INT425

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Context Info
Confidence 0.81
First Reported 1975
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 455
Total Number 462
Disease Relevance 189.64
Pain Relevance 144.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PRL) cytosol (PRL) extracellular region (PRL)
Anatomy Link Frequency
pituitary 56
plasma 12
lactotroph 8
anterior pituitary 6
body 4
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 208 99.98 Very High Very High Very High
Migraine 5 99.96 Very High Very High Very High
Dopamine 4889 99.92 Very High Very High Very High
narcan 470 99.92 Very High Very High Very High
Morphine 469 99.92 Very High Very High Very High
antagonist 1518 99.90 Very High Very High Very High
fluoxetine 684 99.84 Very High Very High Very High
Clonidine 86 99.84 Very High Very High Very High
cytokine 85 99.84 Very High Very High Very High
Serotonin 2111 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1905 100.00 Very High Very High Very High
Adenoma 1069 100.00 Very High Very High Very High
Acromegaly 756 100.00 Very High Very High Very High
Prolactinoma 585 100.00 Very High Very High Very High
Gigantism 16 100.00 Very High Very High Very High
Pituitary Cancer 951 99.98 Very High Very High Very High
Headache 151 99.96 Very High Very High Very High
Stress 495 99.92 Very High Very High Very High
Congenital Anomalies 377 99.92 Very High Very High Very High
Galactorrhea 8694 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that PRL secretion in the pregnant patient at term is unresponsive to usual stimuli and that the multiphasic pattern of PRL secretion uniquely found with labor and vaginal delivery may be associated with dopaminergic neuroendocrine processes during human parturition.
Localization (secretion) of PRL
1) Confidence 0.81 Published 1977 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 857677 Disease Relevance 0.09 Pain Relevance 0.19
The results suggest that alpha 2-adrenergic stimulation does not have a significant role in modulating human PRL secretion during sleep.
Localization (secretion) of PRL
2) Confidence 0.81 Published 1991 Journal Clin Neuropharmacol Section Abstract Doc Link 1742750 Disease Relevance 0 Pain Relevance 0.57
In order to ascertain whether there is a relation between opioids and the serotoninergic system in prolactin (PRL) secretion increase, we investigated in seven healthy men (21 to 26 years of age) the effect of naloxone, a specific opioid antagonist, on PRL secretion induced by fenfluramine, a drug that stimulates serotonin release and inhibits its re-uptake.
Localization (secretion) of PRL associated with antagonist, narcan, serotonin and opioid
3) Confidence 0.81 Published 1985 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3987071 Disease Relevance 0 Pain Relevance 0.56
In order to ascertain whether there is a relation between opioids and the serotoninergic system in prolactin (PRL) secretion increase, we investigated in seven healthy men (21 to 26 years of age) the effect of naloxone, a specific opioid antagonist, on PRL secretion induced by fenfluramine, a drug that stimulates serotonin release and inhibits its re-uptake.
Localization (secretion) of PRL associated with antagonist, narcan, serotonin and opioid
4) Confidence 0.81 Published 1985 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3987071 Disease Relevance 0 Pain Relevance 0.43
In order to ascertain whether there is a relation between opioids and the serotoninergic system in prolactin (PRL) secretion increase, we investigated in seven healthy men (21 to 26 years of age) the effect of naloxone, a specific opioid antagonist, on PRL secretion induced by fenfluramine, a drug that stimulates serotonin release and inhibits its re-uptake.
Localization (secretion) of prolactin associated with antagonist, narcan, serotonin and opioid
5) Confidence 0.81 Published 1985 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3987071 Disease Relevance 0 Pain Relevance 0.43
Naloxone reduces the fenfluramine-induced prolactin release in man.
Localization (release) of prolactin associated with narcan
6) Confidence 0.81 Published 1985 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 3987071 Disease Relevance 0 Pain Relevance 0.72
Higher doses of naloxone (30 mg) do not further inhibit the PRL secretion induced by fenfluramine.
Localization (secretion) of PRL associated with narcan
7) Confidence 0.81 Published 1985 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3987071 Disease Relevance 0 Pain Relevance 0.72
We examined the effects of sleep, clonidine (an alpha 2-adrenergic agonist), and their interaction on PRL secretion.
Localization (secretion) of PRL associated with agonist and clonidine
8) Confidence 0.81 Published 1991 Journal Clin Neuropharmacol Section Abstract Doc Link 1742750 Disease Relevance 0 Pain Relevance 0.49
In order to evaluate the interaction between the opiate-like peptidergic pathways and the dopaminergic system in modulating prolactin (PRL) secretion, ten normal volunteers were studied according to a double-blind, cross-over, randomized experimental design.
Localization (secretion) of prolactin associated with opiate
9) Confidence 0.81 Published 1985 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 3935458 Disease Relevance 0.07 Pain Relevance 0.32
This suggests that, in man, opioid peptides are able to influence PRL release after antidopaminergic stimuli.
Localization (release) of PRL associated with opioid
10) Confidence 0.81 Published 1985 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 3935458 Disease Relevance 0.25 Pain Relevance 0.45
In order to evaluate the interaction between the opiate-like peptidergic pathways and the dopaminergic system in modulating prolactin (PRL) secretion, ten normal volunteers were studied according to a double-blind, cross-over, randomized experimental design.
Localization (secretion) of PRL associated with opiate
11) Confidence 0.81 Published 1985 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 3935458 Disease Relevance 0.07 Pain Relevance 0.32
Interactions of sleep and clonidine on daytime prolactin secretion in humans.
Localization (secretion) of prolactin associated with clonidine
12) Confidence 0.81 Published 1991 Journal Clin Neuropharmacol Section Title Doc Link 1742750 Disease Relevance 0 Pain Relevance 0.59
The suppressive roles of adrenergic stimulation and rapid eye movement (REM) sleep on human prolactin (PRL) secretion are controversial.
Localization (secretion) of PRL in eye
13) Confidence 0.81 Published 1991 Journal Clin Neuropharmacol Section Abstract Doc Link 1742750 Disease Relevance 0 Pain Relevance 0.35
The suppressive roles of adrenergic stimulation and rapid eye movement (REM) sleep on human prolactin (PRL) secretion are controversial.
Localization (secretion) of prolactin in eye
14) Confidence 0.81 Published 1991 Journal Clin Neuropharmacol Section Abstract Doc Link 1742750 Disease Relevance 0 Pain Relevance 0.35
Multiphasic prolactin secretion during parturition in human subjects.
Localization (secretion) of prolactin
15) Confidence 0.81 Published 1977 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 857677 Disease Relevance 0.06 Pain Relevance 0.13
Prolactin (PRL) secretion in the periparturitional period in patients undergoing labor and vaginal delivery follows a remarkable multiphasic pattern not found in patients who underwent elective cesarean section without labor.
Localization (secretion) of PRL
16) Confidence 0.81 Published 1977 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 857677 Disease Relevance 0 Pain Relevance 0
Prolactin (PRL) secretion in the periparturitional period in patients undergoing labor and vaginal delivery follows a remarkable multiphasic pattern not found in patients who underwent elective cesarean section without labor.
Localization (secretion) of Prolactin
17) Confidence 0.81 Published 1977 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 857677 Disease Relevance 0 Pain Relevance 0
This multiphasic pattern of PRL secretion is not correlated with changes in serum concentrations of cortisol, progesterone, estradiol, or estrone.
Localization (secretion) of PRL
18) Confidence 0.81 Published 1977 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 857677 Disease Relevance 0.08 Pain Relevance 0.16
It is concluded that PRL secretion in the pregnant patient at term is unresponsive to usual stimuli and that the multiphasic pattern of PRL secretion uniquely found with labor and vaginal delivery may be associated with dopaminergic neuroendocrine processes during human parturition.
Localization (secretion) of PRL
19) Confidence 0.81 Published 1977 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 857677 Disease Relevance 0.10 Pain Relevance 0.20
Thus, it appears that opiate effects on PRL secretion are influenced by the gonadal steroid environment and that estrogens may play a modulating role.
Localization (secretion) of PRL in gonadal associated with opiate
20) Confidence 0.81 Published 1985 Journal Psychoneuroendocrinology Section Abstract Doc Link 4034850 Disease Relevance 0.26 Pain Relevance 0.54

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