INT44889

Context Info Confidence 0.23 First Reported 1983 Last Reported 1983 Negated 1 Speculated 0 Reported most in Abstract Documents 2 Total Number 3 Disease Relevance 0.35 Pain Relevance 0.13

cytosol (EIF2S1) RNA binding (EIF2S1) nucleus (EIF2S1) translation (EIF2S1) cytoplasm (EIF2S1)

Anatomy Link Frequency Eukaryotic cell 1 EIF2S1 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 3 68.96

Disease Link Frequency Relevance Heat Ehrlich Tumor Carcinoma 3 75.00 Pain 3 68.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Eukaryotic cell polypeptide chain initiation factor eIF-2 forms ternary complexes with GTP and initiator Met-tRNAf.

eIF-2 Binding (complexes) of in Eukaryotic cell

1) Confidence 0.23 Published 1983 Journal Biochemistry Section Abstract Doc Link 6551177 Disease Relevance 0.07 Pain Relevance 0

If eIF-2 X GDP is actually the complex released, then GEF is absolutely required for eIF-2 to cycle and it is therefore a new eukaryotic initiation factor.

eIF-2 Binding (complex) of

2) Confidence 0.13 Published 1983 Journal J. Biol. Chem. Section Abstract Doc Link 6553052 Disease Relevance 0.13 Pain Relevance 0.06

Purified GEF increased the rate of exchange of [32P] GDP for unlabeled GDP 25-fold but did not function with phosphorylated eIF-2 (alpha subunit).

eIF-2 Neg (not) Binding (function) of

3) Confidence 0.11 Published 1983 Journal J. Biol. Chem. Section Abstract Doc Link 6553052 Disease Relevance 0.14 Pain Relevance 0.07

General Comments

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