INT43900

Context Info Confidence 0.58 First Reported 1984 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 13 Total Number 14 Disease Relevance 12.00 Pain Relevance 2.03

cytosol (RASA1) signal transduction (RASA1) plasma membrane (RASA1) embryo development (RASA1) cytoplasm (RASA1)

Anatomy Link Frequency tendon 1 RASA1 (Homo sapiens)

Pain Link Frequency Relevance Heat cva 28 99.64 Trigeminal neuralgia 6 98.24 Inflammation 40 98.16 headache 11 98.12 drug abuse 285 97.04 cannabis 80 95.96 cocaine 140 95.20 Pain 19 95.20 cytokine 12 94.40 diclofenac 1 88.08

Disease Link Frequency Relevance Heat Periodontitis 50 100.00 Arterial-venous Cerebral Malformations 17 100.00 Cv General 4 Under Development 11 99.64 Post-traumatic Stress Disorder 532 99.60 Brain Injury 335 99.24 Apoptosis 96 99.04 Convulsion 12 98.52 Neuralgia 6 98.24 INFLAMMATION 46 98.16 Headache 12 98.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Palpation showed the right calf to be soft; a distinct gap was found in the middle third of the Achilles tendon.

Gene_expression (found) of gap in tendon

1) Confidence 0.58 Published 2008 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 18236349 Disease Relevance 0.38 Pain Relevance 0.13

Air contrast CT cisternography is one of the safety and convenient methods to detect the AVM and other vascular anormalies resulting in trigeminal neuralgia.

Gene_expression (detect) of AVM associated with trigeminal neuralgia and arterial-venous cerebral malformations

2) Confidence 0.52 Published 1984 Journal No To Shinkei Section Abstract Doc Link 6335663 Disease Relevance 1.99 Pain Relevance 0.79

Overlap Between Gap in Memory

Gene_expression (Overlap) of Gap

3) Confidence 0.12 Published 2010 Journal Psychol Inj Law Section Body Doc Link PMC2948674 Disease Relevance 1.49 Pain Relevance 0

Diagnosing a Gap in Memory

Gene_expression (Diagnosing) of Gap

4) Confidence 0.10 Published 2010 Journal Psychol Inj Law Section Body Doc Link PMC2948674 Disease Relevance 1.35 Pain Relevance 0

The GaP study has two stages:

Gene_expression (study) of GaP

5) Confidence 0.09 Published 2006 Journal BMC Health Serv Res Section Body Doc Link PMC1513223 Disease Relevance 0.60 Pain Relevance 0

The microsurgical technique used consisted of retrograde dissection of the AVM from the venous side in most cases.

Gene_expression (dissection) of AVM

6) Confidence 0.08 Published 2009 Journal Journal of neurosurgery. Spine Section Body Doc Link 19442003 Disease Relevance 0 Pain Relevance 0

Groups defined by global transcriptional profiles: selection and GAP criteria

Gene_expression (criteria) of GAP

7) Confidence 0.08 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.10 Pain Relevance 0.05

90%) had GAP scores ?

Gene_expression (scores) of GAP

8) Confidence 0.08 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.41 Pain Relevance 0.16

The probability of decreased or increased expression were selected as GAP ?

Gene_expression (selected) of GAP

9) Confidence 0.08 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.20 Pain Relevance 0.20

The higher frequency of Bcl-2 positivity in our GAP group indicates that delayed apoptosis can lead to inflammatory cells staying locally in periodontal tissues longer and thus secreting excessive cytokines, finally to progressive periodontal destruction.

Gene_expression (group) of GAP associated with periodontitis, inflammation, apoptosis and cytokine

10) Confidence 0.08 Published 2006 Journal Head Face Med Section Body Doc Link PMC1524725 Disease Relevance 1.85 Pain Relevance 0.20

Transcripts for which one (or more) GAP was ?

Gene_expression (was) of GAP

11) Confidence 0.07 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.09 Pain Relevance 0.04

Groups defined by toxicology: selection and GAP criteria

Gene_expression (criteria) of GAP

12) Confidence 0.07 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.16 Pain Relevance 0.16

The aim of the present study was to investigate the clinical features and known indicators of apoptosis (p53, Bcl-2, Caspase-3) in patients with generalized aggressive periodontitis (GAP) Methods

Gene_expression (aggressive) of GAP associated with periodontitis and apoptosis

13) Confidence 0.07 Published 2006 Journal Head Face Med Section Abstract Doc Link PMC1524725 Disease Relevance 1.25 Pain Relevance 0.09

Patients with an AVM present with an SAH, neurological deficits, seizures, headaches or may be completely asymptomatic.

Gene_expression (present) of AVM associated with convulsion, headache, cva and arterial-venous cerebral malformations

14) Confidence 0.01 Published 2010 Journal Anesthesiology Research and Practice Section Body Doc Link PMC2911602 Disease Relevance 2.15 Pain Relevance 0.21

General Comments

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