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Context Info
Confidence 0.35
First Reported 1984
Last Reported 2011
Negated 1
Speculated 2
Reported most in Abstract
Documents 10
Total Number 16
Disease Relevance 8.83
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD209) cell adhesion (CD209) plasma membrane (CD209)
intracellular (CD209) cytoplasm (CD209)
Anatomy Link Frequency
dendritic cells 4
CD209 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 23 94.56 High High
Pain 2 85.76 High High
Inflammatory response 10 84.64 Quite High
cytokine 80 82.72 Quite High
endometriosis 12 62.24 Quite High
tolerance 3 48.48 Quite Low
cva 15 40.08 Quite Low
abdominal pain 10 32.96 Quite Low
headache 10 29.28 Quite Low
psoriasis 2 5.80 Low Low
Disease Link Frequency Relevance Heat
Infection 478 100.00 Very High Very High Very High
Dengue 330 100.00 Very High Very High Very High
Cold Sores 15 99.70 Very High Very High Very High
Adult Respiratory Distress Syndrome 4 99.22 Very High Very High Very High
Disease 43 98.70 Very High Very High Very High
Dengue Hemorrhagic Fever 240 97.80 Very High Very High Very High
Flavivirus Infection 21 96.72 Very High Very High Very High
Low Back Pain 23 94.56 High High
Graft Vs Host Disease 6 94.48 High High
Viral Meningitis 6 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No association of CD209 ?
CD209 Neg (No) Binding (association) of
1) Confidence 0.35 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 1.24 Pain Relevance 0
The C-type lectin DC-SIGN (CD209) is known to be the major dengue receptor on human dendritic cells, and a single nucleotide polymorphism (SNP) in the promoter region of CD209 (?
CD209 Binding (lectin) of in dendritic cells associated with dengue
2) Confidence 0.35 Published 2011 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC3014977 Disease Relevance 0.51 Pain Relevance 0
The C-type lectin DC-SIGN (CD209) is known to be the major dengue receptor on human dendritic cells, and a single nucleotide polymorphism (SNP) in the promoter region of CD209 (?
DC-SIGN Binding (lectin) of in dendritic cells associated with dengue
3) Confidence 0.35 Published 2011 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC3014977 Disease Relevance 0.51 Pain Relevance 0
The C-type lectin DC-SIGN (CD209) is known to be the major dengue receptor on human dendritic cells, and a single nucleotide polymorphism (SNP) in the promoter region of CD209 (?
DC-SIGN Binding (receptor) of in dendritic cells associated with dengue
4) Confidence 0.35 Published 2011 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC3014977 Disease Relevance 0.53 Pain Relevance 0
The C-type lectin DC-SIGN (CD209) is known to be the major dengue receptor on human dendritic cells, and a single nucleotide polymorphism (SNP) in the promoter region of CD209 (?
CD209 Binding (receptor) of in dendritic cells associated with dengue
5) Confidence 0.35 Published 2011 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC3014977 Disease Relevance 0.53 Pain Relevance 0
This study demonstrated that HSV-1 and -2 both interact with the DC-specific C-type lectin DC-SIGN.
DC-SIGN Binding (interact) of associated with cold sores
6) Confidence 0.24 Published 2008 Journal J. Gen. Virol. Section Abstract Doc Link 18796707 Disease Relevance 1.74 Pain Relevance 0.08
The anti-DC-SIGN antibodies that blocked DV infection of IL-4 treated MDMØ to the greatest degree (DC28 and 120612) are known to cross react with DC-SIGNR.
anti-DC-SIGN Binding (cross) of associated with infection
7) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.57 Pain Relevance 0
Differences in glycosylation between DV serotypes, and more broadly between different flaviviruses, may be relevant for interaction with lectin receptors such as MR and DC-SIGN.
DC-SIGN Binding (interaction) of
8) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.34 Pain Relevance 0.04
Even though DV binding to DC-SIGN on these cells is important for attachment, DC-SIGN-mediated viral endocytosis is not required for DV entry [9].
DC-SIGN Binding (binding) of
9) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.43 Pain Relevance 0
Finally, the Fc portions of bound Ab molecules as well as bound C molecules may interact with effector cells with specific receptors for these factors and thereby facilitate viral destruction.
molecules Binding (bound) of
10) Confidence 0.01 Published 1984 Journal J. Invest. Dermatol. Section Abstract Doc Link 6376646 Disease Relevance 0.13 Pain Relevance 0
Finally, the Fc portions of bound Ab molecules as well as bound C molecules may interact with effector cells with specific receptors for these factors and thereby facilitate viral destruction.
molecules Binding (bound) of
11) Confidence 0.01 Published 1984 Journal J. Invest. Dermatol. Section Abstract Doc Link 6376646 Disease Relevance 0.13 Pain Relevance 0
Ab and C molecules deposited on the surfaces of viruses may physically interfere with the ability of the virus to infect a potentially susceptible cell.
molecules Binding (interfere) of
12) Confidence 0.01 Published 1984 Journal J. Invest. Dermatol. Section Abstract Doc Link 6376646 Disease Relevance 0.16 Pain Relevance 0
Effector cells may also interact with Ab and/or C molecules deposited on virus-infected cells, leading to cytotoxic reactions and/or ingestion depending on the type of effector cell involved.
molecules Binding (interact) of
13) Confidence 0.01 Published 1984 Journal J. Invest. Dermatol. Section Abstract Doc Link 6376646 Disease Relevance 0.37 Pain Relevance 0.08
Finally, the Fc portions of bound Ab molecules as well as bound C molecules may interact with effector cells with specific receptors for these factors and thereby facilitate viral destruction.
molecules Binding (interact) of
14) Confidence 0.01 Published 1984 Journal J. Invest. Dermatol. Section Abstract Doc Link 6376646 Disease Relevance 0.13 Pain Relevance 0
The time course suggests that ARDS in this case might have resulted from aggregation of Tg molecules in the pulmonary microcirculation.
molecules Spec (might) Binding (aggregation) of associated with adult respiratory distress syndrome
15) Confidence 0.00 Published 2000 Journal Br J Radiol Section Abstract Doc Link 10884754 Disease Relevance 0.76 Pain Relevance 0.09
One might argue that the apparent effect of KIR2DS5 in other diseases might be caused by its LD with other KIR2D genes whose products bind HLA-C molecules, distinguishing between C1 and C2 epitopes [1], [2].
molecules Spec (might) Binding (bind) of associated with disease
16) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928722 Disease Relevance 0.75 Pain Relevance 0.40

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