INT43350

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Context Info
Confidence 0.61
First Reported 1983
Last Reported 1997
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.60
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
intestinal cells 2
jejunum 2
M cells 2
Mln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 2 100.00 Very High Very High Very High
opiate 1 100.00 Very High Very High Very High
agonist 3 99.98 Very High Very High Very High
Serotonin 6 99.12 Very High Very High Very High
tetrodotoxin 6 98.52 Very High Very High Very High
Morphine 9 98.38 Very High Very High Very High
Chronic pancreatitis 4 98.12 Very High Very High Very High
Somatostatin 5 86.48 High High
antagonist 2 85.08 High High
nud 1 73.60 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 4 98.12 Very High Very High Very High
Dyspepsia 1 73.60 Quite High
Pain 1 67.84 Quite High
Steatorrhea 1 66.32 Quite High
Exocrine Pancreatic Insufficiency 1 61.88 Quite High
Abdominal Pain 2 56.56 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 54.00 Quite High
Functional Bowel Disorder 1 50.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of motilin release: studies with ex vivo perfused canine jejunum.
Regulation (Regulation) of Localization (release) of motilin in jejunum
1) Confidence 0.61 Published 1997 Journal Am. J. Physiol. Section Title Doc Link 9038869 Disease Relevance 0 Pain Relevance 0.47
Therefore, a revised model for the regulation of motilin release from M cells of intestinal mucosa can now be proposed.
Regulation (regulation) of Localization (release) of motilin in M cells
2) Confidence 0.61 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038869 Disease Relevance 0 Pain Relevance 0.64
An in vitro model was developed to study the regulation of motilin release from its endocrine-producing cell.
Regulation (regulation) of Localization (release) of motilin
3) Confidence 0.51 Published 1993 Journal Peptides Section Abstract Doc Link 8483799 Disease Relevance 0 Pain Relevance 0.10
The actions of trimebutine [3,4,5-trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutylester] on the gastrointestinal tract are mediated via (i) an agonist effect on peripheral mu, kappa and delta opiate receptors and (ii) release of gastrointestinal peptides such as motilin and modulation of the release of other peptides, including vasoactive intestinal peptide, gastrin and glucagon.
Regulation (effect) of Localization (release) of motilin associated with agonist and opiate
4) Confidence 0.25 Published 1997 Journal J. Int. Med. Res. Section Abstract Doc Link 9364286 Disease Relevance 0.11 Pain Relevance 0.26
Bombesin, morphine, and erythromycin, recognized stimulants for motilin release in vivo, failed to influence the secretion of motilin in vitro.
Neg (failed) Regulation (influence) of Localization (secretion) of motilin associated with morphine
5) Confidence 0.23 Published 1993 Journal Peptides Section Abstract Doc Link 8483799 Disease Relevance 0 Pain Relevance 0.23
Cholinergic regulation of motilin release from isolated canine intestinal cells.
Regulation (regulation) of Localization (release) of motilin in intestinal cells
6) Confidence 0.23 Published 1993 Journal Peptides Section Title Doc Link 8483799 Disease Relevance 0 Pain Relevance 0.18
Evidence for modulation of motilin secretion by pancreatico-biliary juice in health and in chronic pancreatitis.
Regulation (modulation) of Localization (secretion) of motilin associated with chronic pancreatitis
7) Confidence 0.05 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 6311858 Disease Relevance 0.16 Pain Relevance 0.14
In addition, pancreatic enzymes have an influence on the release of some gastrointestinal hormones (i.e., cholecystokinin, motilin, gastric inhibitory polypeptide).
Regulation (influence) of Localization (release) of motilin associated with cholecystokinin
8) Confidence 0.04 Published 1993 Journal Digestion Section Abstract Doc Link 8224568 Disease Relevance 0.28 Pain Relevance 0.22

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