INT44612

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Context Info
Confidence 0.67
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 5.73
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (APOE) aging (APOE) Golgi apparatus (APOE)
lipid metabolic process (APOE) cytoplasm (APOE) lipid binding (APOE)
Anatomy Link Frequency
plasma 6
groove 2
epithelium 2
neuronal 1
optic nerve head 1
APOE (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 1 100.00 Very High Very High Very High
Inflammation 21 99.52 Very High Very High Very High
Pain 5 96.32 Very High Very High Very High
Thalamus 1 95.60 Very High Very High Very High
Hippocampus 1 94.76 High High
cINOD 2 90.96 High High
glial activation 2 89.40 High High
abdominal pain 1 87.44 High High
alcohol 3 54.80 Quite High
anesthesia 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 58 100.00 Very High Very High Very High
Alzheimer's Dementia 2 100.00 Very High Very High Very High
Obesity 77 99.78 Very High Very High Very High
Nervous System Injury 22 99.56 Very High Very High Very High
Ganglion Cysts 69 96.88 Very High Very High Very High
Frailty 9 96.88 Very High Very High Very High
Low Back Pain 5 96.60 Very High Very High Very High
Glaucoma 273 94.88 High High
INFLAMMATION 15 92.88 High High
Apoptosis 55 92.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is already known that the LBD of liganded TR binds a single LxxLL motif of a coactivator through the hydrophobic groove of the liganded-LBD [Nolte et al., 1998], with the enhanced activation suggesting a conformational change in NCoA6(NRC) leading to enhanced AD2 activity.
Positive_regulation (leading) of AD2 in groove
1) Confidence 0.67 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Figure 5 shows that a similar effect is also clearly observed in adipocytes, since an increase of 100 to 500% in the amount of apoE is measured in the culture medium at 6 hours, dependent upon the dose of apoA-I used (from 5 to 20 ?
Positive_regulation (increase) of apoE in adipocytes associated with obesity
2) Confidence 0.66 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.31 Pain Relevance 0
SUMMARY OF BACKGROUND DATA: A twofold to fivefold increase in human plasma apolipoprotein E may be a physiologic response to PND as a 250-fold local increase in apolipoprotein E was reported in experimental PND studies in mammals.
Positive_regulation (increase) of apolipoprotein E in plasma
3) Confidence 0.60 Published 1995 Journal Spine Section Body Doc Link 7604328 Disease Relevance 0.18 Pain Relevance 0
SUMMARY OF BACKGROUND DATA: A twofold to fivefold increase in human plasma apolipoprotein E may be a physiologic response to PND as a 250-fold local increase in apolipoprotein E was reported in experimental PND studies in mammals.
Positive_regulation (increase) of apolipoprotein E in plasma
4) Confidence 0.60 Published 1995 Journal Spine Section Body Doc Link 7604328 Disease Relevance 0.17 Pain Relevance 0
STUDY DESIGN: This two-dimensional gel electrophoretic study analyzed the plasma of six groups of patients to determine the association of an elevated apolipoprotein E variant with peripheral nerve damage (PND).
Positive_regulation (elevated) of apolipoprotein E in plasma associated with nervous system injury and disorder of lipid metabolism
5) Confidence 0.60 Published 1995 Journal Spine Section Abstract Doc Link 7604328 Disease Relevance 0.42 Pain Relevance 0.07
As opposed to AD1, the AD2 region has now been shown to be necessary for transcriptional activation by NRs [Mahajan et al., 2007].
Positive_regulation (necessary) of AD2
6) Confidence 0.49 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
This neuronal loss is accompanied by punctate deposits of material that are immunoreactive for amyloid precursor protein, beta-amyloid peptide (Abeta), and apolipoprotein E.
Positive_regulation (immunoreactive) of apolipoprotein E in neuronal associated with alzheimer's dementia, disorder of lipid metabolism and abeta
7) Confidence 0.49 Published 2003 Journal Glia Section Abstract Doc Link 12951652 Disease Relevance 1.06 Pain Relevance 0.39
When classifying ApoE genotypes into absence of ApoE ?
Positive_regulation (absence) of ApoE
8) Confidence 0.47 Published 2006 Journal Osteoporos Int Section Body Doc Link PMC1820757 Disease Relevance 0.65 Pain Relevance 0.03
It is already known that the LBD of liganded TR binds a single LxxLL motif of a coactivator through the hydrophobic groove of the liganded-LBD [Nolte et al., 1998], with the enhanced activation suggesting a conformational change in NCoA6(NRC) leading to enhanced AD2 activity.
Positive_regulation (enhanced) of AD2 in groove
9) Confidence 0.45 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
There was an upregulation of neuroprotective genes, including apolipoprotein E (APOE), cellular retinol binding protein 1 (RBP1), and pigment epithelium derived factor (PEDF/SERPINF1).
Positive_regulation (upregulation) of APOE in epithelium associated with disorder of lipid metabolism
10) Confidence 0.44 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.39 Pain Relevance 0
There was an upregulation of neuroprotective genes, including apolipoprotein E (APOE), cellular retinol binding protein 1 (RBP1), and pigment epithelium derived factor (PEDF/SERPINF1).
Positive_regulation (upregulation) of apolipoprotein E in epithelium associated with disorder of lipid metabolism
11) Confidence 0.44 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.39 Pain Relevance 0
CAPG, GPNMB, RBP1, APOE and TIMP1 were significantly upregulated in astrocytes from glaucomatous donors, consistent with their upregulation in the tissues of the macaque optic nerve head with ExpG.
Positive_regulation (upregulated) of APOE in optic nerve head associated with glaucoma
12) Confidence 0.44 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.47 Pain Relevance 0
RESULTS: A statistically significant (P < 0.005) elevation of the plasma apolipoprotein E variant was found in patients with chronic lumbar pain.
Positive_regulation (elevation) of apolipoprotein E in plasma
13) Confidence 0.40 Published 1995 Journal Spine Section Body Doc Link 7604328 Disease Relevance 0.14 Pain Relevance 0
Preliminary study of an increase of a plasma apolipoprotein E variant associated with peripheral nerve damage.
Positive_regulation (increase) of apolipoprotein E in plasma associated with nervous system injury, inflammation and disorder of lipid metabolism
14) Confidence 0.40 Published 1995 Journal Spine Section Title Doc Link 7604328 Disease Relevance 0.30 Pain Relevance 0.15
Decreased levels of high- and low-density lipoprotein cholesterol and apolipoproteins A-I and A-II and increased levels of plasma triglycerides and apolipoprotein E were found.
Positive_regulation (increased) of apolipoprotein E in plasma associated with disorder of lipid metabolism
15) Confidence 0.26 Published 1984 Journal Am. J. Med. Section Abstract Doc Link 6475985 Disease Relevance 0.88 Pain Relevance 0.09
The frequency of subjects with at least one APOE ?
Positive_regulation (least) of APOE
16) Confidence 0.25 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1420275 Disease Relevance 0.36 Pain Relevance 0

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