INT41490

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Context Info
Confidence 0.45
First Reported 1983
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 1.59
Pain Relevance 3.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
neuronal 1
reticular formation 1
muscle 1
skeletal muscle cell 1
Acot1 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 75 99.90 Very High Very High Very High
tetrodotoxin 9 99.82 Very High Very High Very High
opioid receptor 1 99.36 Very High Very High Very High
Neuronal nitric oxide synthase 2 99.18 Very High Very High Very High
Clonidine 14 99.12 Very High Very High Very High
anesthesia 18 95.60 Very High Very High Very High
Neurotransmitter 4 95.04 Very High Very High Very High
Pyramidal cell 61 94.92 High High
Hippocampus 24 92.88 High High
isoflurane 2 91.44 High High
Disease Link Frequency Relevance Heat
Disease 107 99.12 Very High Very High Very High
Sprains And Strains 4 96.44 Very High Very High Very High
Contracture 2 93.48 High High
Parkinson's Disease 2 90.88 High High
Dementia 16 90.20 High High
Neurodegenerative Disease 10 88.56 High High
Proteostasis Deficiencies 1 83.68 Quite High
Targeted Disruption 29 75.00 Quite High
Colitis 3 75.00 Quite High
Cognitive Disorder 9 72.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that clonidine impairs the neuromuscular transmission by a noncompetitive blockade of ACh receptors, most likely affecting the ACh channel but not the recognition site of the ACh receptor.
Regulation (affecting) of ACh receptor associated with clonidine
1) Confidence 0.45 Published 1984 Journal Proc. Natl. Sci. Counc. Repub. China B Section Abstract Doc Link 6152843 Disease Relevance 0.09 Pain Relevance 0.55
Hydroquinone (HQ) reduced relaxation due to a-NaNO2, but did not affect that of EFS and ACh.
Neg (not) Regulation (affect) of ACh
2) Confidence 0.32 Published 1997 Journal Urol. Res. Section Abstract Doc Link 9286036 Disease Relevance 0 Pain Relevance 0.11
In the latter, ACh response was not depressed by clonidine probably because of its inherent anticholinesterase activity.
Regulation (response) of ACh associated with clonidine
3) Confidence 0.24 Published 1984 Journal Proc. Natl. Sci. Counc. Repub. China B Section Abstract Doc Link 6152843 Disease Relevance 0.09 Pain Relevance 0.59
These results show for the first time that NO modulates ACh in the medial pontine reticular formation of the cat via an NO-sensitive sGC signal transduction cascade.
Regulation (modulates) of ACh in reticular formation
4) Confidence 0.23 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16424074 Disease Relevance 0 Pain Relevance 0.43
A/J mice had a higher baseline Rrs, yet the response to ACh was independent of baseline Rrs.
Regulation (response) of ACh
5) Confidence 0.10 Published 1995 Journal J. Appl. Physiol. Section Abstract Doc Link 7592218 Disease Relevance 0 Pain Relevance 0
We have used in vivo microdialysis to investigate the regulation of hippocampal acetylcholine (ACh) levels in mice that are devoid of AChE (AChE-/- mice).
Spec (investigate) Regulation (regulation) of ACh
6) Confidence 0.08 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17212694 Disease Relevance 0.36 Pain Relevance 0.12
Acetylcholine (ACh) is an important regulator of intestinal epithelial ion transport via muscarinic or nicotinic ACh receptors.
Regulation (regulator) of ACh
7) Confidence 0.08 Published 2006 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 17218980 Disease Relevance 0.13 Pain Relevance 0.04
The SCCs are capable of synthesizing and packaging acetylcholine (ACh)
Regulation (capable) of ACh
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.07 Pain Relevance 0.07
The concentration of indomethacin had no effect both on baseline tension and on the ACh- and high K+-induced constrictions of BSMs (data not shown).


Neg (no) Regulation (effect) of ACh
9) Confidence 0.07 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0 Pain Relevance 0
We evaluated the effects of superfusing 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), eNOS null (B) an inhibitor of soluble guanylyl cyclase, and 7-nitroindazole sodium (7-NI), a selective neuronal nitric oxide synthase (nNOS) inhibitor, on the acetylcholine (ACh) response in endothelial NOS (eNOS) null mice.
Regulation (response) of ACh in neuronal associated with neuronal nitric oxide synthase
10) Confidence 0.05 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486242 Disease Relevance 0.07 Pain Relevance 0.14
By contrast, topical superfusion of 7-NI (100 microM) attenuated the ACh response in eNOS mutants only (66%, P < 0.05, and 25% decrease, P < 0.05, at 1 and 10 microM ACh, respectively).
Regulation (response) of ACh
11) Confidence 0.05 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486242 Disease Relevance 0.17 Pain Relevance 0.11
In addition, ketamine can act on other receptors or channels including the GABAa receptor, nicotinic and muscarinc Ach receptors, and opioid receptors, etc [3], [31] which also vary among different cell types.
Regulation (act) of Ach associated with ketamine and opioid receptor
12) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999569 Disease Relevance 0.05 Pain Relevance 0.74
Inhibition of muscle contractions with TTX did not affect the number of AChRs or their distribution.
Neg (not) Regulation (affect) of AChRs in muscle associated with tetrodotoxin
13) Confidence 0.02 Published 1983 Journal Exp. Cell Res. Section Abstract Doc Link 6617773 Disease Relevance 0 Pain Relevance 0.25
We have studied the appearance, distribution and regulation of acetylcholinesterase (AChE) and acetylcholine receptors (AChRs) in a mouse skeletal muscle cell line (C2), that was originally isolated and described by Yaffe & Saxel [54].
Regulation (regulation) of AChRs in skeletal muscle cell
14) Confidence 0.02 Published 1983 Journal Exp. Cell Res. Section Abstract Doc Link 6617773 Disease Relevance 0 Pain Relevance 0.04
ACh can then bind to nicotinic and muscarinergic ACh receptors that are thus also targets for the treatment of AD [29-31].
Regulation (targets) of ACh associated with disease
15) Confidence 0.01 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.54 Pain Relevance 0.15

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