INT44971

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Context Info
Confidence 0.60
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.08
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dhrs4) oxidoreductase activity (Dhrs4) peroxisome (Dhrs4)
Anatomy Link Frequency
fat 1
liver lobule 1
Dhrs4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methadone 6 99.44 Very High Very High Very High
Bile 64 94.12 High High
Inflammation 9 63.56 Quite High
Dopamine 26 5.00 Very Low Very Low Very Low
agonist 24 5.00 Very Low Very Low Very Low
dopamine receptor 20 5.00 Very Low Very Low Very Low
antagonist 11 5.00 Very Low Very Low Very Low
long-term potentiation 6 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
midbrain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 17 83.28 Quite High
Diabetes Mellitus 10 78.32 Quite High
Obesity 32 77.52 Quite High
Metabolic Disorder 9 71.92 Quite High
Impaired Glucose Tolerance 8 68.72 Quite High
INFLAMMATION 9 63.56 Quite High
Endotoxemia 3 59.96 Quite High
Shock 10 57.28 Quite High
Body Weight 13 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NADPH dehydrogenase was increased in the central areas of the liver lobule within 3 days of ME treatment.
Positive_regulation (increased) of NADPH dehydrogenase in liver lobule associated with methadone
1) Confidence 0.60 Published 1984 Journal Arch. Toxicol. Suppl. Section Abstract Doc Link 6595989 Disease Relevance 0 Pain Relevance 0.54
This is due to both increases in the numbers of CR+ and decreases in the numbers of CR?
Positive_regulation (increases) of CR
2) Confidence 0.01 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567422 Disease Relevance 0.06 Pain Relevance 0
Feeding the high fat diet increased the urinary excretion of PSP and Cr-EDTA, indicators of intestinal permeability, in both LETO and OLETF rats at 3, 9, and 15 weeks after the onset of feeding.
Positive_regulation (increased) of Cr-EDTA in fat
3) Confidence 0.00 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 1.02 Pain Relevance 0.08

General Comments

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