INT41629

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Context Info
Confidence 0.27
First Reported 1982
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.38
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PCSK4)
PCSK4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 11 98.16 Very High Very High Very High
nociceptor 1 25.00 Low Low
cytokine 5 5.44 Low Low
Inflammation 3 5.08 Very Low Very Low Very Low
Lasting pain 3 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Acute pain 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Peripheral nerve injury 1 5.00 Very Low Very Low Very Low
dorsal rhizotomy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 15 98.16 Very High Very High Very High
Nociception 3 57.36 Quite High
Death 1 40.76 Quite Low
Apoptosis 1 36.96 Quite Low
Demyelinating Disease 1 33.92 Quite Low
INFLAMMATION 3 5.08 Very Low Very Low Very Low
Injury 16 5.00 Very Low Very Low Very Low
Nervous System Injury 4 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eliminating effects of stimulus intensity resulted in two PCs (PC2, PC4) which distinguished exclusively between non-pain and pain.
Positive_regulation (resulted) of PC4 associated with pain
1) Confidence 0.27 Published 1982 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 6173204 Disease Relevance 0.32 Pain Relevance 0.35
Several of these up regulated genes are engaged in transcription and translation regulation: transcription factor AP-4, transcriptional coactivator Pc4, Nrf2, EIF5 (Eukaryotic translation initiation factor 5), and PABPL1 (polyadenylate-binding protein 1).
Positive_regulation (engaged) of Pc4
2) Confidence 0.17 Published 2002 Journal BMC Genomics Section Body Doc Link PMC137578 Disease Relevance 0.06 Pain Relevance 0

General Comments

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