INT44066

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Context Info
Confidence 0.77
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 20
Total Number 26
Disease Relevance 15.09
Pain Relevance 4.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ltf) transport (Ltf) extracellular region (Ltf)
cytoplasm (Ltf)
Anatomy Link Frequency
tears 4
bowel 2
blood 2
leukocytes 2
plasma 1
Ltf (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 15 100.00 Very High Very High Very High
Inflammation 61 99.16 Very High Very High Very High
spastic colon 7 98.24 Very High Very High Very High
Bile 1 97.16 Very High Very High Very High
Chronic pancreatitis 14 95.60 Very High Very High Very High
Arthritis 3 95.28 Very High Very High Very High
Pain 6 95.16 Very High Very High Very High
cINOD 8 94.92 High High
algogenic 1 90.80 High High
tolerance 12 90.40 High High
Disease Link Frequency Relevance Heat
Corneal Disease 420 99.84 Very High Very High Very High
Disorders Of The Lacrimal System 33 99.68 Very High Very High Very High
Disease 159 99.44 Very High Very High Very High
Apoptosis 37 98.76 Very High Very High Very High
INFLAMMATION 76 98.60 Very High Very High Very High
Inflammatory Bowel Disease 14 98.60 Very High Very High Very High
Functional Bowel Disorder 7 98.24 Very High Very High Very High
Hypoxia 3 98.22 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

4 98.20 Very High Very High Very High
Stress 20 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: Lactoferrin is a glycoprotein expressed by activated neutrophils.
Gene_expression (expressed) of Lactoferrin in neutrophils
1) Confidence 0.77 Published 2003 Journal Am. J. Gastroenterol. Section Abstract Doc Link 12818275 Disease Relevance 0.07 Pain Relevance 0.17
Lactoferrin (LF) is a multifunctional protein that is widely found in milk, blood, and other biological fluids.
Gene_expression (found) of LF in blood
2) Confidence 0.60 Published 2006 Journal Brain Res. Section Abstract Doc Link 16380099 Disease Relevance 0.09 Pain Relevance 0.79
Lactoferrin (LF) is a multifunctional protein that is widely found in milk, blood, and other biological fluids.
Gene_expression (found) of Lactoferrin in blood
3) Confidence 0.60 Published 2006 Journal Brain Res. Section Abstract Doc Link 16380099 Disease Relevance 0.09 Pain Relevance 0.79
Lactoferrin is present in pancreatic juice, and greatly increased concentrations are found in the pancreatic juice of patients with chronic pancreatitis.
Gene_expression (present) of Lactoferrin associated with chronic pancreatitis
4) Confidence 0.46 Published 1983 Journal Digestion Section Abstract Doc Link 6653928 Disease Relevance 0.49 Pain Relevance 0.25
2-glycoprotein, and lactoferrin are under-expressed in the tears of patients diagnosed with bilateral KC compared with healthy subjects.
Gene_expression (expressed) of lactoferrin in tears associated with corneal disease
5) Confidence 0.42 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965569 Disease Relevance 0.51 Pain Relevance 0.10
The viscosity, trypsin activity, protein concentration and lactoferrin concentration in selectively aspirated, pure pancreatic secretion uncontaminated by bile, were determined in 46 patients with chronic pancreatitis and compared with the values obtained in 39 control subjects.
Gene_expression (concentration) of lactoferrin in bile associated with bile and chronic pancreatitis
6) Confidence 0.36 Published 1981 Journal Hepatogastroenterology Section Abstract Doc Link 7250899 Disease Relevance 0.24 Pain Relevance 0.29
We have previously shown that intra-articular injection of human lactoferrin (hLf), a glycoprotein that possesses anti-inflammatory and antimicrobial activities, into mice with collagen-induced arthritis reduces inflammation.
Gene_expression (injection) of lactoferrin in articular associated with inflammation and arthritis
7) Confidence 0.35 Published 2001 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 11395926 Disease Relevance 0.83 Pain Relevance 0.42
Diagnostic performance of rapid tests for detection of fecal calprotectin and lactoferrin and their ability to discriminate inflammatory from irritable bowel syndrome.
Gene_expression (detection) of lactoferrin in bowel associated with inflammation and spastic colon
8) Confidence 0.35 Published 2008 Journal Clin. Chem. Lab. Med. Section Title Doc Link 18597588 Disease Relevance 0.66 Pain Relevance 0.36
We validated the diagnostic performance of two new fecal rapid tests (FRTs) for the detection of calprotectin and lactoferrin and assessed their potential to differentiate IBD from irritable bowel syndrome (IBS).
Gene_expression (detection) of lactoferrin in bowel associated with inflammatory bowel disease and spastic colon
9) Confidence 0.35 Published 2008 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 18597588 Disease Relevance 0.78 Pain Relevance 0.30
2-glycoprotein (ZAG; Figure 3), and lactoferrin and quantitative difference more expressed in KC patients was identified as ZAG.


Gene_expression (expressed) of lactoferrin associated with corneal disease
10) Confidence 0.32 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965569 Disease Relevance 0.90 Pain Relevance 0
Lactoferrin is present in normal tears of humans and was found to be invariant through age and independent of sex.
Gene_expression (present) of Lactoferrin in tears
11) Confidence 0.32 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965569 Disease Relevance 1.11 Pain Relevance 0.04
Tear lactoferrin is an 82 kDa protein produced in the acinar cells of the lacrimal gland.
Gene_expression (produced) of lactoferrin in lacrimal gland associated with disorders of the lacrimal system
12) Confidence 0.32 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965569 Disease Relevance 1.11 Pain Relevance 0.04
Founded differences in ZAG, lactoferrin, and IGKC expression were subsequently validated by western blot.


Gene_expression (expression) of lactoferrin
13) Confidence 0.32 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2965569 Disease Relevance 0.37 Pain Relevance 0
IGKC protein, ZAG, and lactoferrin are under-expressed in the tears of patients diagnosed with bilateral KC compared with healthy subjects.
Gene_expression (expressed) of lactoferrin in tears associated with corneal disease
14) Confidence 0.32 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2965569 Disease Relevance 0.36 Pain Relevance 0
RESULTS: Capsaicin-sensitive nerve stimulation produced increases in symptom scores and lactoferrin levels which were similar among the three groups of subjects.
Gene_expression (produced) of lactoferrin in nerve
15) Confidence 0.27 Published 1998 Journal Clin. Exp. Allergy Section Body Doc Link 9537786 Disease Relevance 0.14 Pain Relevance 0
METHODS: The calprotectin and lactoferrin FRTs and ELISA tests were performed on the fecal samples of 114 patients referred for endoscopy, 80% of whom had IBS and 20% IBD, and validated against the endoscopic diagnosis.
Gene_expression (performed) of lactoferrin
16) Confidence 0.26 Published 2008 Journal Clin. Chem. Lab. Med. Section Body Doc Link 18597588 Disease Relevance 0.19 Pain Relevance 0
METHODS: The authors compared the mean values of Schirmer's test, tear osmolarity, tear lysozyme (turbidimetric assay), and tear lactoferrin (radial immunodiffusion) before and after topical anesthesia in the following groups: 56 normal subjects (group 1), 62 blepharitis patients (group 2), and 15 patients with blepharitis-associated dry eye syndrome (group 3).
Gene_expression (values) of lactoferrin in eye
17) Confidence 0.22 Published 1997 Journal Ocul. Immunol. Inflamm. Section Body Doc Link 9145691 Disease Relevance 0.19 Pain Relevance 0
Shear stress, hypoxia and stasis activate the marginated leukocytes to shed L-selectin from their surface and express integrins, matrix metalloproteinase 9, elastase, lactoferrin and free radicals.
Gene_expression (express) of lactoferrin in leukocytes associated with stress, hypoxia and metalloproteinase
18) Confidence 0.17 Published 2007 Journal Clin. Hemorheol. Microcirc. Section Abstract Doc Link 17726258 Disease Relevance 1.08 Pain Relevance 0.59
The nasal lavage fluid (NAL) was assayed for concentration of total protein, albumin, lactoferrin, and number of leukocytes, following by differential count.
Gene_expression (concentration) of lactoferrin in leukocytes
19) Confidence 0.15 Published 1999 Journal Allergy Section Body Doc Link 10485383 Disease Relevance 0.09 Pain Relevance 0
By comparing the global protein expression in tears, we found three spots whose expression was greater in the healthy subjects (IGKC protein, ZAG, and lactoferrin) and one spot was found to be more expressed in KC patients (ZAG).
Gene_expression (expressed) of lactoferrin in tears associated with corneal disease
20) Confidence 0.14 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965569 Disease Relevance 0.58 Pain Relevance 0

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