INT40877

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Context Info
Confidence 0.68
First Reported 1982
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 32.47
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (APOB) small molecule metabolic process (APOB) endoplasmic reticulum (APOB)
enzyme binding (APOB) lipid metabolic process (APOB) extracellular space (APOB)
Anatomy Link Frequency
plasma 4
hepatocytes 1
APOB (Homo sapiens)
APOB - T309V (1)
Pain Link Frequency Relevance Heat
addiction 23 99.98 Very High Very High Very High
rheumatoid arthritis 56 98.80 Very High Very High Very High
corticosteroid 7 96.32 Very High Very High Very High
imagery 14 95.56 Very High Very High Very High
depression 4 95.08 Very High Very High Very High
Inflammation 155 93.40 High High
Inflammatory marker 11 90.88 High High
Angina 14 88.16 High High
beta blocker 10 75.00 Quite High
Morphine 18 66.84 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 782 100.00 Very High Very High Very High
Familial Combined Hyperlipidemia 254 99.92 Very High Very High Very High
Cardiovascular Disease 374 99.90 Very High Very High Very High
Hyperlipidemia 72 99.88 Very High Very High Very High
Nicotine Addiction 133 99.80 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

139 99.58 Very High Very High Very High
Obesity 201 99.24 Very High Very High Very High
Diabetes Mellitus 285 98.84 Very High Very High Very High
Rheumatoid Arthritis 56 98.80 Very High Very High Very High
Metabolic Syndrome 246 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our study, patients with prominent CVD had elevated serum apoB and Lp(a) levels and apoB/apoA-I ratio values, as well as lower serum levels of apoA-I compared to patients without prevalent CVD.
Positive_regulation (elevated) of apoB associated with cardiovascular disease
1) Confidence 0.68 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 0.82 Pain Relevance 0
Moreover, although in many conditions LDL cholesterol and apoB levels increase in parallel (e.g. familial hypercholesterolaemia), in ESRD patients, due to hypertriglyceridemia, malnutrition or metabolic disturbances, LDL-C levels are often phenomenically ‘normal,’ as in our study, yet apoB levels are rather elevated due to its overproduction and this results in the formation of a small, dense form of LDL (pattern B phenotype).
Positive_regulation (increase) of apoB associated with appetite loss, chronic renal failure and hyperlipidemia
2) Confidence 0.68 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 1.24 Pain Relevance 0.19
VLDL apolipoprotein-B was markedly increased by propranolol (67%), whereas apolipoprotein-A was slightly (8%) increased during metoprolol treatment.
Positive_regulation (increased) of apolipoprotein-B associated with disorder of lipid metabolism
3) Confidence 0.67 Published 1982 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 6125482 Disease Relevance 0.46 Pain Relevance 0.13
It is the country with lowest mean age at incidence of AMI, and among INTERHEART control subjects, it has the highest prevalence of most risk factors studied: current and former smoking (59.9%), elevated apolipoprotein B100 (ApoB100)/apolipoprotein A-I (ApoA-I) ratio (59.7%), abdominal obesity (43.3%), self-reported history of hypertension (14.3%), and depression (43.0%).
Positive_regulation (elevated) of ApoB100 associated with nicotine addiction, depression, hypertension, metabolic syndrome, disorder of lipid metabolism and myocardial infarction
4) Confidence 0.67 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2742703 Disease Relevance 1.02 Pain Relevance 0.05
Such dyslipidemia is also characterized by increased levels of atherogenic lipoproteins including, elevated apo B, and small, dense LDL and HDL particles (Tchernof et al 1996).
Positive_regulation (increased) of apo B associated with disorder of lipid metabolism
5) Confidence 0.54 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 1.63 Pain Relevance 0
In group B the increase of TG was accounted for by men and the increased LDL and apoB concentrations were to a larger part accounted for by women.
Positive_regulation (increased) of apoB
6) Confidence 0.51 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2768711 Disease Relevance 0.13 Pain Relevance 0
Apo B was also slightly increased in group B but not in group A after intake.
Neg (not) Positive_regulation (increased) of Apo B
7) Confidence 0.51 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2768711 Disease Relevance 0.37 Pain Relevance 0
One can therefore argue that formulation A may have counteracted an increase in total cholesterol, apoB and TG, related mainly to an increased energy intake which provides some support for a positive effect of the milk polar lipids.
Positive_regulation (increase) of apoB associated with disorder of lipid metabolism
8) Confidence 0.51 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2768711 Disease Relevance 0.18 Pain Relevance 0
The ApoB100/ApoA-I ratio provides an atherogenic to antiatherogenic lipoprotein ratio that has been shown to be a better predictor of CVD than LDL level, HDL level or LDL/HDL ratio.74–77 Furthermore, the ApoB100/ApoA-I ratio can identify individuals with a preponderance of small dense LDL particles, but with seemingly normal LDL levels.78 INTERHEART was among the first studies to demonstrate that an elevated ApoB100/ApoA-I ratio was the risk factor associated with the highest PAR (46.8%) for AMI in South Asians, with WHR (37.7%) and current and former smoking (37.5%) following close behind.26
Positive_regulation (elevated) of ApoB100 associated with nicotine addiction, cardiovascular disease, myocardial infarction and disorder of lipid metabolism
9) Confidence 0.49 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2742703 Disease Relevance 0.98 Pain Relevance 0
In 1986, the APOB gene, its mRNA and the apo B content of the hepatocytes were found to be normal in ABL patients, suggesting that defective post-translational processing and secretion of apo B was the cause of ABL [3].
Positive_regulation (normal) of APOB in hepatocytes
10) Confidence 0.47 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.74 Pain Relevance 0
Moreover, although in many conditions LDL cholesterol and apoB levels increase in parallel (e.g. familial hypercholesterolaemia), in ESRD patients, due to hypertriglyceridemia, malnutrition or metabolic disturbances, LDL-C levels are often phenomenically ‘normal,’ as in our study, yet apoB levels are rather elevated due to its overproduction and this results in the formation of a small, dense form of LDL (pattern B phenotype).
Positive_regulation (elevated) of apoB associated with appetite loss, chronic renal failure and hyperlipidemia
11) Confidence 0.46 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 1.12 Pain Relevance 0.14
One cannot discriminate, however, from the data of our study whether there is absolute lack of an effect or whether apoB levels remain eventually elevated due to counter-acting effects of overproduction of apoB, which is known to occur in HD patients (Chan et al. 1989), and a probable apoB-lowering effect of systemic inflammation and malnutrition.
Spec (whether) Positive_regulation (elevated) of apoB associated with appetite loss and inflammation
12) Confidence 0.46 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 1.09 Pain Relevance 0.21
VLDL apolipoprotein-B was markedly increased by propranolol (67%), whereas apolipoprotein-A was slightly (8%) increased during metoprolol treatment.
Positive_regulation (increased) of apolipoprotein-B associated with disorder of lipid metabolism
13) Confidence 0.45 Published 1982 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 6125482 Disease Relevance 0.46 Pain Relevance 0.13
In addition, ERA patients exhibited a mild dyslipidemia characterized by an increase in the serum levels of total cholesterol, LDL-cholesterol, triglycerides and Apo B as well as by a decrease in the serum levels of HDL-cholesterol and Apo A-I compared with controls.
Positive_regulation (increase) of Apo B associated with rheumatoid arthritis and disorder of lipid metabolism
14) Confidence 0.38 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860077 Disease Relevance 1.44 Pain Relevance 0.30
The population average ApoB/ApoA1 ratio (BARP) can be estimated from values for the age and gender-adjusted estimates of TC and HDL using the coefficients in Additional file 1, thus:
Positive_regulation (population) of ApoB associated with disorder of lipid metabolism
15) Confidence 0.37 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2601038 Disease Relevance 1.44 Pain Relevance 0
The population average ApoB/ApoA1 ratio (BARP) can be estimated from values for the age and gender-adjusted estimates of TC and HDL using the coefficients in Additional file 1, thus:
Positive_regulation (estimated) of ApoB associated with disorder of lipid metabolism
16) Confidence 0.37 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2601038 Disease Relevance 1.43 Pain Relevance 0
Such dyslipidemia is also characterized by increased levels of atherogenic lipoproteins including, elevated apo B, and small, dense LDL and HDL particles (Tchernof et al 1996).
Positive_regulation (elevated) of apo B associated with disorder of lipid metabolism
17) Confidence 0.36 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 1.55 Pain Relevance 0
In group B TG, cholesterol, LDL, HDL and apolipoprotein B concentrations increased, however, but not in group A after four weeks.
Neg (not) Positive_regulation (increased) of apolipoprotein B associated with disorder of lipid metabolism
18) Confidence 0.34 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2768711 Disease Relevance 0.28 Pain Relevance 0
There were, however, trends towards increased concentrations of total plasma cholesterol, LDL, HDL, apo B and TG in group B, which were not seen in group A.
Positive_regulation (increased) of apo B in plasma associated with disorder of lipid metabolism
19) Confidence 0.34 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2768711 Disease Relevance 0.22 Pain Relevance 0.06
There was a minor increase in the apoB/apoA1 ratios in both groups (Figure 4).
Positive_regulation (increase) of apoB
20) Confidence 0.34 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2768711 Disease Relevance 0.46 Pain Relevance 0

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