INT42928

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Context Info
Confidence 0.03
First Reported 1982
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk, Oxt) extracellular space (Oxt) cytoplasm (Oxt)
Anatomy Link Frequency
brain 4
Penk (Rattus norvegicus)
Oxt (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 5 100.00 Very High Very High Very High
Morphine 5 99.56 Very High Very High Very High
agonist 2 99.24 Very High Very High Very High
opioid receptor 6 99.06 Very High Very High Very High
Opioid 1 91.56 High High
Dopamine 4 79.60 Quite High
narcan 1 73.32 Quite High
opiate 1 72.48 Quite High
Thalamus 2 28.24 Quite Low
mu opioid receptor 4 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine, beta-endorphin and [D-Ala2] Met-enkephalin inhibit oxytocin release by acetylcholine and suckling.
Met-enkephalin Negative_regulation (inhibit) of Localization (release) of oxytocin associated with enkephalin and morphine
1) Confidence 0.03 Published 1982 Journal Peptides Section Title Doc Link 6291011 Disease Relevance 0 Pain Relevance 0.76
It has been known for a number of years that mu-opioid receptor agonists (e.g., morphine, beta-endorphin, and enkephalin) inhibit luteinizing hormone (LH), vasopressin (VP), and oxytocin (OT) release and stimulate prolactin secretion in rodents and primates by an action at the level of the brain.
enkephalin Negative_regulation (inhibit) of Localization (release) of oxytocin in brain associated with agonist, enkephalin, opioid receptor and morphine
2) Confidence 0.00 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15892097 Disease Relevance 0 Pain Relevance 0.41
It has been known for a number of years that mu-opioid receptor agonists (e.g., morphine, beta-endorphin, and enkephalin) inhibit luteinizing hormone (LH), vasopressin (VP), and oxytocin (OT) release and stimulate prolactin secretion in rodents and primates by an action at the level of the brain.
enkephalin Negative_regulation (inhibit) of Localization (release) of OT in brain associated with agonist, enkephalin, opioid receptor and morphine
3) Confidence 0.00 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15892097 Disease Relevance 0 Pain Relevance 0.41

General Comments

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