INT45014

Context Info Confidence 0.14 First Reported 1983 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 12 Total Number 13 Disease Relevance 1.87 Pain Relevance 2.67

signal transduction (IL1RL1) extracellular space (IL1RL1) extracellular region (IL1RL1) plasma membrane (IL1RL1) intracellular (IL1RL1)

Anatomy Link Frequency grid 2 forearm 1 bone marrow 1 midbrain tegmentum 1 IL1RL1 (Homo sapiens)

Pain Link Frequency Relevance Heat deep brain stimulation 10 100.00 midbrain 3 99.28 Perioperative pain 5 97.16 Cluster headache 5 93.04 positron emission tomography 4 92.24 Paracetamol 4 91.08 Spinal cord 1 90.52 headache 7 90.32 depression 30 88.28 Pain 9 85.96

Disease Link Frequency Relevance Heat Convulsion 6 98.28 Post Operative Pain 5 97.16 Cluster Headache 5 93.04 Trigeminal Autonomic Cephalalgias 4 90.32 Depression 30 88.28 Pain 7 85.96 Cognitive Disorder 11 65.52 Myopia 1 64.56 Anxiety Disorder 3 52.96 Obesity 48 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The plot of T4/T1 as a function of T1 for the same two subjects reveals that, for any given value of T1, the T4/T1 ratio is higher during the onset than during the offset of NMB (lower panel in Figure 1).

Regulation (value) of T1

1) Confidence 0.14 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.17 Pain Relevance 0.09

T4/T1-T1 data pairs observed during the onset of NMB produced by different doses of vecuronium, as well as the mean values of T4/T1-T1 observed in all patients during the offset of NMB (Figure 2), were superimposed on the grid relating T4/T1 ratios to T1 at different levels of [A]4/[A]1 (lower panel in Figure 3).

Regulation (values) of T1 in grid

2) Confidence 0.14 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0 Pain Relevance 0

T4/T1-T1 data pairs observed during the onset of NMB produced by different doses of vecuronium, as well as the mean values of T4/T1-T1 observed in all patients during the offset of NMB (Figure 2), were superimposed on the grid relating T4/T1 ratios to T1 at different levels of [A]4/[A]1 (lower panel in Figure 3).

Regulation (values) of T1 in grid

3) Confidence 0.14 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0 Pain Relevance 0

The influence of electrode size on selectivity and comfort in transcutaneous electrical stimulation of the forearm.

Regulation (influence) of stimulation in forearm

4) Confidence 0.10 Published 2010 Journal IEEE Trans Neural Syst Rehabil Eng Section Title Doc Link 20071267 Disease Relevance 0.17 Pain Relevance 0.22

The measured T1 and T2 values at this field are summarized in Table 2.

Regulation (values) of T1

5) Confidence 0.09 Published 2008 Journal Journal of Lipid Research Section Body Doc Link PMC2515528 Disease Relevance 0 Pain Relevance 0.04

Calf subcutaneous fat has shorter T1 and T2 values, about 7% on average, in comparison with tibial bone marrow.

Regulation (values) of T1 in bone marrow

6) Confidence 0.09 Published 2008 Journal Journal of Lipid Research Section Body Doc Link PMC2515528 Disease Relevance 0 Pain Relevance 0.03

It should be pointed out that because of the presence of proton J-coupling, these T1 and T2 values are valid only for STEAM sequence.

Regulation (values) of T1

7) Confidence 0.09 Published 2008 Journal Journal of Lipid Research Section Body Doc Link PMC2515528 Disease Relevance 0 Pain Relevance 0.03

The results generally showed that c can considerably affect DT, t1, t50 and t90 of the tablets.

Regulation (affect) of t1

8) Confidence 0.03 Published 2007 Journal Acta Pharm Section Abstract Doc Link 19839408 Disease Relevance 0 Pain Relevance 0.15

There must be a transition from the subSTZ waveform to the supraSTZ waveform at the start of a prolonged stimulation at a (nearly) uniform repetition-rate.

Regulation (prolonged) of stimulation

9) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1483834 Disease Relevance 0 Pain Relevance 0

In general, the most common ranking of the individual effects on DT, t1, t50 and t90 for native/native, pregelatinized/pregelatinized and native/pregelatinized starch binder formulations was c > d > N.

Regulation (effects) of t1

10) Confidence 0.02 Published 2007 Journal Acta Pharm Section Abstract Doc Link 19839408 Disease Relevance 0 Pain Relevance 0.17

The precise anatomical localization of the deep brain stimulation (DBS) target places it at the midbrain tegmentum rather than the posterior hypothalamus.

Regulation (target) of stimulation in midbrain tegmentum associated with deep brain stimulation and midbrain

11) Confidence 0.01 Published 2010 Journal Curr Pain Headache Rep Section Abstract Doc Link 20425205 Disease Relevance 0.74 Pain Relevance 1.31

The important information that needs to be carefully discussed in future reports of EBS include: information about the exact location of the stimulation, the physiological condition of the stimulated area, mode of stimulation, i.e., unipolar versus bipolar current, after-discharges or electrographic seizures during stimulation, and the variability of the perceptual or behavioral phenomena by altering the stimulation parameters.

Regulation (altering) of stimulation associated with convulsion

12) Confidence 0.01 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2889679 Disease Relevance 0.29 Pain Relevance 0.08

The influence of transcutaneous electrical stimulation (TES) and psychological factors in determining the intensity of acute postoperative pain was examined in a prospective, double-blind controlled trial completed by 30 patients having elective surgery.

Spec (examined) Regulation (influence) of stimulation associated with perioperative pain

13) Confidence 0.00 Published 1983 Journal Pain Section Abstract Doc Link 6606153 Disease Relevance 0.50 Pain Relevance 0.56

General Comments

This test has worked.