INT45035

Context Info Confidence 0.16 First Reported 1983 Last Reported 1984 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.74 Pain Relevance 0.44

plasma membrane (HLA-B, HLA-DRB4) endosome (HLA-DRB4) signal transduction (HLA-DRB4) Golgi apparatus (HLA-DRB4) endoplasmic reticulum (HLA-DRB4)

HLA-B (Homo sapiens) HLA-DRB4 (Homo sapiens)

Pain Link Frequency Relevance Heat spinal inflammation 2 100.00 rheumatoid arthritis 1 99.80 Crohn's disease 5 99.26

Disease Link Frequency Relevance Heat Low Back Pain 1 100.00 Rheumatoid Arthritis 2 99.80 Disease 8 99.26 Ankylosing Spondylitis 1 5.00 Celiac Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the patients with Crohn's disease there was a strong association with HLA-DR4 and -DR5 (chi2 = 14 . 013, RR = 4 . 77 and chi2 = 9 . 345, RR = 5 . 04) and a weak association with HLA-Bw46 and -Bw51 (chi2 = 7 . 077, RR = 2 . 63, and chi2 = 5 . 401, RR = 2 . 52).

HLA-Bw46 Binding (association) of HLA-DR4 associated with crohn's disease and disease

1) Confidence 0.16 Published 1984 Journal J Clin Lab Immunol Section Abstract Doc Link 6611420 Disease Relevance 0.44 Pain Relevance 0.29

Measures of association for HLA-B27 and ankylosing spondylitis (AS) and HLA-DR4 and rheumatoid arthritis (RA) are calculated from previously published data.

HLA-B27 Binding (association) of HLA-DR4 associated with spinal inflammation and rheumatoid arthritis

2) Confidence 0.04 Published 1983 Journal J Rheumatol Suppl Section Abstract Doc Link 6607352 Disease Relevance 0.30 Pain Relevance 0.15

General Comments

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