INT41230

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Context Info
Confidence 0.67
First Reported 1981
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 16
Total Number 20
Disease Relevance 6.37
Pain Relevance 21.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Nrm) nucleus (Nrm)
Anatomy Link Frequency
neurons 6
LRN 2
nucleus 2
neuronal 1
spinal 1
Nrm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Raphe magnus 281 100.00 Very High Very High Very High
Analgesic 38 100.00 Very High Very High Very High
Serotonin 6 100.00 Very High Very High Very High
Dorsal horn 4 100.00 Very High Very High Very High
Glutamate 181 99.98 Very High Very High Very High
Central grey 28 99.90 Very High Very High Very High
Inflammation 5 99.88 Very High Very High Very High
Enkephalin 5 99.82 Very High Very High Very High
Opioid 144 99.76 Very High Very High Very High
Morphine 402 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 31 99.92 Very High Very High Very High
INFLAMMATION 3 99.88 Very High Very High Very High
Pain 115 99.68 Very High Very High Very High
Rheumatoid Arthritis 3 94.96 High High
Nociception 17 93.84 High High
Hyperalgesia 8 71.52 Quite High
Neuropathic Pain 4 70.52 Quite High
Paralysis 1 68.16 Quite High
Cancer 4 64.88 Quite High
Low Back Pain 16 64.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In general, both PBA (ipsi- and contralateral) and NRM CS produced profound inhibition of electrically evoked responses in all neuron types, e.g., responses reduced to mean values of 50-53% of control in LTM neurons, 35-46% in WDR, NS, and S+D neurons, and 61-63% in D neurons.
Gene_expression (produced) of NRM CS in neurons associated with raphe magnus
1) Confidence 0.67 Published 1995 Journal Pain Section Abstract Doc Link 7478709 Disease Relevance 0.23 Pain Relevance 0.67
In a double immunohistochemical labeling experiment, coexpression of the serotonin marker tryptophan hxdroxylase and the alpha4 nAChR subunit in NRM neurons was observed.
Gene_expression (coexpression) of NRM in neurons associated with raphe magnus and serotonin
2) Confidence 0.64 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9651224 Disease Relevance 0 Pain Relevance 0.72
The present study was designed to investigate the source of AVP in the rat NRM during pain process using the methods of nucleus push-pull perfusion and radioimmunoassay.
Spec (investigate) Gene_expression (source) of NRM in nucleus associated with pain and raphe magnus
3) Confidence 0.59 Published 2009 Journal Peptides Section Abstract Doc Link 19520128 Disease Relevance 0.63 Pain Relevance 1.05
Occasionally, facilitation of neuronal activity was also produced by PBA and NRM stimulation. 3.
Gene_expression (produced) of NRM in neuronal associated with raphe magnus
4) Confidence 0.58 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 7931526 Disease Relevance 0.72 Pain Relevance 0.65
Following carrageenan inflammation, the expression of 5-HT2A receptor mRNA in ipsilateral dorsal horn, bilateral NRM, vlPAG and DRN was significantly increased.
Gene_expression (expression) of NRM in DRN associated with raphe magnus, inflammation and dorsal horn
5) Confidence 0.52 Published 2001 Journal Brain Res. Section Abstract Doc Link 11325358 Disease Relevance 0.35 Pain Relevance 0.77
The data suggested that AVP in the PVN might be transferred to the NRM to participate in pain modulation.
Gene_expression (transferred) of NRM in PVN associated with pain and raphe magnus
6) Confidence 0.51 Published 2009 Journal Peptides Section Abstract Doc Link 19520128 Disease Relevance 0.65 Pain Relevance 1.03
The present study tries to determine the effect of morphine-induced analgesia following microinjection into the CnF in the absence of NRM.
Neg (absence) Gene_expression (absence) of NRM associated with raphe magnus, analgesia and morphine
7) Confidence 0.49 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18486337 Disease Relevance 0.09 Pain Relevance 1.29
receptor-expressing NRM cells by glutamate inputs during morphine tolerance (see below).
Gene_expression (expressing) of NRM associated with raphe magnus, glutamate, tolerance and morphine
8) Confidence 0.44 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074357 Disease Relevance 0 Pain Relevance 0.93
These results suggest that the analgesic mechanism of ABT-594 may in part involve the activation of the NRM, a site where alpha4-containing nAChRs are expressed by serotonergic neurons.
Gene_expression (expressed) of NRM in serotonergic neurons associated with raphe magnus and analgesic
9) Confidence 0.43 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9651224 Disease Relevance 0 Pain Relevance 0.64
Immunohistological studies using mAb 299 revealed the expression of alpha4-containing nAChRs in the NRM.
Gene_expression (expression) of NRM associated with raphe magnus
10) Confidence 0.43 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9651224 Disease Relevance 0.06 Pain Relevance 0.82
The highest baseline levels of glutamate (P < 0.0001), aspartate (P < 0.0001), GABA (P < 0.01), taurine (P < 0.0001), and glycine (P < 0.001) were seen in the NRM.
Gene_expression (seen) of NRM associated with raphe magnus, gaba and glutamate
11) Confidence 0.41 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 17940899 Disease Relevance 0.41 Pain Relevance 1.03
receptor-containing NRM neurons.
Gene_expression (neurons) of NRM in neurons associated with raphe magnus
12) Confidence 0.39 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074357 Disease Relevance 0.64 Pain Relevance 2.57
m thick) containing the NRM.
Gene_expression (containing) of NRM associated with raphe magnus
13) Confidence 0.39 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074357 Disease Relevance 0.29 Pain Relevance 0.78
According to their electrophysiological characters and opioid responses, NRM neurons in an in vitro preparation have been divided into two general types, primary cells that lack the ?
Gene_expression (neurons) of NRM in neurons associated with raphe magnus and opioid
14) Confidence 0.39 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074357 Disease Relevance 0.33 Pain Relevance 2.58
In 9 cells, both NE-LRN and GLU-NRM produced a strong inhibition, with the magnitude of effect between the 2 drugs significantly correlated.
Gene_expression (produced) of NRM in LRN associated with raphe magnus and glutamate
15) Confidence 0.20 Published 1993 Journal Pain Section Abstract Doc Link 8309708 Disease Relevance 0 Pain Relevance 0.87
In a second group of cells (n = 12), GLU-NRM produced an inhibitory effect while NE-LRN had no effect on the cells' baseline firing rate.
Gene_expression (produced) of NRM in LRN associated with raphe magnus and glutamate
16) Confidence 0.20 Published 1993 Journal Pain Section Abstract Doc Link 8309708 Disease Relevance 0 Pain Relevance 0.92
Morphine, DADL and EKC produced dose-dependent analgesic effects at the NRPG, NRM, PAG and LSS.
Gene_expression (produced) of NRM in PAG associated with raphe magnus, analgesic, urological neuroanatomy, enkephalin and morphine
17) Confidence 0.17 Published 1983 Journal Life Sci. Section Abstract Doc Link 6141508 Disease Relevance 0.38 Pain Relevance 1.87
The mean intensity of stimulation in the NRM producing an attenuation to 50% of the control 50 degrees C heat-evoked response was significantly lower than the mean intensity of stimulation in the PAG producing a 50% attenuation of the same spinal units.
Gene_expression (producing) of NRM in spinal associated with raphe magnus and central grey
18) Confidence 0.11 Published 1983 Journal J. Neurophysiol. Section Abstract Doc Link 6663336 Disease Relevance 0.82 Pain Relevance 0.87
Furthermore, it was shown that injection of NT into the PAG produced excitation of the NRM neurons.
Gene_expression (excitation) of NRM in neurons associated with raphe magnus and central grey
19) Confidence 0.09 Published 1984 Journal Brain Res. Section Abstract Doc Link 6518391 Disease Relevance 0.53 Pain Relevance 0.97
This suggests that some of the modulatory influences involve endogenous opiate-related mechanisms. (4) Many of the oralis neurons were identified as trigeminothalamic relay neurons on the basis of their antidromic response to ventrobasal thalamic stimulation; PAG and NRM conditioning produced not only a suppression of their orthodromic responses to oral-facial stimuli but also caused a decrease in the antidromic excitability of the relay neurons.
Gene_expression (produced) of NRM in neurons associated with raphe magnus, opiate and central grey
20) Confidence 0.03 Published 1981 Journal Pain Section Abstract Doc Link 6262699 Disease Relevance 0.24 Pain Relevance 0.63

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