INT45064

Context Info Confidence 0.86 First Reported 1983 Last Reported 2003 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 0 Pain Relevance 1.80

signal transduction (TRIM13) endoplasmic reticulum (TRIM13) intracellular (TRIM13) ligase activity (TRIM13) cytoplasm (TRIM13) signal transducer activity (TRIM13)

Anatomy Link Frequency Caco-2 2 plasma 1 TRIM13 (Homo sapiens)

Pain Link Frequency Relevance Heat Somatostatin 4 100.00 Enkephalin 16 99.96 opioid receptor 2 97.68 Neuropeptide 6 90.12 Delta opioid receptors 2 88.88 Potency 2 85.76 agonist 1 58.64 analgesia 1 55.68 tail-flick 1 54.80 Opioid 6 50.00

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The kinetics of degradation of the synthetic peptoids digestion by rat and human plasma enzymes were compared with that of [Leu5]-enkephalin.

Protein_catabolism (degradation) of Leu5 in plasma associated with enkephalin

1) Confidence 0.86 Published 2003 Journal J. Pept. Sci. Section Abstract Doc Link 14620129 Disease Relevance 0 Pain Relevance 0.41

The synthesis, bioactivity and enzyme stability of D-Ala2, EPhe4, Leu5-enkephalins.

Protein_catabolism (stability) of Leu5 associated with enkephalin

2) Confidence 0.64 Published 1983 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 6615520 Disease Relevance 0 Pain Relevance 0.29

Phosphoramidon and DL-thiorphan similarly inhibited the degradation of GRP-10 (mean of 35% inhibition), somatostatin-14 (57%) and the aminopeptidase-resistant analogue, [D-Ala2][Leu5]enkephalin (75%).

Protein_catabolism (degradation) of Leu5 associated with somatostatin and enkephalin

3) Confidence 0.63 Published 1993 Journal Exp. Physiol. Section Abstract Doc Link 8448012 Disease Relevance 0 Pain Relevance 1.10

Prodrug 1 was 1680 fold more able to permeate the Caco-2 cell monolayers than was [Leu5]-enkephalin, in part because of its increased enzymatic stability.

Protein_catabolism (stability) of Leu5 in Caco-2

4) Confidence 0.43 Published 1999 Journal Pharm. Res. Section Body Doc Link 9950273 Disease Relevance 0 Pain Relevance 0

Prodrug 1 was 665-fold more able to permeate the Caco-2 cell monolayers than was [Leu5]-enkephalin, in part because of its increased enzymatic stability.

Protein_catabolism (stability) of Leu5 in Caco-2

5) Confidence 0.40 Published 1999 Journal Pharm. Res. Section Body Doc Link 9950272 Disease Relevance 0 Pain Relevance 0

RESULTS: Cyclic prodrugs 1 and 2 degraded slowly but stoichiometrically to [Leu5]-enkephalin and DADLE, respectively, in HBSS, pH = 7.4.

Protein_catabolism (degraded) of Leu5

6) Confidence 0.33 Published 1999 Journal Pharm. Res. Section Body Doc Link 9950274 Disease Relevance 0 Pain Relevance 0

General Comments

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