INT4241

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2011
Negated 15
Speculated 10
Reported most in Abstract
Documents 87
Total Number 97
Disease Relevance 28.19
Pain Relevance 55.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
blood 3
skin 3
spinal cord 3
colon 3
nerve 3
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 1081 100.00 Very High Very High Very High
substance P 162 100.00 Very High Very High Very High
Neuropeptide 158 100.00 Very High Very High Very High
qutenza 97 100.00 Very High Very High Very High
antagonist 90 100.00 Very High Very High Very High
Pain 51 100.00 Very High Very High Very High
Potency 37 100.00 Very High Very High Very High
Enkephalin 24 100.00 Very High Very High Very High
Somatostatin 23 100.00 Very High Very High Very High
calcitonin gene related peptide 21 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 6 100.00 Very High Very High Very High
Headache 155 99.88 Very High Very High Very High
Pain 35 99.84 Very High Very High Very High
Erectile Dysfunction 3 99.84 Very High Very High Very High
Cancer 74 99.76 Very High Very High Very High
INFLAMMATION 69 99.64 Very High Very High Very High
Natriuresis 6 99.64 Very High Very High Very High
Hyperalgesia 11 99.60 Very High Very High Very High
Thyroid Neoplasm 88 99.58 Very High Very High Very High
Hypercalcemia 49 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine this question, we examined whether sumatriptan modulate the baseline CGRP levels in vivo, under conditions without trigeminovascular system activation.
Spec (whether) Regulation (modulate) of CGRP associated with sumatriptan and calcitonin gene-related peptide
1) Confidence 0.62 Published 2009 Journal J Headache Pain Section Abstract Doc Link 19266171 Disease Relevance 0.18 Pain Relevance 0.87
Involvement of calcitonin gene-related peptide (CGRP) and 5-hydroxytryptamine (5-HT) during migraine attacks has been demonstrated.
Regulation (Involvement) of CGRP associated with migraine and calcitonin gene-related peptide
2) Confidence 0.62 Published 1991 Journal Trends Neurosci. Section Abstract Doc Link 1709530 Disease Relevance 0.68 Pain Relevance 0.80
Involvement of calcitonin gene-related peptide (CGRP) and 5-hydroxytryptamine (5-HT) during migraine attacks has been demonstrated.
Regulation (Involvement) of calcitonin gene-related peptide associated with migraine and calcitonin gene-related peptide
3) Confidence 0.62 Published 1991 Journal Trends Neurosci. Section Abstract Doc Link 1709530 Disease Relevance 0.68 Pain Relevance 0.80
Substance P regulates the vasodilator activity of calcitonin gene-related peptide.
Regulation (regulates) of calcitonin associated with calcitonin gene-related peptide and substance p
4) Confidence 0.62 Published 1988 Journal Nature Section Title Doc Link 2457810 Disease Relevance 0.16 Pain Relevance 0.79
Effects of substance P, neurokinin A and calcitonin gene-related peptide in human skin and their involvement in sensory nerve-mediated responses.
Regulation (Effects) of calcitonin gene-related peptide in skin associated with neuropeptide, calcitonin gene-related peptide and substance p
5) Confidence 0.62 Published 1987 Journal Eur. J. Pharmacol. Section Title Doc Link 2446892 Disease Relevance 0.67 Pain Relevance 0.74
A thiorphan-sensitive mechanism regulates the action of both exogenous and endogenous calcitonin gene-related peptide (CGRP) in the guinea-pig ureter.
Regulation (regulates) of CGRP in ureter associated with qutenza and calcitonin gene-related peptide
6) Confidence 0.61 Published 1994 Journal Regul. Pept. Section Title Doc Link 7524118 Disease Relevance 0 Pain Relevance 0.65
A thiorphan-sensitive mechanism regulates the action of both exogenous and endogenous calcitonin gene-related peptide (CGRP) in the guinea-pig ureter.
Regulation (regulates) of calcitonin gene-related peptide in ureter associated with qutenza and calcitonin gene-related peptide
7) Confidence 0.61 Published 1994 Journal Regul. Pept. Section Title Doc Link 7524118 Disease Relevance 0 Pain Relevance 0.65
Metoprolol (10(-7) M) and theophilline (10(-3) M) did not affect the inotropic effect of hCGRP.
Neg (not) Regulation (affect) of hCGRP
8) Confidence 0.56 Published 1986 Journal Peptides Section Abstract Doc Link 3489930 Disease Relevance 0 Pain Relevance 0.28
Removal of the endothelium did not significantly affect contractile activity in either CGRP- or lidocaine-treated vessels.
Neg (not) Regulation (affect) of CGRP in vessels associated with lidocaine and calcitonin gene-related peptide
9) Confidence 0.54 Published 1996 Journal J Reconstr Microsurg Section Abstract Doc Link 8723835 Disease Relevance 0.15 Pain Relevance 0.71
We studied the effect of cetraxate on human plasma CGRP and substance P in healthy subjects.
Regulation (effect) of CGRP in plasma associated with substance p and calcitonin gene-related peptide
10) Confidence 0.54 Published 2004 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 15099451 Disease Relevance 0.09 Pain Relevance 0.64
Neonatal capsaicin, at the doses employed in this study, destroyed approximately 70% of CGRP- and tachykinin-immunoreactive sensory axons; whereas 6-hydroxydopamine (6-OHDA) at the doses employed resulted in a complete loss of NPY and tyrosine hydroxylase (TH) immunoreactivity without affecting VIP, CGRP, and tachykinins.
Neg (without) Regulation (affecting) of CGRP associated with qutenza and calcitonin gene-related peptide
11) Confidence 0.45 Published 1991 Journal Am. J. Anat. Section Abstract Doc Link 1719791 Disease Relevance 0 Pain Relevance 0.57
Comparison of vascular effects of calcitonin gene-related peptide and lidocaine on human veins.
Regulation (effects) of calcitonin gene-related peptide in veins associated with lidocaine and calcitonin gene-related peptide
12) Confidence 0.45 Published 1996 Journal J Reconstr Microsurg Section Title Doc Link 8723835 Disease Relevance 0.15 Pain Relevance 0.47
Effects of lidocaine and calcitonin gene-related peptide (CGRP) on isolated human radial arteries.
Regulation (Effects) of calcitonin gene-related peptide in radial associated with lidocaine and calcitonin gene-related peptide
13) Confidence 0.45 Published 1993 Journal J Reconstr Microsurg Section Title Doc Link 8301634 Disease Relevance 0.28 Pain Relevance 0.71
Effects of lidocaine and calcitonin gene-related peptide (CGRP) on isolated human radial arteries.
Regulation (Effects) of CGRP in radial associated with lidocaine and calcitonin gene-related peptide
14) Confidence 0.45 Published 1993 Journal J Reconstr Microsurg Section Title Doc Link 8301634 Disease Relevance 0.28 Pain Relevance 0.71
Sumatriptan does not change calcitonin gene-related peptide in the cephalic and extracephalic circulation in healthy volunteers.
Neg (not) Regulation (change) of calcitonin gene-related peptide associated with sumatriptan and calcitonin gene-related peptide
15) Confidence 0.45 Published 2009 Journal J Headache Pain Section Title Doc Link 19266171 Disease Relevance 0.19 Pain Relevance 1.05
This article summarizes data from in vitro and animal studies, as well as clinical trials, on the effect of calcitonin on bone turnover.
Regulation (effect) of Calcitonin
16) Confidence 0.45 Published 2008 Journal BioDrugs Section Abstract Doc Link 18481897 Disease Relevance 0.51 Pain Relevance 0
This article summarizes data from in vitro and animal studies, as well as clinical trials, on the effect of calcitonin on bone turnover.
Regulation (effect) of calcitonin
17) Confidence 0.45 Published 2008 Journal BioDrugs Section Abstract Doc Link 18481897 Disease Relevance 0.51 Pain Relevance 0
To quantitate the effect of calcitonin gene-related peptide on human extracranial vessels, standard pharmacological procedures were used to examine the potency of the peptide as a vasodilator of human facial artery.
Regulation (effect) of calcitonin in vessels associated with potency and calcitonin gene-related peptide
18) Confidence 0.45 Published 1992 Journal Cephalalgia Section Abstract Doc Link 1559259 Disease Relevance 0.69 Pain Relevance 0.84
The effect of human alpha-calcitonin gene-related peptide (CGRP) on epithelial ion transport was investigated in guinea pig distal colon set up in Ussing flux chambers.
Regulation (effect) of CGRP in colon associated with calcitonin gene-related peptide
19) Confidence 0.45 Published 1989 Journal Regul. Pept. Section Abstract Doc Link 2787038 Disease Relevance 0 Pain Relevance 0.27
An immunohistochemical study in the superficial layers of the spinal dorsal horn revealed a marked increase in substance P immunoreactivity versus controls (12% versus 4%), whereas calcitonin gene-related peptide (CGRP) immunoreactivity was unchanged.
Neg (unchanged) Regulation (unchanged) of CGRP in dorsal horn associated with spinal dorsal horn, calcitonin gene-related peptide and substance p
20) Confidence 0.45 Published 2007 Journal Toxicology Section Abstract Doc Link 17418472 Disease Relevance 1.12 Pain Relevance 0.97

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