INT40979

Context Info Confidence 0.40 First Reported 1982 Last Reported 2011 Negated 0 Speculated 1 Reported most in Abstract Documents 20 Total Number 21 Disease Relevance 8.71 Pain Relevance 4.06

cytoplasm (Aats-gln)

Anatomy Mention Frequency sinus 1 pulmonary valve 1 Aats-gln (Drosophila melanogaster)

Pain Term Frequency Confidence Heat cocaine 18 99.56 lidocaine 34 99.34 depression 2 98.96 tolerance 3 93.48 sodium channel 8 78.72 anesthesia 2 70.44 alcohol 2 70.40 Angina 7 67.08 ischemia 5 65.00 beta blocker 4 60.44

Disease Term Frequency Confidence Heat Cv General 2 Under Development 17 100.00 Arrhythmias 2 Under Development 173 99.98 Heart Rate Under Development 85 99.88 Depression 2 98.96 Myocardial Infarction 55 97.24 Infarction 1 96.80 Pressure And Volume Under Development 21 96.64 Sudden Death 24 95.28 Arrhythmia Under Development 36 94.64 Pulmonary Disease 3 94.60

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Pain term

Disease term

However, in some studies LV pacing without reduction of the QRS duration was more beneficial than biventricular pacing with marked reduction in QRS duration [10].

Negative_regulation (reduction) of QRS

1) Confidence 0.40 Published 2003 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1513520 Disease Relevance 0 Pain Relevance 0

However, it is controversial whether conduction delay increases or decreases the HF-QRS.

Spec (whether) Negative_regulation (decreases) of QRS associated with arrhythmias 2 under development

2) Confidence 0.37 Published 1998 Journal Jpn. Circ. J. Section Abstract Doc Link 9856601 Disease Relevance 0.27 Pain Relevance 0.14

This study proved that conduction delay decreases the HF-QRS, and that the HF-QRS is a potent indicator of disturbed local conduction.

Negative_regulation (decreases) of QRS associated with arrhythmias 2 under development

3) Confidence 0.37 Published 1998 Journal Jpn. Circ. J. Section Abstract Doc Link 9856601 Disease Relevance 0.39 Pain Relevance 0.25

Activation time (AT; dV/dt minimum) was delayed and the HF-QRS was reduced in the area perfused by flecainide, lidocaine or disopyramide.

Negative_regulation (reduced) of QRS associated with lidocaine

4) Confidence 0.37 Published 1998 Journal Jpn. Circ. J. Section Abstract Doc Link 9856601 Disease Relevance 0.37 Pain Relevance 0.27

Decrease in the HF-QRS linearly correlated with the local conduction delay.

Negative_regulation (Decrease) of QRS associated with arrhythmias 2 under development

5) Confidence 0.37 Published 1998 Journal Jpn. Circ. J. Section Abstract Doc Link 9856601 Disease Relevance 0.40 Pain Relevance 0.26

The percent increase in AT closely correlated the percentage decrease in the HF-QRS; the correlation coefficients were 0.75, 0.83 and 0.76 for flecainide, lidocaine and disopyramide infusion, respectively, (p<0.001).

Negative_regulation (decrease) of QRS associated with lidocaine

6) Confidence 0.37 Published 1998 Journal Jpn. Circ. J. Section Abstract Doc Link 9856601 Disease Relevance 0.38 Pain Relevance 0.27

Decrease in the high frequency QRS components depending on the local conduction delay.

Negative_regulation (Decrease) of QRS associated with arrhythmias 2 under development

7) Confidence 0.37 Published 1998 Journal Jpn. Circ. J. Section Title Doc Link 9856601 Disease Relevance 0.39 Pain Relevance 0.21

Addition of sodium bicarbonate to increase the pH of the perfusate from 7.37 +/- 0.09 to 7.52 +/- 0.08 (p < 0.01) decreased the QRS duration from 38 +/- 4 to 30 +/- 6 msec (p < 0.01), a 47% reversal.

Negative_regulation (decreased) of QRS

8) Confidence 0.37 Published 1994 Journal Pharmacotherapy Section Abstract Doc Link 7885973 Disease Relevance 0 Pain Relevance 0.85

The addition of lidocaine to cocaine-containing perfusate decreased QRS duration from 42 +/- 3 to 29 +/- 3 msec (p < 0.01), a 60% reversal.

Negative_regulation (decreased) of QRS associated with lidocaine and cocaine

9) Confidence 0.37 Published 1994 Journal Pharmacotherapy Section Abstract Doc Link 7885973 Disease Relevance 0 Pain Relevance 0.84

Lidocaine caused incomplete block in the accessory pathway (reduction of the number of the aberrant QRS) and significant reduction of the average ventricular rate in all tested subjects.

Negative_regulation (reduction) of QRS associated with lidocaine

10) Confidence 0.33 Published 1982 Journal G Ital Cardiol Section Abstract Doc Link 6130024 Disease Relevance 0.45 Pain Relevance 0.10

However, in some studies LV pacing without reduction of the QRS duration was more beneficial than biventricular pacing with marked reduction in QRS duration [10].

Negative_regulation (reduction) of QRS

11) Confidence 0.29 Published 2003 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1513520 Disease Relevance 0 Pain Relevance 0

The admission ECG showed sinus tachycardia with reduction of the amplitude of the QRS complexes and ST-segment depression in leads V4 to V6 (<1 mm).

Negative_regulation (reduction) of QRS in sinus associated with heart rate under development and depression

12) Confidence 0.23 Published 2003 Journal World J Surg Oncol Section Body Doc Link PMC280706 Disease Relevance 1.67 Pain Relevance 0.15

In contrast, addition of lidocaine to aprindine (n = 17) showed a subtractive effect; the QRS prolongation was attenuated significantly by 1.6-2.4% at rates < 150 ppm.

Negative_regulation (attenuated) of QRS associated with lidocaine

13) Confidence 0.23 Published 1995 Journal Eur. Heart J. Section Abstract Doc Link 7588928 Disease Relevance 0 Pain Relevance 0.38

A narrow QRS denotes an origin above the Bundle of His and the converse is true in wide QRS complete atrioventricular block.

Negative_regulation (block) of QRS associated with cv general 2 under development

14) Confidence 0.17 Published 2010 Journal JRSM Short Reports Section Body Doc Link PMC2994351 Disease Relevance 0.56 Pain Relevance 0

The computer-based analysis demonstrated no significant statistical change in the QTc interval but a significant statistical decrease in the RR and QRS interval after each application of EP pulses (Table 2).

Negative_regulation (decrease) of QRS

15) Confidence 0.11 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2491703 Disease Relevance 0.25 Pain Relevance 0

Oosterhof et al demonstrated that late pulmonary valve replacement resulted in a transient decrease in QRS duration, but without long-term effect.

Negative_regulation (decrease) of QRS in pulmonary valve

16) Confidence 0.09 Published 2010 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2880870 Disease Relevance 0.58 Pain Relevance 0

The recovery time of this reduction in the high-frequency QRS potentials correlated with the duration of aortic cross-clamping (r = 0.80, p = 0.0009) and the value of postoperative MB isozyme of the creatine kinase (r = 0.81, p = 0.0042).

Negative_regulation (reduction) of QRS

17) Confidence 0.09 Published 2001 Journal Pediatr Cardiol Section Abstract Doc Link 11455399 Disease Relevance 0.07 Pain Relevance 0.10

During treatment, the QRS interval should be regularly monitored.3

Negative_regulation (monitored.3) of QRS

18) Confidence 0.02 Published 2011 Journal Europace Section Body Doc Link PMC3024037 Disease Relevance 1.15 Pain Relevance 0.05

New-onset of Q waves on the post-interventional ECG is defined as an initial negative deflection of the QRS complex of >0.1 mV and >40 ms in an ECG lead related to the myocardial area of infarction together with all pathological Q waves.

Negative_regulation (deflection) of QRS associated with infarction

19) Confidence 0.02 Published 2009 Journal Trials Section Body Doc Link PMC2765937 Disease Relevance 0.56 Pain Relevance 0.11

In Electrocardiogram (ECG) there was widespread elevation of the ST segments and a reduction in voltage in QRS complexes.

Negative_regulation (reduction) of QRS

20) Confidence 0.02 Published 2008 Journal Cases J Section Body Doc Link PMC2614946 Disease Relevance 0.98 Pain Relevance 0.10

General Comments

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