INT4146

From wiki-pain
(Difference between revisions)
Jump to: navigation, search
(Generated page)
 

Latest revision as of 05:35, 23 September 2012

Context Info
Confidence 0.47
First Reported 1976
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 49
Total Number 49
Disease Relevance 31.00
Pain Relevance 4.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SHBG)
Anatomy Link Frequency
blood 4
adrenal glands 2
ovaries 2
plasma 1
cleavage 1
SHBG (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 1 99.74 Very High Very High Very High
Pain 49 99.56 Very High Very High Very High
alcohol 11 99.38 Very High Very High Very High
Inflammation 258 99.00 Very High Very High Very High
spinal inflammation 6 98.96 Very High Very High Very High
metalloproteinase 19 98.76 Very High Very High Very High
depression 69 97.36 Very High Very High Very High
Dismenorea 13 97.20 Very High Very High Very High
nMDA receptor 42 95.96 Very High Very High Very High
anesthesia 7 93.68 High High
Disease Link Frequency Relevance Heat
Obesity 547 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 232 100.00 Very High Very High Very High
Metabolic Syndrome 293 99.82 Very High Very High Very High
Pain 61 99.56 Very High Very High Very High
Hyperandrogenism 7 99.48 Very High Very High Very High
Diabetes Mellitus 609 99.44 Very High Very High Very High
Adrenal Cancer 143 99.34 Very High Very High Very High
Primary Sclerosing Cholangitis 1 99.24 Very High Very High Very High
Hypertension 737 99.22 Very High Very High Very High
INFLAMMATION 292 99.00 Very High Very High Very High

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, it was shown recently that two proteins (ABP and GRIP) which interact with the carboxy-terminus of AMPA receptors, bind to the membrane-type 5 matrix metalloproteinase (MT5-MMP), thereby directing MT5-MMP to growth cones and synaptic sites in neurons, where the proteolytic activity of this protein may be involved in remodelling of synapses by cleavage of cadherins and matrix proteins [10].
ABP Binding (bind) of in cleavage associated with metalloproteinase
1) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.45
Testosterone binds strongly to SHBG, and it is therefore largely the free and albumin-bound testosterone that is available for biological action (10).
SHBG Binding (binds) of
2) Confidence 0.42 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 0.21 Pain Relevance 0
Total serum testosterone consists of free testosterone (2%–3%), testosterone bound to sex hormone binding globulin (SHBG) (45%) and testosterone bound to other proteins (mainly albumin ?
SHBG Binding (bound) of
3) Confidence 0.41 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 1.31 Pain Relevance 0.03
Only 1–2% of testosterone circulates free in the blood; the remaining 98–99% is bound to albumin (40–50%) and to sex hormone binding globulin (SHBG) (50–60%).
hormone binding globulin Binding (bound) of in blood
4) Confidence 0.37 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 0.28 Pain Relevance 0
The classical, but not the only approach to measuring bio-T, is to precipitate out SHBG (and hence the testosterone which is strongly bound to it as well) and measure the remainder as total testosterone (Tremblay 2003).
SHBG Binding (bound) of
5) Confidence 0.36 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686330 Disease Relevance 0.22 Pain Relevance 0
Pain catastrophizing also interacted with SBP, DBP and HR reactivity to affect pain such that high catastrophizers who showed low cardiovascular reactivity to the interviews reported the greatest pain.
SBP Binding (interacted) of associated with pain
6) Confidence 0.36 Published 2008 Journal J Behav Med Section Abstract Doc Link 18158618 Disease Relevance 1.54 Pain Relevance 1.55
Total serum testosterone consists of free testosterone (2%–3%), testosterone bound to sex hormone binding globulin (SHBG) (45%) and testosterone bound to other proteins (mainly albumin ?
hormone binding globulin Binding (bound) of
7) Confidence 0.36 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 1.31 Pain Relevance 0.03
From a practical point of view, the diagnosis of HSDD should encompass the major biological causes such as states of sex hormone deficiency, especially low androgens, mood disorders, including anxiety and depression, and many clinical conditions and related medications with a potential impact on women’s sexual function.
sex hormone Binding (deficiency) of associated with depression, affective disorder, anxiety disorder and hypoactive sexual desire disorder
8) Confidence 0.34 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971736 Disease Relevance 1.25 Pain Relevance 0.15
Only 1–2% of testosterone circulates free in the blood; the remaining 98–99% is bound to albumin (40–50%) and to sex hormone binding globulin (SHBG) (50–60%).
SHBG Binding (bound) of in blood
9) Confidence 0.33 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 0.28 Pain Relevance 0
Obesity is also associated with low total testosterone and reduced SHBG levels.
SHBG Binding (associated) of associated with metabolic syndrome
10) Confidence 0.33 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 2.88 Pain Relevance 0
Testosterone bound to SHBG is tightly bound and is biologically inactive.
SHBG Binding (bound) of
11) Confidence 0.32 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 0.79 Pain Relevance 0.03
Serum SHBG
    was significantly and independently associated with serum adiponectin levels among women. 
SHBG Binding (associated) of
12) Confidence 0.31 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.93 Pain Relevance 0.11
Whereas in men
    HDL-cholesterol and CRP were covariates of adiponectin (both p<0.01), SHBG and
    apolipoprotein B positively associated in women (p<0.001), independent of BMI and
    fasting insulin levels.
SHBG Binding (associated) of associated with disorder of lipid metabolism
13) Confidence 0.31 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2491727 Disease Relevance 0.51 Pain Relevance 0.04
Total serum testosterone consists of free testosterone (2%–3%), testosterone bound to sex hormone binding globulin (SHBG) (45%) and testosterone bound to other proteins (mainly albumin ?
SHBG Binding (bound) of
14) Confidence 0.31 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 1.23 Pain Relevance 0.03
The amount of bioavailable testosterone can be measured as a percentage of the total testosterone after precipitation of the SHBG bound fraction using ammonium sulphate.
SHBG Binding (bound) of
15) Confidence 0.31 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 0.20 Pain Relevance 0
If pregnancy is not desired, oral contraceptive pills provide several benefits, including lowering ovarian androgen production, maintaining monthly menses, and raising sex hormone binding globulin (SHBG), which lowers free testosterone and mitigates some of the hyperandrogenism with lower doses of glucocorticoid therapy.
SHBG Binding (mitigates) of associated with hyperandrogenism
16) Confidence 0.31 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2896848 Disease Relevance 0.50 Pain Relevance 0.10
These three novel findings, namely, a threshold effect,
   evidence of a gender difference in anti-inflammatory properties of adiponectin and an
   independent association of low SHBG with moderately low adiponectin levels in women may lead to
   the generation of a hypothesis for women that adiponectin possesses impaired anti-inflammatory
   properties, likely influenced by SHBG levels, while the emergence of an inverse relationship
   between obesity and adiponectin levels is precluded.
SHBG Binding (association) of associated with inflammation and obesity
17) Confidence 0.30 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.03 Pain Relevance 0.14
Inverse association with
   triglycerides and CRP existed in men, in addition to a positive one with testosterone level
   (1.23-fold), but in women, only SHBG was associated [ß-coefficient 2.07,
   p<0.001].


SHBG Binding (associated) of
18) Confidence 0.30 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.76 Pain Relevance 0.03
This is in
    partial agreement with the recent work of Yasui et al. 16 in which serum adiponectin concentrations in postmenopausal women alone were neither
    correlated, nor associated with BMI independently of SHBG but were so among men.
SHBG Binding (associated) of associated with obesity
19) Confidence 0.30 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.71 Pain Relevance 0.06
Binding by plasma sex hormone binding protein and androgen receptors is excluded by saturation with dihydrotestosterone, by transferrin with cortisol, and that of nonspecific binding by means of charcoal-dextran absorption.
sex hormone Binding (Binding) of in plasma
20) Confidence 0.29 Published 1976 Journal Contracept Fertil Sex (Paris) Section Abstract Doc Link 12334585 Disease Relevance 0 Pain Relevance 0.09

[edit] General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox