INT44954

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Context Info
Confidence 0.78
First Reported 1981
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 191
Total Number 192
Disease Relevance 105.86
Pain Relevance 23.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
cleavage 19
plaques 7
neuronal 6
brains 4
cerebral cortex 3
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 229 100.00 Very High Very High Very High
Abeta 213 100.00 Very High Very High Very High
cytokine 126 99.82 Very High Very High Very High
Inflammation 505 99.80 Very High Very High Very High
Clonidine 116 99.80 Very High Very High Very High
Neuropeptide 42 99.76 Very High Very High Very High
Catecholamine 2 99.76 Very High Very High Very High
noradrenaline 179 99.58 Very High Very High Very High
excitatory amino acid 7 99.56 Very High Very High Very High
cINOD 501 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 4450 100.00 Very High Very High Very High
Alzheimer's Dementia 2312 100.00 Very High Very High Very High
Targeted Disruption 644 100.00 Very High Very High Very High
Coronary Artery Disease 62 100.00 Very High Very High Very High
Apoptosis 490 99.96 Very High Very High Very High
Cognitive Disorder 692 99.92 Very High Very High Very High
INFLAMMATION 602 99.80 Very High Very High Very High
Lyme Neuroborreliosis 318 99.72 Very High Very High Very High
Neuroblastoma 123 99.70 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 75 99.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To address the molecular mechanisms of dementia and delirium associated with anesthesia and surgery, we assessed whether the Abeta fibrillar aggregation inhibitor Congo red can attenuate isoflurane-induced caspase-3 activation in H4 human neuroglioma cells overexpressing human beta-amyloid precursor protein (APP).
Gene_expression (overexpressing) of APP associated with anesthesia, dementia, alzheimer's dementia, delirium, isoflurane and abeta
1) Confidence 0.78 Published 2006 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Abstract Doc Link 17234824 Disease Relevance 0.84 Pain Relevance 0.36
RESULTS: We found that isoflurane induces cellular apoptosis in a dose-dependent manner, and that Congo red inhibits isoflurane-induced apoptosis in H4 human neuroglioma cells overexpressing APP.
Gene_expression (overexpressing) of APP
2) Confidence 0.78 Published 2006 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Body Doc Link 17234824 Disease Relevance 0.08 Pain Relevance 0
may be indicators of altered APP expression and/or metabolism.
Gene_expression (expression) of APP
3) Confidence 0.77 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 0.68 Pain Relevance 0
Overexpression of APP, overproduction of A?
Gene_expression (Overexpression) of APP
4) Confidence 0.77 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC1824787 Disease Relevance 0.48 Pain Relevance 0
For evaluation of OSBP1, APP, and APP-CTFs expression levels in HEK-APPNFEV, cell monolayers were washed twice with ice-cold PBS and lysed in PBS containing 1% Triton X-100, 1 mM PMSF and Complete protease inhibitor cocktail (Roche, Indianapolis, IN) for 30 min on ice.
Gene_expression (expression) of APP-CTFs
5) Confidence 0.76 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.06 Pain Relevance 0
Co-expressing OSBP1 with an APP-GFP construct indicated that OSBP1 did not affect the gross intracellular distribution of APP, in the presence or absence of OSBP1 ligand 25OH (Figure 4A).
Gene_expression (expressing) of APP-GFP
6) Confidence 0.76 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
We found that overexpression of OSBP1 in cells stably expressing APP led to downregulation of the amyloidogenic processing shown by a decrease in APP-CTF?
Gene_expression (expressing) of APP
7) Confidence 0.76 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.13 Pain Relevance 0
in the brains of each group to determine whether any change in the amount or solubility of peptide occurred while APPswe/ind expression was suppressed.
Gene_expression (expression) of APP in brains
8) Confidence 0.75 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.08 Pain Relevance 0
In contrast to gamma-secretase inhibitors, Abeta42-lowering NSAIDs do not impair S3 cleavage in the NOTCH receptor and release of the NOTCH intracellular domain, a finding with conceptual implications for the development of safer drugs targeting Abeta production through gamma-secretase modulation.
Gene_expression (production) of Abeta in cleavage associated with cinod and abeta
9) Confidence 0.75 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12777371 Disease Relevance 0.31 Pain Relevance 0.54
New lines of transgenic mice were developed for this study that express high levels of APPswe/ind under the control of a tetracycline-responsive promoter.
Gene_expression (express) of APP associated with targeted disruption
10) Confidence 0.75 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.83 Pain Relevance 0.03
HEK cells stably expressing APP695 bearing the K595N/M596L AD-causing mutation [36] and CHO cells stably transfected with APP751 with the V717F AD-causing mutation [37] were maintained in medium containing 200 ?
Gene_expression (expressing) of APP in CHO associated with alzheimer's dementia
11) Confidence 0.75 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0.31 Pain Relevance 0
APP was constitutively expressed, with diffuse staining of neurons and blood vessels being detected in all cats.
Gene_expression (expressed) of APP in neurons
12) Confidence 0.74 Published 2006 Journal J. Feline Med. Surg. Section Abstract Doc Link 16603401 Disease Relevance 0.61 Pain Relevance 0.26
Immunohistochemical methods were used to detect Abeta and its intracellular precursor protein (amyloid precursor protein (APP)) and hyperphosphorylated-tau.
Gene_expression (detect) of amyloid precursor protein associated with alzheimer's dementia and abeta
13) Confidence 0.74 Published 2006 Journal J. Feline Med. Surg. Section Abstract Doc Link 16603401 Disease Relevance 0.63 Pain Relevance 0.26
Immunohistochemical methods were used to detect Abeta and its intracellular precursor protein (amyloid precursor protein (APP)) and hyperphosphorylated-tau.
Gene_expression (detect) of APP associated with alzheimer's dementia and abeta
14) Confidence 0.74 Published 2006 Journal J. Feline Med. Surg. Section Abstract Doc Link 16603401 Disease Relevance 0.63 Pain Relevance 0.26
It has been reported that H2O2 can induce APP expression and thereby enhance A?
Gene_expression (expression) of APP
15) Confidence 0.74 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.89 Pain Relevance 0.04
In contrast to previous reports (16-18, 20), immunoblot analysis and fluorogenic substrate assay showed that APP expression or ?
Gene_expression (expression) of APP
16) Confidence 0.74 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.27 Pain Relevance 0
In the previous reports, changes in APP expression or ?
Gene_expression (expression) of APP
17) Confidence 0.74 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.24 Pain Relevance 0
All that, in addition to the quick progresses obtained in genetics, in the neuronal transplants, in the administration of neurotrophical factors, in monogangliosides, in the intervention on the production of the beta-amyloid protein or in the excitatory amino acid toxicity prevention make it possible to conceive realistic hopes on the discovery of a future effective therapy for the AD.
Gene_expression (production) of beta-amyloid protein in neuronal associated with toxicity, alzheimer's dementia, disease and excitatory amino acid
18) Confidence 0.74 Published 1995 Journal Rev Neurol Section Abstract Doc Link 8548650 Disease Relevance 0.90 Pain Relevance 0.14
The mouse model of AD over-expressing the Amyloid Precursor Protein (APP) gene shows amyloid plaques similar to the ones found in the brains of AD patients.
Gene_expression (expressing) of APP in brains associated with alzheimer's dementia, disease and amyloid plaque
19) Confidence 0.72 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866463 Disease Relevance 1.41 Pain Relevance 0.06
The mouse model of AD over-expressing the Amyloid Precursor Protein (APP) gene shows amyloid plaques similar to the ones found in the brains of AD patients.
Gene_expression (expressing) of Amyloid Precursor Protein in brains associated with alzheimer's dementia, disease and amyloid plaque
20) Confidence 0.72 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866463 Disease Relevance 1.40 Pain Relevance 0.06

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