INT44998

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Context Info
Confidence 0.42
First Reported 1983
Last Reported 2009
Negated 1
Speculated 2
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.37
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eef1a2) GTPase activity (Eef1a2) cytoplasm (Eef1a2)
Anatomy Link Frequency
Artery 1
posterior 1
synapses 1
Eef1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 68 100.00 Very High Very High Very High
primary somatosensory cortex 56 100.00 Very High Very High Very High
Serotonin 6 100.00 Very High Very High Very High
antagonist 14 99.60 Very High Very High Very High
5HT 16 99.00 Very High Very High Very High
ischemia 1 98.68 Very High Very High Very High
fluoxetine 6 94.40 High High
Angina 6 94.24 High High
cerebral cortex 6 91.12 High High
Deafferentation 1 86.64 High High
Disease Link Frequency Relevance Heat
Calcification 139 99.96 Very High Very High Very High
Coronary Artery Disease 8 99.12 Very High Very High Very High
Atherosclerosis 12 98.66 Very High Very High Very High
Adhesions 1 98.32 Very High Very High Very High
Cv General 3 Under Development 5 94.24 High High
Myocardial Infarction 6 92.88 High High
Death 2 91.00 High High
Acute Coronary Syndrome 2 83.88 Quite High
Stable Angina Pectoris 1 73.28 Quite High
Depression 46 62.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, statin therapy did not affect the RR in patients with Q-wave AMI during 6-month follow-up (RR 7.9, 95% CI 1.6 to 39 vs RR 7.6, 95% CI 1.5 to 37, p = NS).
Neg (not) Regulation (affect) of statin
1) Confidence 0.42 Published 2002 Journal Am. J. Cardiol. Section Abstract Doc Link 11779513 Disease Relevance 0.52 Pain Relevance 0.22
Additionally, 4 randomized controlled trials have examined the use of statin therapy for ACS: the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) study, the Pravastatin Turkish Trial, the Fluvastatin on Risk Diminishing After Acute Myocardial Infarction (FLORIDA) study, and the Lipid-Coronary Artery Disease (L-CAD) study.
Spec (examined) Regulation (use) of statin in Artery associated with coronary artery disease, ischemia and myocardial infarction
2) Confidence 0.36 Published 2002 Journal Mayo Clin. Proc. Section Abstract Doc Link 12374252 Disease Relevance 0.70 Pain Relevance 0.12
Manipulations of synaptic serotonin: discrepancy of effects on serotonin S1 and S2 sites.
Regulation (effects) of S1 associated with serotonin
3) Confidence 0.12 Published 1983 Journal Life Sci. Section Title Doc Link 6602261 Disease Relevance 0 Pain Relevance 0.80
The data show that manipulation of synaptic 5HT concentration does not always result in parallel changes in S1 and S2 receptors.
Regulation (changes) of S1 associated with 5ht
4) Confidence 0.06 Published 1983 Journal Life Sci. Section Abstract Doc Link 6602261 Disease Relevance 0 Pain Relevance 0.75
Additionally, the results also suggest that there are multiple forms and loci (i.e., excitatory and inhibitory synapses) of synaptic plasticity that affect the expression of plasticity in a complex circuit, such as supragranular S1.
Regulation (affect) of S1 in synapses associated with primary somatosensory cortex
5) Confidence 0.04 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2832108 Disease Relevance 0.06 Pain Relevance 0.19
Since calcium is such a major component of advanced atherosclerotic lesions, we furthermore studied whether the CA amlodipine and the statin atorvastatin, alone and in combination, affected calcification of aortic VSMCs in vitro.


Spec (whether) Regulation (affected) of statin associated with calcification, atherosclerosis and antagonist
6) Confidence 0.02 Published 2007 Journal Mol Cell Biochem Section Body Doc Link PMC2226060 Disease Relevance 0.90 Pain Relevance 0.16
Arrays targeting HP, S1, and V1 (Figure 1C) were centered on the following stereotaxic coordinates on the left hemisphere, in mm from Bregma with respect to the antero-posterior (AP), medio-lateral (ML), and dorso-ventral (DV) axes (Paxinos and Watson, 1997): HP (AP: ?
Regulation (targeting) of S1 in posterior associated with primary somatosensory cortex and hippocampus
7) Confidence 0.02 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0 Pain Relevance 0.31
Effect of preexisting statin use on expression of C-reactive protein, adhesion molecules, interleukin-6, and antioxidized low-density lipoprotein antibody in patients with unstable angina undergoing coronary stenting.
Regulation (Effect) of statin associated with angina and adhesions
8) Confidence 0.00 Published 2005 Journal Clin Cardiol Section Title Doc Link 15757077 Disease Relevance 0.19 Pain Relevance 0.09

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