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Context Info
Confidence 0.35
First Reported 1982
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.36
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctrc)
Anatomy Link Frequency
pancreas 2
gland 2
Ctrc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 11 99.84 Very High Very High Very High
tetrodotoxin 1 93.28 High High
Chronic pancreatitis 6 90.44 High High
Disease Link Frequency Relevance Heat
Disease Susceptibility 1 97.52 Very High Very High Very High
Disease 1 96.44 Very High Very High Very High
Pancreatitis 7 90.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The recent identification of chymotrypsin C (CTRC) as enzyme Y, which was proposed to protect the pancreas by degrading prematurely activated trypsinogen within the pancreas 20 years ago, made CTRC an excellent candidate gene for disease-association studies.
Positive_regulation (activated) of Protein_catabolism (degrading) of CTRC in pancreas associated with disease
1) Confidence 0.35 Published 2008 Journal Hum. Genet. Section Abstract Doc Link 18172691 Disease Relevance 0.36 Pain Relevance 0.17
The addition of exogenous peptidases such as pronase, chymotrypsin and an extract of black widow spider venom gland dramatically increased the rate of degradation of SP, shortened the fading response and blocked the development of tachyphylaxis.
Positive_regulation (increased) of Protein_catabolism (degradation) of chymotrypsin in gland associated with substance p
2) Confidence 0.02 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6180910 Disease Relevance 0 Pain Relevance 0.52

General Comments

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