INT43612

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Context Info
Confidence 0.11
First Reported 1983
Last Reported 2010
Negated 5
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.26
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINB1) cytoplasm (SERPINB1)
Anatomy Link Frequency
pituitary 2
neuronal 1
hypothalamus 1
guard cells 1
B cells 1
SERPINB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 130 99.60 Very High Very High Very High
Opioid 5 99.30 Very High Very High Very High
Pyramidal cell 1 98.72 Very High Very High Very High
Morphine 7 95.52 Very High Very High Very High
opioid receptor 4 95.20 Very High Very High Very High
Endogenous opioid 12 94.48 High High
antagonist 13 92.84 High High
Hippocampus 6 89.68 High High
abdominal pain 1 87.52 High High
agonist 2 80.80 Quite High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 138 99.60 Very High Very High Very High
Pancreatitis 5 98.56 Very High Very High Very High
Hemorrhage 130 96.68 Very High Very High Very High
Disease 40 91.88 High High
Injury 201 90.60 High High
Pressure Volume 2 Under Development 20 88.40 High High
Abdominal Pain 1 87.52 High High
Apoptosis 13 83.20 Quite High
Multiple System Atrophy 8 82.84 Quite High
Syndrome 8 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As some serpins also guard cells against the deleterious effects of promiscuous proteolytic activity [23], it is possible that the cytoprotective function is a common feature of intracellular serpin clades and we hypothesize that up-regulation of serpin B1 gene may be protective in MS.
Regulation (regulation) of serpin B1 in guard cells associated with multiple sclerosis
1) Confidence 0.11 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.82 Pain Relevance 0.22
EI values between the neuronal groups underlying the respective dimensions should behave accordingly, being higher between visual elements than between visual and auditory elements.
Regulation (values) of EI in neuronal
2) Confidence 0.04 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
We conclude that serum ELISA-elastase is of much lower clinical value than RIA-elastase for diagnosis of acute pancreatitis.
Regulation (value) of serum ELISA-elastase associated with pancreatitis
3) Confidence 0.03 Published 1997 Journal Clin. Chem. Section Abstract Doc Link 9439452 Disease Relevance 0.59 Pain Relevance 0.09
Using virus-transformed immortalized B cells and human whole genome bioarrays with validation using RT-qPCR, we found that in siblings with MS, genes for CXCL10, serpin B1 and FUT4 were up regulated whereas CDC5L, TNFRSF19 and HLA-DR were down regulated, among others; transcription analysis showed two intersecting clusters of transcriptional factors - the larger, governed by the upregulated transcription factor 2 (TCF2) and the smaller network regulated by the downregulated CDC5L.


Regulation (regulated) of serpin B1 in B cells associated with multiple sclerosis
4) Confidence 0.03 Published 2008 Journal BMC Med Genomics Section Abstract Doc Link PMC2227948 Disease Relevance 0.28 Pain Relevance 0.14
In both collectives, the anti deltaOR immunoreactivity was predominantly localized in pyramidal neurons of layers (L) II/III and V as well as in round and ovoid neurons of L VI.
Regulation (immunoreactivity) of anti deltaOR in ovoid associated with pyramidal cell
5) Confidence 0.02 Published 2000 Journal Forensic Sci. Int. Section Abstract Doc Link 10978658 Disease Relevance 0.07 Pain Relevance 0.54
This may relate to the presence of the enzyme elastase on the surface of RBC membranes, which may activate coagulation factor IX [225,226].
Regulation (presence) of enzyme elastase
6) Confidence 0.01 Published 2010 Journal Crit Care Section Body Doc Link PMC2887168 Disease Relevance 0.96 Pain Relevance 0
There were no changes in the autoantibodies, anti-Ro and anti-La, in any patients with at least one post-treatment measurement; specifically, in subsequent visits, no patient developed new autoantibodies that were not also detected at study entry.
Neg (no) Regulation (changes) of anti-La
7) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779377 Disease Relevance 0.08 Pain Relevance 0
Thus our results, along with other studies on the regulation of gonadotropin levels by opioids, suggest that oral contraceptives alter the level of beta-EI and in turn may regulate the release of gonadotropins.
Regulation (alter) of beta-EI associated with opioid
8) Confidence 0.01 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319907 Disease Relevance 0 Pain Relevance 0.51
In the hypothalamus, NE alone or in presence of EE2 had no significant effect on beta-EI, but 10X dose of NE+ EE2 caused 50 and 76% decrease in beta-EI in acute and chronic study.
Neg (no) Regulation (effect) of beta-EI in hypothalamus
9) Confidence 0.00 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319907 Disease Relevance 0 Pain Relevance 0.17
In acute study (5 days), NE alone did not change beta-EI significantly in pituitary.
Neg (not) Regulation (change) of beta-EI in pituitary
10) Confidence 0.00 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319907 Disease Relevance 0 Pain Relevance 0
In chronic study (7 weeks), 2NE had no significant effect on pituitary beta-EI, however, NE and EE2 together at 10X dose decreased it by 14%.
Neg (no) Regulation (effect) of beta-EI in pituitary
11) Confidence 0.00 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319907 Disease Relevance 0 Pain Relevance 0.05
Moreover, cells expressing c-fos immunoreactivity were significantly more numerous in ciproxifan- or thioperamide-treated rats than in controls, although no colocalization of anti-c-fos and anti-ChAT immunoreactivity was observed.
Neg (no) Regulation (colocalization) of anti-ChAT
12) Confidence 0.00 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12059975 Disease Relevance 0.46 Pain Relevance 0.49

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