INT41125

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Context Info
Confidence 0.38
First Reported 1983
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rb1) enzyme binding (Rb1) DNA binding (Rb1)
cell division (Rb1) transcription factor binding (Rb1)
Rb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 2 94.68 High High
noradrenaline 3 94.00 High High
Clonidine 1 90.56 High High
antagonist 1 77.20 Quite High
Catecholamine 1 70.64 Quite High
fibrosis 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 3 100.00 Very High Very High Very High
Apoptosis 32 79.56 Quite High
Polycystic Kidney Disease 36 77.52 Quite High
Disease 26 71.56 Quite High
Renal Disease 3 58.32 Quite High
Cancer 10 36.56 Quite Low
Cyst 21 26.40 Quite Low
Disease Progression 4 23.80 Low Low
Cystic Kidney Diseases 6 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the beta 2-selective drug, terbutaline, at high concentrations displayed a small enhancement of Rb+-secretion.
Positive_regulation (enhancement) of Localization (secretion) of Rb
1) Confidence 0.38 Published 1983 Journal Acta Physiol. Scand. Section Abstract Doc Link 6136155 Disease Relevance 0 Pain Relevance 0.39
This in turn leads to a cascade of events whereby the mitogen-stimulated, cyclin D-dependent kinases phosphorylate retinoblastoma (Rb) protein, causing release of phosphorylated Rb from the transcription factor family known as E2F, and allowing S-phase specific gene transcription and subsequent progression through the G1/S transition.
Positive_regulation (causing) of Localization (release) of Rb associated with retinoblastoma
2) Confidence 0.02 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.78 Pain Relevance 0

General Comments

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