INT41729

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Context Info
Confidence 0.43
First Reported 1982
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.70
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLA2G1B) extracellular space (PLA2G1B) extracellular region (PLA2G1B)
Anatomy Link Frequency
endothelial cells 2
PLA2G1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 4 99.80 Very High Very High Very High
dexamethasone 3 93.80 High High
Inflammation 5 89.52 High High
COX2 2 75.00 Quite High
cytokine 4 73.04 Quite High
cINOD 3 69.44 Quite High
Peripheral nervous system 1 62.40 Quite High
ischemia 1 58.96 Quite High
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 4 99.80 Very High Very High Very High
Adult Respiratory Distress Syndrome 28 93.60 High High
Neuropathy 4 92.96 High High
INFLAMMATION 5 89.52 High High
Lung Injury 16 87.64 High High
Neuroblastoma 2 82.60 Quite High
Pressure And Volume Under Development 6 80.88 Quite High
Injury 1 78.08 Quite High
Necrosis 1 77.36 Quite High
Cancer 1 77.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During EAN a marked reduction of phosphatidylinositol, sulfatides and serine-plasmalogen as well as a significant increase of phospholipase A2 activity could be observed.
Negative_regulation (reduction) of Positive_regulation (increase) of phospholipase A2 associated with neuritis
1) Confidence 0.43 Published 1982 Journal Fortschr. Med. Section Abstract Doc Link 6184294 Disease Relevance 0.89 Pain Relevance 0.41
Palmitoyl trifluormethyl ketone, an inhibitor of Ca(2+) independent phospholipase A2 (iPLA2) and a less potent inhibitor of cytosolic PLA2, dose-dependently reduced the IL-1beta induced PGE2 secretion.
Negative_regulation (inhibitor) of Neg (independent) Positive_regulation (independent) of phospholipase A2
2) Confidence 0.19 Published 2001 Journal Exp. Gerontol. Section Abstract Doc Link 11250126 Disease Relevance 0.73 Pain Relevance 0.44
Moreover, in vitro studies have revealed that APC causes a dose-dependent inhibition of interferon-induced expression of phospholipase A2 [45] and upregulation of cyclooxygenase II expression in endothelial cells [46].
Negative_regulation (inhibition) of Positive_regulation (upregulation) of phospholipase A2 in endothelial cells
3) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2646309 Disease Relevance 1.08 Pain Relevance 0.18

General Comments

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