INT42335

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Context Info
Confidence 0.34
First Reported 1981
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 5.98
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSB) mitochondrion (CTSB) extracellular space (CTSB)
extracellular region (CTSB) intracellular (CTSB) lysosome (CTSB)
Anatomy Link Frequency
cleavage 1
CTSB (Homo sapiens)
CTSB - L26V (1)
Pain Link Frequency Relevance Heat
cINOD 11 100.00 Very High Very High Very High
addiction 1 99.44 Very High Very High Very High
substance P 1 98.64 Very High Very High Very High
Chronic pancreatitis 5 98.04 Very High Very High Very High
Central nervous system 1 75.00 Quite High
Paracetamol 2 58.48 Quite High
Abeta 3 56.56 Quite High
Pain 7 50.00 Quite Low
Lasting pain 2 50.00 Quite Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 100.00 Very High Very High Very High
Diabetes Mellitus 266 98.92 Very High Very High Very High
Alzheimer's Dementia 16 98.60 Very High Very High Very High
Pancreatitis 127 98.44 Very High Very High Very High
Disease 19 79.00 Quite High
Calcification 8 77.52 Quite High
Clinical Trials And Case Reports 4 66.08 Quite High
Syndrome 12 65.04 Quite High
Toxicity 1 60.40 Quite High
Pain 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data also suggests that co-existence of TCF7L2 variants and the SPINK1 and CTSB mutations, that predict susceptibility to exocrine damage, may interact to determine the onset of diabetes in TCP patients.



CTSB Binding (interact) of associated with diabetes mellitus and pancreatitis
1) Confidence 0.34 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2529279 Disease Relevance 1.71 Pain Relevance 0
We also investigated the interaction between the TCF7L2 variants and N34S SPINK1 and L26V CTSB mutations, since they are strong predictors of risk for TCP.


CTSB (L26V) Binding (interaction) of associated with pancreatitis
2) Confidence 0.34 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2529279 Disease Relevance 2.07 Pain Relevance 0.08
A high perseverance score on the BHI 2 predicted against VI-MD affirmation among APPs.
APPs Binding (affirmation) of
3) Confidence 0.32 Published 2009 Journal Pain Med Section Body Doc Link 19416443 Disease Relevance 0 Pain Relevance 0
The authors conclude, that trypsinogen and cathepsin B could potentially interact.
cathepsin B Binding (interact) of
4) Confidence 0.32 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.42 Pain Relevance 0.10
Some patient attributes and the referral/treatment situation appear to be important predictors for harboring the sue MD wish, but differ between APPs and CPPs.


APPs Binding (differ) of
5) Confidence 0.10 Published 2008 Journal Pain Med Section Body Doc Link 18657217 Disease Relevance 0 Pain Relevance 0
The enzyme showed properties associated with a cathepsin-B like enzyme: dependence on -SH groups, pH optimum of 6.5, inhibition by leupeptin and a synthetic analog, Boc-D-Phe-Pro-arginal, and cleavage of dipeptidyl arylamides with basic residues adjacent to or penultimate to the chromatographic grouping. 3.
cathepsin-B Binding (associated) of in cleavage associated with addiction
6) Confidence 0.06 Published 1981 Journal Adv. Biochem. Psychopharmacol. Section Abstract Doc Link 6259908 Disease Relevance 0 Pain Relevance 0.14
Although not fully resolved on the molecular level, the mechanism of action of Abeta42-lowering NSAIDs is independent of cyclooxygenase inhibition and most likely involves direct interaction with components of the gamma-secretase complex or its substrates.
gamma-secretase Spec (likely) Binding (interaction) of associated with cinod
7) Confidence 0.05 Published 2006 Journal Neurodegener Dis Section Abstract Doc Link 17047371 Disease Relevance 0.40 Pain Relevance 0.36
The S2 subsite, critical for specificity, is an important exception; this site, like the S2 subsite of cathepsin B, differs from other cysteine proteases in that it can bind both hydrophobic and basic amino acids [2], [53].
cathepsin B Binding (bind) of
8) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2867933 Disease Relevance 0.07 Pain Relevance 0.06
The cruzain S2 subsite, like that of cathepsin B, differs from other cysteine proteases in that it can bind both hydrophobic and basic amino acids [2], [53].
cathepsin B Binding (bind) of
9) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2867933 Disease Relevance 0 Pain Relevance 0
We hypothesize that gamma-secretase activity, as an enzyme that is strictly associated with cellular membranes, is sensitive to alterations of the hydrophobic membrane environment.
gamma-secretase Binding (associated) of
10) Confidence 0.02 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18359496 Disease Relevance 0.61 Pain Relevance 0.18
The number of SPP binding sites was in excess of gamma-secretase binding sites, making it essential to use selective radioligands for evaluation of gamma-secretase binding under these conditions.
gamma-secretase Binding (binding) of
11) Confidence 0.02 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17932033 Disease Relevance 0.15 Pain Relevance 0.08
We found that the SPP enzyme exhibited distinct binding sites for transition state analogs, non-transition state inhibitors, and the nonsteroidal anti-inflammatory drug sulindac sulfide, analogous to those reported previously for gamma-secretase.
gamma-secretase Binding (binding) of associated with inflammation and cinod
12) Confidence 0.01 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17932033 Disease Relevance 0.25 Pain Relevance 0.10
These compounds seem to target the gamma-secretase complex, increasing gamma-secretase-catalyzed production of Abeta42 in vitro.
gamma-secretase Binding (complex) of
13) Confidence 0.01 Published 2005 Journal Nat. Med. Section Abstract Doc Link 15834426 Disease Relevance 0.31 Pain Relevance 0.27

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