusion pressure.
Negative_regulation (decreases) of Localization (release) of DBH in nerve associated with enkephalin
4) Confidence 0.19 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6281410 Disease Relevance 0 Pain Relevance 0.85

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