INT45142

Context Info Confidence 0.56 First Reported 1983 Last Reported 2011 Negated 2 Speculated 3 Reported most in Body Documents 109 Total Number 116 Disease Relevance 84.71 Pain Relevance 16.87

cytosol (DCPS) mitochondrion (DCPS) nucleolus (DCPS) nucleus (DCPS) cytoplasm (DCPS)

Anatomy Link Frequency blood 10 T cells 10 monocyte 7 DCs 6 plasma 4 DCPS (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 796 100.00 chemokine 311 100.00 rheumatoid arthritis 1150 99.84 Multiple sclerosis 130 99.66 Pain 68 99.60 carpal tunnel syndrome 69 99.38 nMDA receptor 1 99.36 headache 32 98.80 Migraine 1 98.72 Inflammation 926 98.52

Disease Link Frequency Relevance Heat Systemic Lupus Erythematosus 1579 100.00 Adenocarcinoma 1476 100.00 Syndrome 38 100.00 Virus Diseases 14 100.00 Rheumatoid Arthritis 1150 99.84 Prostate Cancer 322 99.80 Demyelinating Disease 136 99.66 Cancer 2547 99.64 Pain 63 99.60 Hookworm Infection 140 99.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results showed that ratings of unpleasantness and discomfort/pain were significantly decreased during DLPFC tDCS only, as compared to baseline and sham tDCS.

Gene_expression (decreased) of tDCS associated with pain

1) Confidence 0.56 Published 2009 Journal Neuropsychologia Section Abstract Doc Link 18725237 Disease Relevance 0.83 Pain Relevance 0.89

The DCPS projection may play a role in the modulation of touch and pain perception.

Gene_expression (projection) of DCPS associated with pain

2) Confidence 0.43 Published 1983 Journal Exp. Neurol. Section Abstract Doc Link 6628631 Disease Relevance 0.16 Pain Relevance 0.31

The effectiveness of tDCS is currently being explored in migraine research as well as experimentally induced and chronic pain conditions.

Gene_expression (effectiveness) of tDCS associated with lasting pain and migraine

3) Confidence 0.36 Published 2010 Journal Schmerz Section Abstract Doc Link 20376605 Disease Relevance 0.60 Pain Relevance 0.71

TRPV1 expression was identified both at the protein and gene levels in human DCs.

Gene_expression (expression) of DCs in DCs

4) Confidence 0.20 Published 2009 Journal FEBS Lett. Section Abstract Doc Link 19397909 Disease Relevance 0.08 Pain Relevance 0.31

The goal of the current study was to investigate the expression of transient receptor potential vanilloid-1 (TRPV1) on human in vitro differentiated monocyte-derived dendritic cells (DCs) and to dissect the corresponding role of TRPV1-signaling in DC-specific functions.

Spec (investigate) Gene_expression (expression) of DCs in monocyte

5) Confidence 0.18 Published 2009 Journal FEBS Lett. Section Abstract Doc Link 19397909 Disease Relevance 0.07 Pain Relevance 0.26

The PSA RNA-transfected DCs were administered at three escalating dose levels.

Gene_expression (transfected) of DCs

6) Confidence 0.15 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 0.65 Pain Relevance 0.05

Mature DCs express high levels of Class I and Class II molecules, altered chemokine and galectin family (Dietz et al 2000; Bax et al 2007) expression, co-stimulatory markers CD80 and CD86, and the immunoglobulin CD83 (Zhou and Tedder 1995).

Gene_expression (express) of DCs in CD86 associated with chemokine

7) Confidence 0.14 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727883 Disease Relevance 0.37 Pain Relevance 0.10

Furthermore, CXCL8 is a chemoattractant that will attract many different cell types expressing CXCR1 or CXCR2 including DCs [45] and the presence of CXCL8 in blood may affect their ability to exit the blood stream and affect their viability.

Gene_expression (expressing) of DCs in blood

8) Confidence 0.14 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 1.48 Pain Relevance 0.21

DCs were generated from monocytes in the presence of GM-CSF and IL-4 and subsequently transfected with PSA RNA.

Gene_expression (transfected) of DCs in monocytes

9) Confidence 0.13 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 0.80 Pain Relevance 0.06

Thus, the potential of RNA-transfected DCs for PCa therapy was investigated.

Gene_expression (transfected) of DCs associated with prostate cancer

10) Confidence 0.13 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 0.80 Pain Relevance 0.06

Mu et al. conducted a clinical study enrolling 20 HRPC patients, which was based on the administration of monocyte-derived DCs transfected with RNA from allogeneic PCa cell lines [79].

Gene_expression (transfected) of DCs in monocyte associated with prostate cancer

11) Confidence 0.13 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 0.60 Pain Relevance 0

Each patient received at least four weekly injections with 2 × 107 transfected DCs either intranodally or intradermally.

Gene_expression (transfected) of DCs

12) Confidence 0.13 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 0.49 Pain Relevance 0

Another clinical trial was performed to evaluate the efficiency of mature monocyte-derived DCs pulsed with human recombinant PSA protein for the treatment of PCa patients in biochemical relapse after radical prostatectomy [70].

Gene_expression (pulsed) of DCs in monocyte associated with prostate cancer and recurrence

13) Confidence 0.13 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 0.70 Pain Relevance 0

In this context, Heiser et al. vaccinated PSA RNA-transfected DCs to 13 metastatic PCa patients [77].

Gene_expression (transfected) of DCs associated with prostate cancer

14) Confidence 0.13 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 0.77 Pain Relevance 0.06

Apart from higher expression of HLA-DR, the numbers and phenotypes of SF pDCs were similar to those of normal PB pDCs.

Gene_expression (expression) of pDCs

15) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065313 Disease Relevance 0.97 Pain Relevance 0.40

In response to viruses and CpG DNA, pDCs become activated to produce IFN-?

Gene_expression (produce) of pDCs

16) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.67 Pain Relevance 0.19

Of note, we did not see any correlation between tumor differentiation grade or stage and the levels of blood DCs (data not shown).

Gene_expression (levels) of DCs in blood associated with cancer

17) Confidence 0.12 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 1.84 Pain Relevance 0.10

Dysfunctional DCs exist in many cancers including PDAC, where impairment of T cell stimulatory function among the MDCs has been detected [15].

Gene_expression (exist) of DCs in T cell associated with adenocarcinoma and cancer

18) Confidence 0.12 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 2.27 Pain Relevance 0.21

Taken together, our findings indicate that CXCL8 is not directly involved in the depletion of blood DCs in PDAC or other pancreatic tumor patients but do not exclude that the recovery of DCs may take longer time than the normalization of inflammatory factors, such as CXCL8, in blood.

Gene_expression (recovery) of DCs in blood associated with adenocarcinoma, inflammation and pancreatic cancer

19) Confidence 0.12 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 1.79 Pain Relevance 0.17

Taken together, our findings indicate that CXCL8 is not directly involved in the depletion of blood DCs in PDAC or other pancreatic tumor patients but do not exclude that the recovery of DCs may take longer time than the normalization of inflammatory factors, such as CXCL8, in blood.

Gene_expression (depletion) of DCs in blood associated with adenocarcinoma, inflammation and pancreatic cancer

20) Confidence 0.12 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 1.81 Pain Relevance 0.17

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